106,524 research outputs found
K maximum probability attack paths generation algorithm for target nodes in networked systems
No full textAs known, security system administrators need to be aware of the security risks and abnormal behaviors in a network system. Given the exploitation probability value of each vulnerability, the cumulative probability of an attack path from an attacker to a target node can be quantified and calculated, namely as the K maximum probability attack paths for a target node. It is proposed in this paper a design to compute the K maximum probability attack paths for a given set of target nodes, where available vulnerability sets for each node in the system are built and assigned to different access flags during the computation process of attack paths, aimed at reducing the computation costs. Experimental results show that the proposed design can improve the performance on the computation of the K maximum probability attack paths for a given set of target nodes, promising and more efficient than existing algorithms to generate the attack paths
Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling
No full textThe Tcf/Lef family of transcription factors mediates the Wnt/��-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and diverse pathogenesis. Post-translational modifications, including phosphorylation, sumoylation and acetylation, are known to be important for the regulation of Tcf/Lef proteins. However, the importance of ubiquitination and ubiquitin-mediated regulatory mechanisms for Tcf/Lef activity are still unclear. Here, we newly show that ubiquitin C-terminal hydrolase 37 (Uch37), a deubiquitinase, interacts with Tcf7 (formerly named Tcf1) to activate Wnt signalling. Biochemical analyses demonstrated that deubiquitinating activity of Uch37 is not involved in Tcf7 protein stability but is required for the association of Tcf7 to target gene promoter in both Xenopus embryo and human liver cancer cells. In vivo analyses further revealed that Uch37 functions as a positive regulator of the Wnt/��-catenin pathway downstream of ��-catenin stabilization that is required for the expression of ventrolateral mesoderm genes during Xenopus gastrulation. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/��-catenin pathway. ? 2017 The Author(s).113Ysciescopu
Vibration Characteristics of Pre and Post Buckled Laminated Composite Spherical Shells
No full textThis work was supported by Defense Acquisition Program Administration and Agency for the
Defense Development under the contract UD060009AD. The first author thanks the support of
the second stage of the Brain Korea 21 project in 2007
sj-pdf-1-han-10.1177_15589447211038679 – Supplemental material for Gender Diversity in Hand Surgery Leadership
No full textSupplemental material, sj-pdf-1-han-10.1177_15589447211038679 for Gender Diversity in Hand Surgery Leadership by Alyssa K. Brisbin, Wendy Chen, Ezequiel Goldschmidt, Brandon T. Smith and Debra A. Bourne in HAND</p
Infrared matrix isolation study of acetone and methanol in solid argon
No full textThe infrared absorption spectra of acetone and methanol mixtures have been investigated in a solid argon matrix at 9 K. A number of intramolecular complex bands were observed both in the acetone and methanol fundamental regions. From the concentration dependence of the infrared spectral pattern, acetone and methanol seemed to form a 1:1 binary complex. Noticeable red-shifts of the C=O stretching mode of acetone as well as the O-H stretching mode of methanol suggest that the two molecules are bound mainly through a H-bond between the carbonyl oxygen and the hydroxyl hydrogen atoms. A relatively weaker H-bonded interaction appeared also to act between the oxygen atom of methanol and a hydrogen atom of acetone. This view was found to be consistent with ab initio SCF, MP2, and DFT level computations. The most stable structure calculated was found to possess those two kinds of H-bonds, assuming a planar six-membered ring-like structure
Determination of K shell XRF parameters and K to L shell vacancy transfer probabilities of ferromagnetic 3d transition metals
No full textIn this study, K shell X-ray fluorescence cross-sections (sigma K alpha, sK beta and sigma K), K shell fluorescence yields (omega K) and K to L shell vacancy transfer probabilities (eta KL) of ferromagnetic 3d transition metals (Fe, Co, Ni) were investigated to understand how the relationship between ferromagnetism and these values changes with atomic number by using energy dispersive X-ray fluorescence (EDXRF) technique. The all obtained experimental and theoretical results were comparatively given as a function of the atomic number. It was clearly observed that all of the investigated parameters depend on the atomic number and the ferromagnetism state of the atom
Self-assembled monolayers of aromatic thiol and selenol on silver: Comparative study of adsorptivity and stability
No full textWe have investigated comparative adsorptivities and relative stabilities of self-assembled monolayers of thiol (benzenethiol, BT) vs selenol (benzeneselenol, BSe) on a silver surface by diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy and surface-enhanced Raman spectroscopy (SERS). BT and BSe are chemisorbed on silver as benzenethiolate and benzeneselenolate, respectively, after deprotonation with a tilted orientation with respect to the substrate surface; the benzene rings of BT and BSe are tilted by 25 degrees and 37 degrees, respectively, from the substrate normal. Competitive adsorption experiments show that adsorption of BT is more favorable by 0.3 kcal/mol. Temperature-dependent DRIFT spectra indicated that the monolayer of benzenethiolate on silver is thermally more stable than that of benzeneselenolate. This could be evidenced from the fact that the vibrational peaks of the benzenethiolate species were observed up to 458 K, while those of benzeneselenolate became substantially weakened around 418 K. The more negative desorption potential of the BT monolayer clearly indicates that the benzenethiolate binds more strongly to the silver surface than the benzeneselenolate does
Dataset to support the article "High-resolution 𝜙-OFDR using phase unwrap and nonlinearity suppression"
No full textThis dataset is used for realizing high resolution of phase-sensitive Optical Frequency Domain Reflectometer. It is associated with the research paper:
Guo Z, Yan J, Han G, Yu Y, Greenwood D and Marco J (2023) "High-Resolution φ-OFDR Using Phase Unwrap and Nonlinearity Suppression". Journal of Lightwave Technology, 41 (9), 2885-2891. (https://doi.org/10.1109/JLT.2023.3236775).
The data is presented as an excel file:
High_resolution_OFDR_using_phase_unwrap_and_nonlinearity_suppression.xlsx
This work was funded by High Value Manufacturing Catapult and the Engineer and Physical Sciences Research Council - EPSRC EP/V000624/1. The author Gaoce Han would like to acknowledge the China Scholarship Council for sponsoring.</span
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