1,720,986 research outputs found
Synthesis and 3D-Structural Analysis of Peptides Based on AntAib, an Anthracene-Fused 1-Aminocyclopentanecarboxylic Acid.
No full textK. Rolka, P. Rekowski, and J. Silberring Eds., Kenes Int., Geneva, Switzerland, 2007, pp. 88-89
Designed 3-14-Helical β-Peptides Based on Crowned (S)-β3-H-DOPA Combined with (1S, 2S)-ACHC Residues.
No full textK. Rolka, P. Rekowski, and J. Silberring Eds., Kenes Int., Geneva, Switzerland, 2007, pp. 86-87
Induced Axial Chirality in the Biphenyl Core of 6,7-Dihydro-5H-Dibenz[c, e] Azepine Derivatives of α- and β-Amino Esters
No full textK. Rolka, P. Rekowski, and J. Silberring Eds., Kenes Int., Geneva, Switzerland, 2007, pp. 82-83
Exciton Couplet Circular Dichroism of Intramolecularly Interacting bis-Porphyrin Chromophores in Peptide Conjugates: Distance and Orientation Effects.
No full textK. Rolka, P. Rekowski, and J. Silberring Eds., Kenes Int., Geneva, Switzerland, 2007, pp. 40-41
Biophysical properties of alamethicin F50/5 and selected analogues inserted in rod outer segment membranes
No full textThe biophysical characteristics and the pore formation dynamics of synthetic, naturally occurring peptides forming membrane-spanning channels were investigated by using isolated rod outer segments (OS) of reptilia and amphibia recorded in whole-cell configuration. The peptides were applied (and removed) to the OS in 5 GΏ. Therefore, any exogenous current can be studied down to the single channel level. Macroscopic currents of amplitude of ~300 pA were recorded in symmetric K+ or Na+ (>100 mM) and Ca2+ (1 mM) from the synthetic, naturally occurring alamethicin F50/5 and selected analogs applied at 1 μM concentration at –20 mV. Once applying and removing the peptide, the current activated and deactivated with a time constant of about 160 ms. The synthetic analogs Glu(OMe)7,18,19 and Glu(OMe)18,19 of the F50/5 produced a current of about 100 pA at 1 μM concentration, and they showed a strong activation by hyperpolarization as alamethicin F50/5. Clear single channel events were observed when the concentration of all the above peptides was reduced to <250 nM. However, no current was recorded from the synthetic nOtt-(11)-OMe trichogin at 1 μM for voltages up to +/- 60 mV. These results indicate that the Gln residues at positions 7, 18 and 19 of alamethicin are not a key factor for pore formation and its conduction properties. In general, the pore assembly and disassembly are very fast and cooperative events
Engineering Bioinspired Luminescent Probes: Antimicrobial Peptides Chelating Lanthanide Ions.
No full textK. Rolka, P. Rekowski, and J. Silberring Eds., Kenes Int., Geneva, Switzerland, 2007, pp. 96-97
The "BIP METHOD" for assignment of the absolute configuration of the beta-amino acids: ICD in the biphemyl core of Bip-beta-XAA* dipeptides
No full textThe possible role of Gly residues in prion octarepeat region in coordination of Cu2+ ions
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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