23,376 research outputs found
Person-centred advocacy: Some ethical issues
No full textIn the second of two articles on advocacy for people with dementia Mike Fox with Lesley Wilson considers some of the ethical issues arising from advocacy work within a residential home that was due to close
Preparation of Fox Valley Technical College faculty for multicultural education
No full textIncludes bibliographical references.The purpose of this study was to determine the level of preparedness of Fox Valley Technical College faculty for multicultural education. The demographics of the district population were changing rapidly, and faculty must be prepared to meet the needs of multicultural students. A survey was administered to full- and part-time faculty of Fox Valley Technical College. The survey was intended to collect data about levels of education and experience, perceived training needs, level of comfort with multicultural education and level of interest in further training. The data gathered was analyzed to determine the need for future training, training subjects, and the training formats preferred by faculty. The results of this research provide a basis on which to build future professional growth training at Fox Valley Technical College. The training for faculty will ensure higher success for both faculty and students
THEORY OF ANOMALOUS LINE STREGTHS IN ISOTOPICALLY SUBSTITUTED SPHERICAL TOP
No full textResearch supported by the National Aeronautics and Space Administration. K. Fox, D.E. Jennings, G. W. Halsey, and S. J. Daunt, Paper TAS, 34th Symposium on Molecular Spectroscopy, The Ohio State University (1979). K. Fox, G. W. Halsey, S. J. Daunt, W.E. Blass, and D. E. Jennings, J. Chem. Phys., to be published 15 April 1980.Author Institution:Recent measurements of absolute strengths of the singlets Q1, RO, and R1 for and , under identical experimental conditions designed to minimize errors in derived relative strengths, demonstrated that isotopic substitution for the central atom in a spherical top can affect these strengths dramatically. In an effort to explain these apparently anomalous experimental results, vibration-rotation interactions in the multiplets with m + n = 1,2,3,\ldots have been considered. Preliminary theoretical results indicate that the observed isotopic effects, including possible variation with rotational quantum number, can be accounted for satisfactorily
Selective If inhibition:new frontiers inthe management of coronary disease
No full textTHE LAST 30 YEARS HAVE SEEN SPECTACULAR PROGRESS IN THE
management of stable coronary artery disease (CAD), with numerous
new pharmacological and interventional options becoming available.
The most recent statistics from the American Heart Association (AHA)
report a 33% reduction in rates of mortality due to CAD in the 10 years to 2004,1 which can be
largely attributed to these advances. Despite this progress, the disease remains an important
contributor to mortality and morbidity in the Western world. Indeed, the AHA statistics also place
CAD as the single largest killer of American adults, with 1 in 5 deaths being attributable to CAD.1
Clearly, there is little room for complacency in our management of stable CAD, and we need to
continue to seek original and innovative ways of saving lives in this population.
A striking demonstration of this situation came from analysis of data from patients included
in the REduction of Atherothrombosis for Continued Health (REACH) Registry in 44 countries
between 2003 and 2004.2 This 1-year, international study recruited a large subset of more than
38 000 patients with stable CAD. The majority of the REACH patients were receiving contemporary,
evidence-based, preventive drug therapy, including antiplatelet therapy, lipid-lowering agents,
and angiotensin-converting enzyme inhibitors, and about half were receiving β-blockers. Despite
this, all-cause mortality at 1 year was 2.89% and cardiovascular mortality was 1.93%. Patients
with stable CAD also had a 4.52% rate of a composite end point of cardiovascular death, myocardial
infarction (MI), and stroke. The REACH authors rightly concluded that continued efforts are
needed to improve secondary prevention and clinical outcomes.2 The implications of the REACH
data in terms of burden of disease are alarming, considering that the lifetime risk of developing
CAD for American adults aged over 40 is 49% for men and 32% for women.1 One conclusion is
that current management strategies in stable CAD are failing to reach the expectations of cardiologists
and patients alike.3
Current guidelines recommend a two-pronged management strategy for patients with stable
CAD, who require one treatment to relieve symptoms alongside another to reduce long-term morbidity
and mortality.4 Despite the progress in the field, 50% of patients remain symptomatic with
treatment, and rates of mortality are highly unsatisfactory. These shortcomings can be traced to
a number of factors. Pharmacological therapy is abound with problems of subtherapeutic dosing
and compliance. Furthermore, the optimization of treatment can be hindered by insufficient
efficacy in patients with refractory angina and by a long list of contraindications, for example,
β-blockers are contraindicated in patients with asthma, peripheral vascular disease, and severe
bradycardia, which may limit their use in those patient populations. Another factor is poor tolerability,
which may lead to treatment discontinuation and reduce the efficacy of even the most
rigorous management strategy.
Surgical intervention does not necessarily resolve these problems: intervention is not always
possible, and most revascularized patients still require antianginal treatment after the procedure.
Indeed, as the Clinical Outcomes Utilizing Revascularization and AGgressive drug Evaluation
(COURAGE) trial recently demonstrated,5 there is no benefit of percutaneous coronary interven-
E D I T O R I A L
Address for correspondence:
Prof Roberto Ferrari, Chair of
Cardiology, Arcispedale S. Anna,
University of Ferrara, Corso
Giovecca 203, 44100, Ferrara,
Italy and Fondazione Salvatore
Maugeri, IRCCS, Brescia, Italy
(e-mail [email protected])
Prof Kim Fox, Professor of
Cardiology, Royal Brompton
Hospital, London SW3 6NP, UK
(e-mail [email protected])
Medicographia.
2008;30:189-195.
Selective I
f inhibition:
new frontiers in the management
of coronary artery disease
b y R . F e r r a r i a n d K . F o x ,
I t a l y a n d U n i t e d K i n g d o m
Kim FOX, MD, FESC
Professor of Cardiology
Royal Brompton Hospital
London, UK
Roberto FERRARI, MD, PhD
Chair of Cardiology
Arcispedale S. Anna
University of Ferrara
and Fondazione Salvatore
Maugeri, IRCCS
Brescia, ITALY
tion (PCI) on top of guideline-based optimized pharmacological therapy, in terms of reduction
in risk of mortality, MI, or major cardiovascular events. This demonstrates how important it is
to raise our standards in preventive cardiology through improvement of established lifestyle and
therapeutic intervention and control of other clinical parameters, which can improve cardiovascular
risk assessment and management.
The ideal treatment for stable CAD would be one that provided both anti-ischemic and antianginal
efficacy, as well as improvement in prognosis by reducing cardiovascular events. Heart
rate (HR) is one of the clinical parameters that is most frequently assessed in daily practice. Being
the main determinant of ischemia, HR reduction is established as an important therapeutic
component of the prevention of ischemia. A strong association between elevated HR and increased
risk of all-cause mortality, cardiovascular mortality, and development of cardiovascular
disease has been shown in the general population, as well as in patients with hypertension, diabetes,
and CAD.6,7 Experimental data have demonstrated the involvement of HR in the development
of atherosclerosis with reduction in its progression after pharmacological or surgical HR
reduction. The impact of β-blockers and of some calcium blockers on mortality in post-MI patients
has been suggested to be related to reduction in resting HR. Consistent with this understanding
of the important role of HR, ivabradine, the first selective and specific If inhibitor, opens
up promising opportunities in the management of CAD
What Does It Take to Be a Fox? New Horizons for Communities of Practice
No full textIn this theoretical research report we reflect on the challenges of becoming more fox-like in mathematics education work. Using a communities of practice motivating theoretical lens, we compare and discuss the differences in defining, creating, and accessing knowledge between virtual and scholarly communities of practice in mathematics education. We present four claims that virtual communities of practice in mathematics education are inherently foxy work. As part of our claims, we discuss how scholarly communities of practices are inherently hedgehog work. We conclude with a list of recommendations of those within the scholarly communities of practice in mathematics education. These recommendations include looking toward the successful fox-like attributes of the virtual communities in mathematics education
Maintaining Reeb Graphs of Triangulated 2-Manifolds
No full textLet M be a triangulated, orientable 2-manifold of genus g without boundary, and let h be a height function over M that is linear within each triangle. We present a kinetic data structure (KDS) for
maintaining the Reeb graph R of h as the heights of M's vertices vary continuously with time. Assuming the heights of two vertices of M become equal only O(1) times, the KDS processes O((k + g) n \polylog n) events; n is the number of vertices in M, and k is the number of external events which change the combinatorial structure of R. Each event is processed in O(\log^2 n) time, and the total size of our KDS is O(gn). The KDS can be extended to maintain an augmented Reeb graph as well
THEORETICAL STUDIES OF COLLISION-BROADENED LINEWIDTHS IN
No full textAuthor Institution: University of TennesseeOne of the more challenging problems in the theory of vibration-rotation transitions in gas-phase molecules is the prediction or calculation of shapes of spectral lines. An understanding of collision-broadened line shapes, widths and shifts is important in a variety of contexts, including planetary For example, in the atmospheres of Jupiter and Earth, the systems , and , respectively, are of considerable High resolution laboratory spectra have been for the transitions of both and . These data will be analyzed with a view toward developing the theory of collision-broadened line widths of spherical-top molecules, including their isotopic dependence. This research is supported by the Planetary Atmospheres Program of the National Aeronautics and Space Administration, under Grant NAGW-125. See, e.g., J. J. Gelfand, in ``Vibrational-Rotational Spectroscopy for Planetary Atmospheres’’ (M. J. Mumma, K. Fox and J. Hornstein, eds.) NASA 1982. See, e. g., K. Fox in ``Molecular Spectroscopy: Modern Research’’ (K. Narahari Rao and C. W. Mathews), Academic 1972. J. W. Brault, K, Fox, D. E. Jennings, J. S. Margolis, and L. R. Brown, preceding Abstract, this Symposium
Charting the Future for Moral Leadership-- Interiew with Craig Johnson
No full textCraig E. Johnson is director of the Doctor of Business Administration Program and Professor of Leadership Studies at George Fox University in Newberg, Oregon. He is author of several books, including the popular moral leadership textbook, Meeting the Ethical Challenges of Leadership: Casting Light or Shadow, now in its fourth edition, from Sage Publications. His Organizational Ethics is in its second edition, also with Sage. He is co-author with Michael Hackman of the popular textbook on leadership, Leadership: A Communication Perspective. Duane M. Covrig, Professor of Leadership and Ethics at Andrews University, interviewed Dr. Johnson
Comparison of staphylococcus aureus isolates from bovine and human skin, milking equipment, and bovine milk by phage typing, pulsed-field gel electrophoresis, and binary typing
No full textStaphylococcus aureus isolates (n = 225) from bovine teat skin, human skin, milking equipment, and bovine milk were fingerprinted by pulsed-field gel electrophoresis (PFGE). Strains were compared to assess the role of skin and milking equipment as sources of S. aureus mastitis. PFGE of SmaI-digested genomic DNA identified 24 main types and 17 subtypes among isolates from 43 herds and discriminated between isolates from bovine teat skin and milk. Earlier, phage typing (L. K. Fox, M. Gershmann, D. D. Hancock, and C. T. Hutton, Cornell Vet. 81:183-193, 1991) had failed to discriminate between isolates from skin and milk. Skin isolates from humans belonged to the same pulsotypes as skin isolates from cows. Milking equipment harbored strains from skin as well as strains from milk. We conclude that S. aureus strains from skin and from milk can both be transmitted via the milking machine, but that skin strains are not an important source of intramammary S. aureus infections in dairy cows. A subset of 142 isolates was characterized by binary typing with DNA probes developed for typing of human S. aureus. Typeability and overall concordance with epidemiological data were lower for binary typing than for PFGE while discriminatory powers were similar. Within several PFGE types, binary typing discriminated between main types and subtypes and between isolates from different herds or sources. Thus, binary typing is not suitable as replacement for PFGE but may be useful in combination with PFGE to refine strain differentiation
Oeming, M., & Schmid, K.\u27s Job’s journey: Stations of suffering (Book Review)
No full textOeming, M., & Schmid, K. (2015). Job’s journey: Stations of suffering. Winona Lake, IN: Eisenbrauns. 110 pp. ISBN 978157506399
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