132 research outputs found
Design and fabrication of an electrostatically driven microgripper for blood vessel manipulation
No full textLymphatic capillary hypoplasia in the skin of fetuses with increased nuchal translucency and Turner's syndrome: comparison with trisomies and controls
No full textFetuses with Turner's syndrome or trisomies 21, 18 and 13 show excess of skin, which can be visualized by ultrasonography as increased nuchal translucency at 11-13(+6) weeks' gestation. The objective of this study was to gain insight in the development and distribution of blood vessels, lymphatic capillaries of the cutis and lymphatic collectors of the cutis and subcutis and to study developmental changes with increasing gestation. Immunofluorescence of cryosections with 10 specific antibodies was used to investigate the nuchal skin of three fetuses with Turner syndrome's and to differentiate lymphatics, lymph capillaries (FLT4, PTN 63, LYVE1, PROX1), blood vessels (KDR, CD 31, PDPN), blood clotting activity (von Willebrand factor), basement membranes and big vessels (Laminin, Collagen Type IV). The findings were compared with those in seven fetuses with trisomy 21 and two fetuses each with trisomies 18 or 13, respectively, as well as six normal controls. Immunoreactive receptors for vascular endothelial growth factors (FLT4) were decreased in lymphatic capillaries of the skin of Turner fetuses. Accordingly, LYVE1 was scarce and PROX1 staining was less intense in the dermis of Turner fetuses. Lymphatic collectors were, however, evenly stained. In normal fetuses and in those with trisomies, lymphatic capillaries were evenly distributed. We conclude that lymphatic capillary hypoplasia might be responsible for nuchal cystic hygroma in Turner syndrome. The biological basis for increased nuchal translucency in trisomies may however be different
Real-world evidence from a European cohort study of patients with treatment resistant depression: Healthcare resource utilization
No full textBackground: Treatment resistant depression (TRD) is diagnosed when patients experiencing a major depressive episode fail to respond to ≥2 treatments. Along with substantial indirect costs, patients with TRD have higher healthcare resource utilization (HCRU) than other patients with depression. However, research on the economic impact of this HCRU, and differences according to response to treatment, is lacking. Methods: This multicenter, observational study documented HCRU among patients with TRD in European clinical practice initiating new antidepressant treatments. Data regarding access to outpatient consultations and other healthcare resources for the first 6 months, collected using a questionnaire, were analyzed qualitatively according to response and remission status. The economic impact of HCRU, estimated using European costing data, was analyzed quantitatively. Results: Among 411 patients, average HCRU was higher in non-responders, attending five times more general practitioner (GP) consultations and spending longer in hospital (1.7 versus 1.1 days) than responders. Greater differences were observed according to remission status, with non-remitters attending seven times more GP consultations and spending approximately three times longer in hospital (1.7 versus 0.6 days) than remitters. Consequently, the estimated economic impacts of non-responders and non-remitters were significantly greater than those of responders and remitters, respectively. Limitations: Key limitations are small cohort size, absence of control groups and generalizability to different healthcare systems. Conclusion: Patients with TRD, particularly those not achieving remission, have considerable HCRU, with associated economic impact. The costs of unmet TRD treatment needs are thus substantial, and treatment success is fundamental to reduce individual needs and societal costs
Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics
No full textBackground: Treatment resistant depression (TRD; failure to respond to ≥2 treatments) affects ~20% of patients with major depressive disorder (MDD). Real-world data could help describe patient characteristics and TRD disease burden, to assess the unmet needs of TRD patients in Europe. Methods: This observational study collected data from adults with moderate to severe TRD initiating a new treatment for depression, according to local standards of care. At baseline, socio-demographic characteristics, medical history, prior and current treatments were recorded. Disease severity, health-related quality of life (HRQoL), functionality and productivity were assessed. Results: Overall, 411 eligible patients were enrolled across seven European countries. Mean (standard deviation [SD]) patient age was 51.0 (10.8) years; 62.3% were female. Long-term sick leave was reported by 19.0% of patients; 30.2% were unemployed. The mean (SD) duration of the current episode was 2.6 (3.9) years. At baseline, mean (SD) HRQoL scores for EuroQoL 5-dimension 5-level (UK tariff) and EQ-Visual Analog Scale were 0.41 (0.25) and 41.1 (18.7), respectively. The Work Productivity and Activity Impairment questionnaire demonstrated mean (SD) absenteeism of 57.0% (44.9%) and presenteeism of 54.7% (29.5%); mean (SD) overall work impairment was 60.5% (29.9%). Limitations: Key limitations are small cohort size, absence of a control group and generalizability to countries with different healthcare models. Conclusions: TRD patients had a high disease burden, low HRQoL and reduced function and productivity, with a substantial proportion unable to work. This demonstrates an unmet treatment need in TRD patients that, if addressed, could reduce the heavy personal and societal burden
Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes
No full textBackground: Treatment resistant depression (TRD) characterizes a subgroup of 10–30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. Methods: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. Results: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. Conclusions: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe
The Filter Imager SuFI and the Image Stabilization and Light Distribution System ISLiD of the Sunrise Balloon-Borne Observatory: Instrument Description
No full textWe describe the design of the Sunrise Filter Imager (SuFI) and the Image Stabilization and Light Distribution (ISLiD) unit onboard the Sunrise balloon borne solar observatory. This contribution provides the necessary information which is relevant to understand the instruments' working principles, the relevant technical data, and the necessary information about calibration issues directly related to the science data. © 2010 The Author(s)
Dissecting the donor star in the eclipsing polar HU Aquarii
No full textMedium-resolution spectroscopic observations with full phase coverage of the eclipsing polar HU Aqr are presented. Na I absorption and Ca II emission lines are used to trace the secondary star. While the Na I lines seem to have contributions from both hemispheres of the donor star, the Ca II lines were found to originate from the irradiated part of its surface alone. An irradiation model was applied and the irradiation-weighted radial velocity amplitude was used to determine the mass ratio Q = M(WD)/M(2) = 4.58 +/- 0.20. When combined with high-speed photometric low-state eclipse light curves, the white dwarf mass is constrained to 0.75 < M(WD)/M(circle dot) < 0.84 with a best-fit value of M(WD) = (0.80 +/- 0.04) M(circle dot), and M(2) = (0.18 +/- 0.06) M(circle dot) at an orbital inclination of i = 87(-0.5)(o+0.8)
In-flight calibration of Metis coronagraph on board of Solar Orbiter
No full textMetis coronagraph is one of the remote-sensing instruments of the Solar Orbiter mission launched at the begin of 2020. The mission profile will allow for the first time the remote-sensing observation of the Sun from a very close distance and increasing the latitude with respect to the ecliptic plane. In particular, Metis is aimed at the overall characterization and study of the solar corona and solar wind. Metis instrument acquires images of the solar corona in two different wavelengths simultaneously; ultraviolet (UV) and visible-light (VL). The VL channel includes a polarimeter with an electro-optically modulating Liquid Crystal Variable Retarder (LCVR) to measure the linearly polarized brighness pB) of the K-corona. This paper presents part of the in-flight calibration results for both wavelength channels together with a comparison with on-ground calibrations. The orientation of the K-corona linear polarization was used for the in-flight calibration of the Metis polarimeter. This paper describes the correction of the on-ground VL vignetting function after the in-flight adjustment of the internal occulter. The same vignetting function was adaptated to the UV channel
In-flight calibration of Metis coronagraph on board of Solar Orbiter
No full textMetis coronagraph is one of the remote-sensing instruments of the Solar Orbiter mission launched at the begin of 2020. The mission profile will allow for the first time the remote-sensing observation of the Sun from a very close distance and increasing the latitude with respect to the ecliptic plane. In particular, Metis is aimed at the overall characterization and study of the solar corona and solar wind. Metis instrument acquires images of the solar corona in two different wavelengths simultaneously; ultraviolet (UV) and visible-light (VL). The VL channel includes a polarimeter with an electro-optically modulating Liquid Crystal Variable Retarder (LCVR) to measure the linearly polarized brighness pB) of the K-corona. This paper presents part of the in-flight calibration results for both wavelength channels together with a comparison with on-ground calibrations. The orientation of the K-corona linear polarization was used for the in-flight calibration of the Metis polarimeter. This paper describes the correction of the on-ground VL vignetting function after the in-flight adjustment of the internal occulter. The same vignetting function was adaptated to the UV channel
Identifizierung neuer molekularer Marker des serösen Ovarialkarzinoms mit dem Potential als therapeutische Targets sowie als Serummarker zur Früherkennung
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