90 research outputs found
Use of Oral Anticoagulation and Diabetes Do Not Inhibit the Angiogenic Potential of Hypoxia Preconditioned Blood-Derived Secretomes
No full textPatients suffering from tissue ischemia, who would greatly benefit from angiogenesis-promoting therapies such as hypoxia preconditioned blood-derived secretomes commonly receive oral anticoagulation (OA) and/or have diabetes mellitus (DM). In this study, we investigated the effect of OA administration on the in vitro angiogenic potential of hypoxia preconditioned plasma (HPP) and serum (HPS), prepared from nondiabetic/diabetic subjects who did not receive OA (n = 5) or were treated with acetylsalicylic acid (ASA, n = 8), ASA + clopidogrel (n = 10), or nonvitamin K antagonist oral anticoagulants (n = 7) for longer than six months. The effect of DM was differentially assessed by comparing HPP/HPS obtained from nondiabetic (n = 8) and diabetic (n = 16) subjects who had not received OA in the past six months. The concentration of key proangiogenic (vascular endothelial growth factor or VEGF) and antiangiogenic (thrombospondin-1 or TSP-1 and platelet factor-4 or PF-4) protein factors in HPP/HPS was analyzed via ELISA, while their ability to induce microvessel formations was examined in endothelial cell cultures. We found that OA use significantly reduced VEGF levels in HPP, but not HPS, compared to non-OA controls. While HPP and HPS TSP-1 levels remained largely unchanged as a result of OA usage, HPS PF-4 levels were significantly reduced in samples obtained from OA-treated subjects. Neither OA administration nor DM appeared to significantly reduce the ability of HPP or HPS to induce microvessel formations in vitro. These findings indicate that OA administration does not limit the angiogenic potential of hypoxia preconditioned blood-derived secretomes, and therefore, it does not prohibit the application of these therapies for supporting tissue vascularization and wound healing in healthy or diabetic subjects
Leistungs- und Energiebedarfsoptimierter Einsatz einer Eissport-Kälteanlage mit Abwärmenutzung
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Planetary companions around the K giant stars 11 Ursae Minoris and HD 32518
No full textContext. 11 UMi and HD 32518 belong to a sample of 62 K giant stars that has been
observed since February 2004 using the 2m Alfred Jensch telescope of
the Thüringer Landessternwarte (TLS) to measure precise
radial velocities (RVs).
Aims. The aim of this survey is to investigate the dependence of planet formation
on the mass of the host star by searching for planetary companions around
intermediate-mass giants.
Methods. An iodine absorption cell was used to obtain accurate RVs for this study.
Results. Our measurements reveal that the RVs of
11 UMi show a periodic variation of 516.22 days with a semiamplitude of
K = 189.70 m s-1. An orbital solution yields a mass function of
= (3.608 ± 0.441) 10-7 solar masses ()
and an eccentricity of e = 0.083 ± 0.03.
The RV curve of HD 32518 shows sinusoidal variations with a
period of 157.54 days and a semiamplitude of K = 115.83 m s-1.
An orbital solution yields an eccentricity, e = 0.008 ± 0.03 and
a mass function, = (2.199 ± 0.235) 10-8 .
The HIPPARCOS photometry as well as our Hα core flux measurements
reveal no variability with the RV period. Thus, Keplerian motion is the most
likely explanation for the observed RV variations for both giant stars.
Conclusions. An exoplanet with a “minimum mass” of
m sin i = 10.50 ± 2.47 Jupiter masses () orbits the
K giant 11 UMi. The K1 III giant HD 32518 hosts a planetary companion with a
“minimum mass” of m sin i = 3.04 ± 0.68
in a nearly circular orbit. These are the 4th and 5th planets published from
this TLS survey
Planetary companion candidates around the K giant stars 42 Draconis and HD 139 357
No full textContext.
For the past 3 years we have been monitoring 62 K giant stars
using precise stellar radial velocity (RV) measurements
with the 2 m Alfred Jensch Telescope of the Thüringer Landessternwarte
Tautenburg (TLS).
Aims. To probe the dependence of planet formation on stellar mass
by finding planets around intermediate-mass giant stars.
Methods. We present high accuracy RV measurements of the K1.5 III
star 42 Dra and the K4 III star HD 139357. The wavelength reference for the
RV measurements was provided by an iodine absorption cell placed in the
optical path of the spectrograph.
Results.
Our measurements reveal that the time series of the radial velocity of
42 Dra shows a periodic variation of 479.1 days with a semiamplitude of
K = 112.5 m s-1. An orbital solution yields a mass function of
= (5.29 ± 0.62) 10-8 solar masses
()
and an eccentricity of e = 0.38 ± 0.06.
From our template spectra, taken without the iodine cell, we determine a
metallicity of -0.46 ± 0.04 dex and a stellar mass of
0.98 ± 0.06 for this star.
HD 139 357 shows periodic RV variations of
1125.7 days with a semiamplitude K = 159.9 m s-1. An orbital solution
yields an eccentricity, e = 0.10 ± 0.02 and mass
function, = (4.79 ± 0.57) 10-7 .
An iron abundance of -0.13 ± 0.04 dex is obtained, and a stellar mass
of 1.31 ± 0.24 for the parent star is derived.
An analysis of the HIPPARCOS photometry as well as our Hα
core flux measurements reveal no variability with the radial velocity
period. Keplerian motion is the most likely explanation for the
observed radial velocity variations for these stars.
Conclusions.
The K giant stars 42 Dra and HD 139 357 host extrasolar planets with
“minimum masses” of 3.88 ± 0.85 Jupiter masses
and
9.76±2.15 , respectively
Tuner performance in the S1-Global cryomodule
No full textS1-Global is a collaborative effort of INFN, DESY, FNAL, SLAC and KEK, in the framework of the ILC global collaboration. For this project two cryomodules, 6 meter long and hosting four SC cavities each, were realized and successfully cold tested at KEK-STF. Three different cavity tuning systems, provided with fast tuning capability through piezoelectric actuators (piezo), were installed, and fully characterized in static and dynamic operation: Blade Tuner from INFN/FNAL, Saclay Tuner from DESY, Slide Jack Tuner from KEK. Finally, Lorenz Force Detuning (LFD) active compensation has been successfully achieved during high power cavity tests in pulsed RF regime, where active control of the LFD disturbance up to Hz-level residual detuning has been achieved with each type of tuning system up to the maximum gradient of each cavity. The installation procedures, together with the relevant results and their analyses are summarized in the paper
Numerical Investigation of Leading Edge Blowing and Optimization of the Slot Geometry for a Circulation Control Airfoil
No full textFeldarbeiten 1966/67
No full textKAISER, K.: Der känozoische Vulkanismus im Tibesti-Gebirge ; BRUSCHEK, G. 1.: Soborom — Souradom — Tarso Voon. — Vulkanische Bauformen im zentralen Tibesti-Gebirge — und die postvulkanischen Erscheinungen von Soborom ; KAISER, K.: Prozesse und Formen der ariden Verwitterung am Beispiel des Tibesti-Gebirges und seiner Rahmenbereiche ; KALLENBACH, H.: Petrographie ausgewählter quartärer Lockersedimente und eisenreicher Krusten der libyschen Sahara ; BUSCHE, D.: Vorläufiger Bericht über Untersuchungen an Schwemmfächern auf der Nordabdachung des Tibestigebirges, République du Tchad ; GRUNERT, J.: Die jungpleistozänen und holozänen Flußterrassen des oberen Enneri Yebbigué im zentralen Tibesti-Gebirge (Rép. du Tchad) und ihre klimatische Deutung ; MESSERLI, B.; ZURBUCHEN, M. und INDERMÜHLE, D.: Emi Koussi-Tibesti: Eine topographische Karte vom höchsten Berg der Sahara ; HECKENDORFF, W. D.: Zum Klima des Tibesti-Gebirges ; HERRMANN, B. und GABRIEL, B.: Untersuchungen an vorgeschichtlichem Skelettmaterial aus dem Tibestigebirge (Sahara) ; GABRIEL, B.: Neuere Ergebnisse der Vorgeschichtsforschung in der östlichen Zentralsahara ; Verzeichnis der Wissenschaftlichen Arbeiten aus der Forschungsstation BardairesearchDFG, SUB Göttingen, FU Berli
Aerodynamic Aspects of the Longitudinal Motion of a High-Lift Aircraft Configuration with Circulation Control
No full textThe aim of sub-project C1 of the Collaborative Research Center/Sonderforschungsbereich 880 (SFB 880) is to investigate numerically the flight mechanical characteristics of an aircraft with circulation controlled high-lift devices from an aerodynamic point of view. This paper summarizes the most important aspects of the work done so far. It begins with a basic analysis of the impact of varying blowing coefficients on the aircraft performance based on the wing-body configuration. Furthermore, an overview of the influence of the circulation controlled wing on the aerodynamics of the horizontal tail plane is presented. Eventually, the resulting longitudinal static stability and controllability behavior of the SFB 880’s reference aircraft is discussed. Additionally, the interaction of a circulation controlled wing and the slipstream of a wing mounted turboprop engine is investigated. Besides the studies of the static behavior, first results of the dynamic behavior, specifically the temporal behavior of circulation control after being activated are presented
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