94 research outputs found
Ordervrijgave aan de hand van een digitaal vrijgave systeem
No full textDe begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie.
The supervisor and/or the author did not authorize public publication of the thesis.
The effects of teaching roots and affixes on the vocabulary development of underperforming students
No full textRecent STAR testing results show that California students are not performing well on the English/Language Arts portion of the examination (California Department of Education, 2008). Many underperforming students, including English Learners, have difficulty with the plethora of unfamiliar vocabulary words found in such examinations, as well as in their regular schoolwork. Since these students have to pass the California High School Exit Exam (CAHSEE) to graduate from high school, they need to be taught strategies that will assist them in decoding and comprehending foreign vocabulary words. The skills they learn in K-12 education will help students have successful futures. Information was obtained through the program and coursework as well as research of the pertinent and relevant literature. Other data was collected through the observation and testing of two junior high school English classrooms. Results of a pre and posttest suggested students who were given explicit instruction in roots and affixes performed better than those who did not receive explicit instruction. Results also showed students responded well to games and activities meant to motivate them to academic success
The effects of teaching roots and affixes on the vocabulary development of underperforming students
No full textThesis (M.A., Education (Curriculum and Instruction)) -- California State University, Sacramento, 2009.Recent STAR testing results show that California students are not performing\ud
well on the English/Language Arts portion of the examination (California Department\ud
of Education, 2008). Many underperforming students, including English Learners,\ud
have difficulty with the plethora of unfamiliar vocabulary words found in such\ud
examinations, as well as in their regular schoolwork. Since these students have to pass\ud
the California High School Exit Exam (CAHSEE) to graduate from high school, they\ud
need to be taught strategies that will assist them in decoding and comprehending\ud
foreign vocabulary words. The skills they learn in K-12 education will help students\ud
have successful futures. Information was obtained through the program and coursework as well as\ud
research of the pertinent and relevant literature. Other data was collected through the\ud
observation and testing of two junior high school English classrooms. Results of a pre and posttest suggested students who were given explicit\ud
instruction in roots and affixes performed better than those who did not receive\ud
explicit instruction. Results also showed students responded well to games and\ud
activities meant to motivate them to academic success.Education (Curriculum and Instruction
Disappearing professions through technological development: Implications for the Dutch labour market
No full textFrey and Osborne (2013) have researched the effects of current digitization and robotization of society and concluded 47 percent of American jobs have a high probability of disappearing between now and the year 2030. There are signs that these technological developments may lead to a fourth industrial revolution and consequently, unemployment will rise, as job creation cannot keep up with job destruction. The previous Deputy Prime minister of the Netherlands underlined the necessity of dealing with the possible changes of technological development for the Netherlands (Buddingh, 2014). A quantitative database-driven approach is used to determine a labour market forecast for the Netherlands. The programming language ‘Python’ was used to conduct the research. The research concludes in a policy space with three technological development scenarios and a generalized methodology. The development scenarios are low, medium, and high technological development. The research concludes in respectively 0.8, 2.6 and 4.7 million loss of jobs for the scenarios. The loss of jobs should be regarded as a space for policy since it does not incorporate the creation of new occupations. It is recommended to the Ministry of Social Affairs and Employed to instate a committee that addresses the sketched scenarios and designs policy to mitigate possible negative effects.Engineering and Policy Analysi
The Critical View of Safety and Routine Intraoperative Cholangiography Complement Each Other as Safety Measures During Cholecystectomy
No full textSpatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures
No full text[EN] The spatiotemporal orchestration of cellular processes is a ubiquitous phenomenon in pluricellular organisms and bacterial communities, where sender cells secrete chemical signals that activate specific pathways in distant receivers. Despite its importance, the engineering and investigation of spatiotemporal communication in artificial cell consortia remains underexplored. In this study, we present spatiotemporal communication between cellular-scale entities acting as both senders and receivers. The transmitted signals are leveraged to elicit conformational alterations within compartmentalized DNA structures. Specifically, sender entities control and generate diffusive chemical signals, namely, variations in pH, through the conversion of biomolecular inputs. In the receiver population, compartmentalized DNA nanostructures exhibit changes in conformation, transitioning between triplex and duplex assemblies, in response to this pH variation. We demonstrate the temporal regulation of activated DNA nanostructures through the coordinated action of two antagonistic sender populations. Furthermore, we illustrate the transient distance-dependent activation of the receivers, facilitated by sender populations situated at defined spatial locations. Collectively, our findings provide novel avenues for the design of artificial cell consortia endowed with programmable spatiotemporal dynamics through chemical communication.The authors would like to acknowledge the support from the Dutch Ministry of Education, Culture, and Science (Gravitation programs 024.001.035, 024.003.013, 024.005.020 - Interactive Polymer Materials IPM, and the Spinoza premium), ERC Advanced Grant (Artisym 694120), ERC Advanced Grant Edison (101052997), the Spanish Ministry of Science and Innovation, AEI, and FEDER-EU (project PID2021-126304OB-C41), and the GVA (Project CIPROM/2021/007). A.L.-L. acknowledges support from the MSCA Cofund project oLife, which has received funding from the European Union's Horizon 2020 research and innovation program under the Grant Agreement 847675. A.L.-L. thanks the Spanish Government for his "Ramon y Cajal" Fellowship (RYC2021-034728-I), funded by MCIN/AEI/10.13039/501100011033 and by the European Union >/>. A.L-L. also thanks the UPV for funding (Ayuda para potenciar la investigacion postdoctoral de la UPV (PAID-PD-22), Ayuda a Primeros Proyectos de Investigacion (PAID-06-22), Vicerrectorado de Investigacion de la Universitat Politecnica de Valencia (UPV)).Llopis-Lorente, A.; Shao, J.; Ventura-Cobos, J.; Buddingh, BC.; Martínez-Máñez, R.; Van Hest, JCM.; Abdelmohsen, LKEA. (2024). Spatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures. ACS CENTRAL SCIENCE. 10(8):1619-1628. https://doi.org/10.1021/acscentsci.4c00702S1619162810
Improved outcome of HSCT in STAT1 gain-of-function disease following JAK inhibition bridging.
No full textGermline gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 () are associated with infections, including chronic mucocutaneous candidiasis and autoimmunity. Morbidity is high, and disease manifestations can be life-threatening. Curative allogeneic hematopoietic stem cell transplantation (HSCT) historically has had poor outcomes. We identified 36 patients with STAT1 GOF disease, receiving 40 HSCT procedures in 2010-2023, in a combined effort of the EBMT-IEWP and the PIDTC. Median age at first transplant was 11 years (range 1 - 33). Indications for HSCT were combined immunodeficiency, severe and/or refractory infections, and autoimmunity. Acute GvHD occurred in 22/40 HSCT procedures; 5 patients suffered from grade III/IV acute GvHD. One patient had chronic GvHD. Overall survival was 72.2%, and event-free survival was 55.6%, markedly improved from an earlier report on HSCT for STAT1 GOF disease. Patients with an HCT-CI score of 1 or higher had worse outcome. Pre-treatment with Janus kinase (JAK) inhibitors was associated with better event-free survival
Relationship between serum calcium and CA 19-9 levels in colorectal cancer
No full textAIM: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients.
METHODS: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above.
RESULTS: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined.
CONCLUSION: Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer
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