307 research outputs found
Utility of 18F-DCFPyL PET for local staging for high or very high risk prostate cancer for patients undergoing radical prostatectomy
No full textPurpose: PSMA PET offers the potential for improved local staging prior to radical prostatectomy (RP). We evaluated PSMA PET versus mpMRI for local and nodal staging for patients with localized NCCN high or very high risk prostate cancer undergoing RP. Methods: A prospective single center pilot study was conducted from 9/2018 to 6/2022. Patients underwent both mpMRI and 18F-DCFPyL PSMA PET with limited MRI sequences, followed by RP with pelvic lymphadenectomy. Patient and side-specific performance of mpMRI and PSMA PET were compared to RP histopathological standard of truth for extraprostatic extension (EPE), seminal vesicle invasion (SVI), and lymph node involvement (LNI). Results: At RP, 79% (38/48) had EPE, 31% had SVI, and 31% had LNI. At the patient level for EPE, PSMA PET had similar sensitivity (65.8% vs. 84.2%, respectively, P = 0.07) but higher specificity (80% vs. 40%, P = 0.045) compared to mpMRI, respectively. For SVI, PSMA PET had lower sensitivity (62.5% vs. 87.5%, P = 0.046) and similar specificity (87.5% vs. 90.6%, P = 0.56). For side-specific LNI, PSMA PET had higher sensitivity (50% vs. 25%, P = 0.03) and similar specificity (96.1% vs. 94.7%, P = 0.71) compared to mpMRI. Conclusion: PSMA PET offers higher specificity for EPE and higher sensitivity for LNI compared to mpMRI. PSMA PET may improve overall surgical planning, and may be combined with diagnostic mpMRI and clinicopathological variables through nomograms to further predict EPE, SVI, or LNI. Clinical trial registration: NCT03392181 https://clinicaltrials.gov/study/NCT03392181
Search for Pauli exclusion principle violating atomic transitions and electron decay with a p-type point contact germanium detector
No full textA search for Pauli-exclusion-principle-violating K-alpha electron transitions was performed using 89.5 kg-d of data collected with a p-type point contact high-purity germanium detector operated at the Kimballton Underground Research Facility. A lower limit on the transition lifetime of 5.8x10^30 seconds at 90% C.L. was set by looking for a peak at 10.6 keV resulting from the x-ray and Auger electrons present following the transition. A similar analysis was done to look for the decay of atomic K-shell electrons into neutrinos, resulting in a lower limit of 6.8x10^30 seconds at 90 C.L. It is estimated that the MAJORANA DEMONSTRATOR, a 44 kg array of p-type point contact detectors that will search for the neutrinoless double-beta decay of 76-Ge, could improve upon these exclusion limits by an order of magnitude after three years of operation. Abgrall, N; Arnquist, I J; Avignone, F T; Barabash, A S; Bertrand, F E; Bradley, A W; Brudanin, V; Busch, M; Buuck, M; Caldwell, A S; Chan, Y-D; Christofferson, C D; Chu, P -H; Cuesta, C; Detwiler, J A; Dunagan, C; Efremenko, Yu; Ejiri, H; Elliott, S R; Finnerty, P S; Galindo-Uribarri, A; Gilliss, T; Giovanetti, G K; Goett, J; Green, M P; Gruszko, J; Guinn, I S; Guiseppe, V E; Henning, R; Hoppe, E W; Howard, S; Howe, M A; Jasinski, B R; Keeter, K J; Kidd, M F; Konovalov, S I; Kouzes, R T; LaFerriere, B D; Leon, J; MacMullin, J; Martin, R D; Massarczyk, R; Meijer, S J; Mertens, S; Orrell, J L; O'Shaughnessy, C; Poon, A W P; Radford, D C; Rager, J; Rielage, K; Robertson, R G H; Romero-Romero, E; Shanks, B; Shirchenko, M; Suriano, A M; Tedeschi, D; Trimble, J E; Varner, R L; Vasilyev, S; Vetter, K; Vorren, K; White, B R; Wilkerson, J F; Wiseman, C; Xu, W; Yakushev, E; Yu, C -H; Yumatov, V; Zhitnikov,
How Elitism Undermines the Study of Voter Competence
No full textA form of elitism undermines much writing on voter competence. The elitist move occurs when an author uses a self-serving worldview as the basis for evaluating voters. Such elitism is apparent in widely cited measures of “political knowledge” and in common claims about what voters should know. The elitist move typically limits the credibility and practical relevance of the analysis by leading writers to draw unreliable conclusions about voter competence. I propose a more constructive way of thinking about what voters know. Its chief virtue is its consistency with basic facts about the relationship between information and choice.information; search; competence; political knowledge; public policy
Sincere, strategic, and heuristic voting under four election rules: An experimental study
No full textNous rendons compte d'une série d'expériences de laboratoire à propos des comportements de vote. Dans une situation où les sujets ont des préférences unimodales nous observons que le vote à un tour et le vote à deux tours génèrent des effets significatifs de dépendance du chemin, alors que le vote par approbation élit toujours le vainqueur de Condorcet et que le vote unique transférable (système de Hare) ne l'élit jamais. A partir de l'analyse des données individuelles nous concluons que les électeurs se comportent de manière stratégique tant que les calculs stratégiques ne sont pas trop complexes, auquel cas ils se repose sur des heuristiques simples.Elections, comportement de vote.
Political Polling in the Digital Age: The Challenge of Measuring and Understanding Public Opinion
No full textThe 2008 presidential election provided a perfect storm for pollsters. A significant portion of the population had exchanged their landlines for cellphones, which made them harder to survey. Additionally, a potential Bradley effect -- in which white voters misrepresent their intentions of voting for or against a black candidate -- skewed predictions, and aggressive voter registration and mobilization campaigns by Barack Obama combined to challenge conventional understandings about how to measure and report public preferences. In the wake of these significant changes, Political Polling in the Digital Age, edited by Kirby Goidel, offers timely and insightful interpretations of the impact these trends will have on polling.
In this groundbreaking collection, contributors place recent developments in public-opinion polling into a broader historical context, examine how to construct accurate meanings from public-opinion surveys, and analyze the future of public-opinion polling. Notable contributors include Mark Blumenthal, editor and publisher of Pollster.com; Anna Greenberg, a leading Democratic pollster; and Scott Keeter, director of survey research for the Pew Research Center.
In an era of increasingly personalized and interactive communications, accurate political polling is more difficult and also more important. Political Polling in the Digital Age presents fresh perspectives and relevant tactics that demystify the variable world of opinion taking.https://repository.lsu.edu/facultybooks/1471/thumbnail.jp
High School Policy Debate as an Enduring Pathway to Political Education: Evaluating Possibilities for Political Learning
No full textThis paper addresses the role competitive high school policy debate participation has on key developmental markers of political learning. As identified by the Carnegie Foundation’s Political Engagement Project (PEP), political learning includes political knowledge and understanding, political identity, and the development of political skills. Based in interviews with former high school debaters, the results of this study suggest there may be a transformative, politically enduring and engaging experience surrounding policy debate.
Using grounded theory to extract analysis of debaters’ experiences, this study demonstrates how sustained competitive high school policy debate experience directly advances political learning and should be a tool to engage students politically. Debaters tend to focus on issues rather than partisan politics, consider themselves well informed on issues of national and international importance, incorporate reflexive political identities, feel their daily lives and activities manifest political actions, and have increased comfort levels employing political advocacy skills including the articulation and design of political argumentation. To respond to a paradoxically increasing partisan and apolitical world, policy debate encourages high school students to access critical concepts of political engagement
Using cavity ring-down spectroscopy to measure trace impurities in noble gases for dark matter detection
No full textZukin, C – Keeter, S. – Andolina, M. – Jenkins, K. – Delli Carpini, M. X.: A New Engagement? Political Participation, Civic Life, and the Changing American Citizen
No full textKnižní recenze / Book review.Knižní recenze / Book review
What Citizens Know Depends on How You Ask Them: Political Knowledge and Political Learning Skills
No full textSurveys provide widely-cited measures of political knowledge. Do unusual aspects of survey interviews reduce their relevance? To address this question, we embedded a set of experiments in a representative survey of over 1200 Americans. A control group answered political knowledge questions in a typical survey context. Respondents in treatment groups received the same questions in different contexts. One group received a monetary incentive for answering questions correctly. Others were given more time to answer the questions. The treatments increase the number of correct answers by 11-24 percent. Our findings imply that conventional knowledge measures confound respondents’ recall of political information and their motivation to engage the survey question. The measures also provide unreliable assessments of respondents’ abilities to access information that they have stored in places other than their immediately available memories. As a result, existing knowledge measures likely underestimate peoples’ capacities for informed decision making.political knowledge; economic knowledge; experimental economics; incentives; survey
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