35 research outputs found
The development of affective behavioral complexes: a level-based model
No full textThe author discusses sources for, problems in, and ways of forming a hierarchical model of the development of whole affective behavioral complexes, not just mechanisms of emotional regulation, as was done in the original level-based model elaborated by Victor Lebedinsky. The author describes specific traits of affective behavioral complexes and types of links between them on different levels. Primitive affective behavioral complexes, either isolated or rigidly linked, dominate on the lower three levels. On the fourth level attachment behavior plays a “star” role, mediating and regulating all vital behaviors. On the fifth level symbolic activity permanently rebuilds the experience obtained on the lower levels. The author discusses links between affective behavioral complexes and nuclear personality formations
Биоразлагаемый смазочный материал для железнодорожного транспорта
No full textBoron-containing lubricant for rail-curve lubrication is developed. Its effectiveness was proved by series of experiments carried out on different types of friction machines. The mechanism of antiscoring effect of boron-containing additives was analyzed in terms of physical adsorption.Разработан смазочный материал для контакта колесо-рельс, содержащий борную присадку. Его эффективность была подтверждена серией опытов на различных типах машин трения. Механизм противозадирного действия борной присадки был проанализирован с позиции физической адсорбции
Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m2 24 h or 1.3 mg/m2 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer
No full textThis randomized, open-label, phase II clinical trial evaluated the optimal regimen of trabectedin administered every 3 weeks in patients with platinum-sensitive, relapsed, advanced ovarian cancer (AOC). Patients previously treated with less than two or two previous chemotherapy lines were randomized to receive trabectedin 1.5 mg/m(2) 24 h (arm A, n = 54) or 1.3 mg/m(2) 3 h (arm B, n = 53). Objective response rate (ORR) per RECIST was the primary efficacy end point. Toxic effects were graded according to the National Cancer Institute-Common Toxicity Criteria v. 2.0. ORR was 38.9% [95% confidence interval (CI) 25.9% to 53.1%; arm A] and 35.8% (95% CI 23.1% to 50.2%; arm B) (intention-to-treat primary analysis). Median time to progression was 6.2 months (95% CI 5.3-8.6 months; arm A) and 6.8 months (95% CI 4.6-7.4 months; arm B). Frequent severe adverse events were nausea/vomiting (24%, arm A; 15%, arm B) and fatigue (15%, arm A; 10%, arm B). Common severe laboratory abnormalities were transient, noncumulative neutropenia (55%, arm A; 37%, arm B) and transaminase increases (alanine aminotransferase, 55%, arm A; 59%, arm B). Both every-3-weeks trabectedin regimes, 1.5 mg/m(2) 24 h and 1.3 mg/m(2) 3 h, were active and reasonably well tolerated in AOC platinum-sensitive patients. Trabectedin every-3-weeks has promising activity and deserves to be further evaluated in relapsed AO
Analysis of precipitation kinetics of manganese and copper sulfides in interstitial free steels
No full textModel of precipitation is based on classical theory of nucleation and growth with description of numeric methods for modeling. Now authors present numerical calculations of precipitation kinetics. In the beginning they repeat basic formulas of this model
Modeling of precipitation kinetics of manganese and copper sulfides in interstitial free steels
No full text
Analysis of precipitation kinetics of manganese and copper sulfides in interstitial free steels
No full textModel of precipitation is based on classical theory of nucleation and growth with description of numeric methods for modeling. Now authors present numerical calculations of precipitation kinetics. In the beginning they repeat basic formulas of this model
Modeling of precipitation kinetics of manganese and copper sulfides in interstitial free steels
No full textModel of precipitation kinetics of copper and manganese sulfides in ultra low-carbon and interstitial free steels was created on the basis of classical nucleation and growth theory. The model includes homogeneous and heterogeneous schemes for independent nucleation of manganese and copper sulfides and simultaneous growth/shrinkage of inclusions
