474 research outputs found
Distinct enzymatic and cellular characteristics of two secretory phospholipases A2 in the filamentous fungus Aspergillus oryzae.
No full text
Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor
No full textWe previously demonstrated that secretory phospholipase A2 (sPLA2) and lysophosphatidylcholine (LPC) exhibit neurotrophin-like neuritogenic activity in the rat pheochromocytoma cell line PC12. In this study, we further analyzed the mechanism whereby sPLA2 displays neurite-inducing activity. Exogenously added mammalian group X sPLA2 (sPLA2-X), but not group IB and IIA sPLA2s, induced neuritogenesis, which correlated with the ability of sPLA2-X to liberate LPC into the culture media. In accordance, blocking the effect of LPC by supplementation of bovine serum albumin or phospholipase B attenuated neuritogenesis by sPLA2 or LPC. Overproduction or suppression of G2A, a G-protein-coupled receptor involved in LPC signaling, resulted in the enhancement or reduction of neuritogenesis induced by sPLA2 treatment. These results indicate that the neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2A
Transmission experiments verify sporadic V2 prion in a patient with E200K mutation
No full textNon disponibil
Relations between x-ray timing features and spectral parameters of galactic black hole x-ray binaries
No full textWe present a study of correlations between spectral and timing parameters for a sample of black hole X-ray binary candidates. Data are taken from GX
339-4, H 1743-322, and XTE J1650-500, as the Rossi X-ray Timing Explorer
(RXTE) observed complete outbursts of these sources. In our study we investigate outbursts that happened before the end of 2009 to make use of the high-energy coverage of the HEXTE detector and select observations that
show a certain type of quasi-periodic oscillations (type-C QPOs). The spectral parameters are derived using the empirical convolution model simpl to model the Comptonized component of the emission together with a disc blackbody for the emission of the accretion disc. Additional spectral features, namely a reflection component, a high-energy cut-off, and excess emission at 6.4 keV, are taken into account. Our investigations confirm the known positive
correlation between photon index and centroid frequency of the QPOs and reveal an anti-correlation between the fraction of up-scattered photons and the QPO frequency. We show that both correlations behave as expected in the “sombrero”
geometry. Furthermore, we find that during outburst decay the correlation between photon index and QPO frequency follow a general track, independent of individual outbursts
On the masses and evolutionary status of the black hole binary GX 339-4: a twin system of XTE J1550-564?
No full textWe apply the K-correction to the black hole low-mass X-ray binary (LMXB) GX 339-4 which implies MX? 6 M? by only assuming that the companion is more massive than ?0.17 M?, the lower limit allowed by applying a ‘stripped-giant’ model. This evolutionary model successfully reproduces the observed properties of the system. We obtain a maximum mass for the companion of M2? 1.1 M? and an upper limit to the mass ratio of q(=M2/MX) ? 0.125. The high X-ray activity displayed by the source suggests a relatively large mass transfer rate which, according to the model, results in M2? 0.3 M? and MX? 7 M?. We have also applied this scenario to the black hole binary XTE J1550-564, which has a similar orbital period but the donor is detected spectroscopically. The model successfully reproduces the observed stellar parameter
Synthesis of multifunctional clustered nano-Fe3O4 chitosan nanocomposite for biomedical applications
No full textMUC4 and MUC1 Expression in Adenocarcinoma of the Stomach Correlates with Vessel Invasion and Lymph Node Metastasis: An Immunohistochemical Study of Early Gastric Cancer
No full text博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Yukihiro Tamura, Michiyo Higashi, Sho Kitamoto, Seiya Yokoyama, Masahiko Osako, Michiko Horinouchi, Takeshi Shimizu, Mineo Tabata, Surinder K. Batra, Masamichi Goto, Suguru Yonezawa
MUC4 and MUC1 Expression in Adenocarcinoma of the Stomach Correlates with Vessel Invasion and Lymph Node Metastasis: An Immunohistochemical Study of Early Gastric Cancer
PLOS ONE(2012), 7(11) e4925
- …
