1,721,153 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Metabolic and functional role of the ceramide binding protein CERT in glioma cells
No full textDifferent studies demonstrate that in glial cells ceramide
(Cer) exerts antiproliferative and proapoptotic effects, and
strongly support that Cer-signalling is altered in glial
tumors. The control of ceramide levels in glial cells
involves specific enzymes which are known to be localized
in different subcellular compartments as well as Cer
movements along the sphingomyelin biosynthetic pathway.
A key element in defining the role of Cer in sphingolipid
metabolism and signalling is its hydrophobic nature, and its
consequent inability to spontaneously move among
different subcellular sites where the enzymes of its
metabolism and its molecular targets are located. Based on
this evidence, the biological effect exerted by Cer may
depend on the presence of specific signalling pools of this
bioactive sphingoid in the cell, as well as the regulation of
its intracellular traffic. Recently, the identification in CHO
cells of the Cer specific carrier protein CERT have revealed
a novel pathway for the delivery of Cer to the Golgi
apparatus for sphingomyelin biosynthesis. In this study we
investigated the metabolic and functional role of CERT in
glioma cells. All glioma cells analyzed constitutively
express CERT, the protein being mainly associated to thecytosolic fraction. Metabolic experiments performed with
different radioactive metabolic precursors of sphigolipids
indicate that, in all analyzed glioma cells, downregulation
of CERT by RNA interference technology promoted a
significant but not complete reduction of the amount of
Cer converted to SM. This suggests that in glioma cells
CERT mediated Cer transport contributes in addressing
ceramide toward sphingomyelin biosynthesis. Since the
regulation of sphingomyelin biosynthesis represents a
crucial step in the role of ceramide on glial cell
proliferation we evaluated the possible role of CERT in the
control of glioma cell proliferation. We found that in all
glioma cells down regulation of CERT resulted in an
increased cell proliferation associated to higher ERK1/2
phosphorylation. In vitro and in vivo experiments indicated
that CERT is necessary for the inhibition exerted by Cer on
ERK activation. In conclusion these results suggest that
CERT, besides the involvement in sphingolipid metabolism,
participates to Cer signalling and could play a role in the
control of glioma cell proliferation
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Ceramide traffic in C6 glioma cells: evidence for CERT-dependent and independent transport from ER to the Golgi apparatus
No full textIntracellular movements of ceramide are strongly limited by its hydrophobic nature, and the mechanisms involved in ceramide transport can
represent a crucial aspect of sphingolipid metabolism and signaling. The recent identification of the ceramide specific carrier protein CERT has
revealed a novel pathway for the delivery of ceramide to the Golgi apparatus for sphingomyelin biosynthesis. In this study we investigated the
metabolic and functional role of CERT in C6 glioma cells. These cells were found to constitutively express CERT, the protein being mainly
associated with the cytosolic fraction. Metabolic experiments performed with different radioactive metabolic precursors of sphingolipids
demonstrated that the down regulation of CERT by RNAi technology resulted in a significant but not complete reduction of ceramide metabolism
to sphingomyelin, without affecting its utilization for glycosphingolipid biosynthesis. Since nitric oxide is an inhibitor of ceramide ER-to-Golgi
traffic and metabolism in C6 glioma cells, we evaluated the possibility that the CERT-mediated transport of ceramide might represent a target for
nitric oxide. The data obtained demonstrate that CERT down regulation does not affect the inhibitory activity of nitric oxide on Cer metabolism,
and the effects of nitric oxide and CERT silencing on ceramide utilization were additive. These results strongly suggest that a CERT-mediated and
a CERT-independent, nitric oxide-sensitive Cer transport coexist in C6 glioma cells and can separately contribute to the control of sphingolipid metabolism and Cer levels in these cells
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