61,954 research outputs found
K maximum probability attack paths generation algorithm for target nodes in networked systems
No full textAs known, security system administrators need to be aware of the security risks and abnormal behaviors in a network system. Given the exploitation probability value of each vulnerability, the cumulative probability of an attack path from an attacker to a target node can be quantified and calculated, namely as the K maximum probability attack paths for a target node. It is proposed in this paper a design to compute the K maximum probability attack paths for a given set of target nodes, where available vulnerability sets for each node in the system are built and assigned to different access flags during the computation process of attack paths, aimed at reducing the computation costs. Experimental results show that the proposed design can improve the performance on the computation of the K maximum probability attack paths for a given set of target nodes, promising and more efficient than existing algorithms to generate the attack paths
Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling
No full textThe Tcf/Lef family of transcription factors mediates the Wnt/��-catenin pathway that is involved in a wide range of biological processes, including vertebrate embryogenesis and diverse pathogenesis. Post-translational modifications, including phosphorylation, sumoylation and acetylation, are known to be important for the regulation of Tcf/Lef proteins. However, the importance of ubiquitination and ubiquitin-mediated regulatory mechanisms for Tcf/Lef activity are still unclear. Here, we newly show that ubiquitin C-terminal hydrolase 37 (Uch37), a deubiquitinase, interacts with Tcf7 (formerly named Tcf1) to activate Wnt signalling. Biochemical analyses demonstrated that deubiquitinating activity of Uch37 is not involved in Tcf7 protein stability but is required for the association of Tcf7 to target gene promoter in both Xenopus embryo and human liver cancer cells. In vivo analyses further revealed that Uch37 functions as a positive regulator of the Wnt/��-catenin pathway downstream of ��-catenin stabilization that is required for the expression of ventrolateral mesoderm genes during Xenopus gastrulation. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/��-catenin pathway. ? 2017 The Author(s).113Ysciescopu
sj-docx-1-han-10.1177_15589447211068183 – Supplemental material for Repeat Irrigation and Debridement of Upper Extremity Infections: Do Repeat Cultures Change Antibiotic Treatment Regimens?
No full textSupplemental material, sj-docx-1-han-10.1177_15589447211068183 for Repeat Irrigation and Debridement of Upper Extremity Infections: Do Repeat Cultures Change Antibiotic Treatment Regimens? by Bradley D. Wiekrykas, Jeffrey C. Wera, Gavin Rallis and Mark K. Solarz in HAND</p
Cognitive responses to favor request from social targets of different relationships in a Confucian society
No full textInfrared matrix isolation study of acetone and methanol in solid argon
No full textThe infrared absorption spectra of acetone and methanol mixtures have been investigated in a solid argon matrix at 9 K. A number of intramolecular complex bands were observed both in the acetone and methanol fundamental regions. From the concentration dependence of the infrared spectral pattern, acetone and methanol seemed to form a 1:1 binary complex. Noticeable red-shifts of the C=O stretching mode of acetone as well as the O-H stretching mode of methanol suggest that the two molecules are bound mainly through a H-bond between the carbonyl oxygen and the hydroxyl hydrogen atoms. A relatively weaker H-bonded interaction appeared also to act between the oxygen atom of methanol and a hydrogen atom of acetone. This view was found to be consistent with ab initio SCF, MP2, and DFT level computations. The most stable structure calculated was found to possess those two kinds of H-bonds, assuming a planar six-membered ring-like structure
sj-docx-2-han-10.1177_15589447231198268 – Supplemental material for Outcomes Following Surgical Interventions for Isolated Lunotriquetral Interosseous Ligament Injuries: A Systematic Review
No full textSupplemental material, sj-docx-2-han-10.1177_15589447231198268 for Outcomes Following Surgical Interventions for Isolated Lunotriquetral Interosseous Ligament Injuries: A Systematic Review by Mohanad Omar-Hossein, Jacob C. K. Leung, Joyce Munaku, Danielle Rodzik, Armaghan Dabbagh and Mike Szekeres in HAND</p
sj-docx-1-han-10.1177_15589447231167579 – Supplemental material for Two Thumbs Down: A 10-Year Analysis of Crossbow-Related Hand and Digit Injuries in the United States
No full textSupplemental material, sj-docx-1-han-10.1177_15589447231167579 for Two Thumbs Down: A 10-Year Analysis of Crossbow-Related Hand and Digit Injuries in the United States by Nicholas C. Oleck, Bryan J. Pyfer, Miranda X. Morris and Suhail K. Mithani in HAND</p
The Effects of Postannealing Treatment in Forming Gas on Low-k SiOC(H) Film
No full textThe effects of postannealing treatment in ambient forming gas (10% H(2):90%N(2)) on low-k SiOC(H) films deposited by plasma-enhanced chemical vapor deposition were investigated. The use of SiOC (H) films has certain advantages due to the presence of alkyl groups in the film, which result in improved hardness properties, compared with previously reported low-k materials. Metal-oxide-semiconductor capacitance-voltage measurements at 100 kHz indicated that the relative dielectric constant (k-value) of the as-grown film was approximately 2.4. When rapid thermal annealing (RTA) temperatures of up to 500 degrees C were used, the Si-O-C bonds were nearly maintained when the annealing was conducted using an ambient of forming gas, whereas they substantially decreased in an ambient of N(2) gas. The decrease in Si-O-C bond content results in an increase in k-value. In the film that underwent an RTA treatment at 600 degrees C, the alkyl groups of the film were released and the Si-O network was enhanced in both ambient gases, which has a critical effect on the change in k-value. (C) 2010 The Electrochemical Society. [DOI: 10.1149/1.3439670] All rights reserved.113sciescopu
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