409 research outputs found
Application of Taguchi Method in the Optimization of Swimming Capability for Robotic Fish
No full textIn this paper, we applied the Taguchi method to evaluate the maximum swimming speed of a robotic fish under the limitation of the output of the motor. Four factors were considered in the optimization: the caudal-fin aspect ratio, the caudal fin stiffness, the oscillating frequency and the stiffness of the spring that transmits forces from the actuators to the foil. Because of the power limitations, the parameter's space was irregular. Since the Taguchi method requires a regular parameter space, we divided the parameter space into a regular space and the remaining irregular spaces. Within only 25 trials, the frequency and the spring stiffness were determined as the main factors in the regular space by the orthogonal design. Six more trials were carried out in the remaining irregular space with a higher frequency and spring stiffness. The fastest swimming speed of 870 mm/s, approximately 2.6 BL (Body Lengths)/s, was acquired, when the frequency reached 12Hz and with infinite spring stiffness. This method is efficient for exploring the maximum locomotor capabilities of robotic fish and may also be useful for other robots as no modelling is required
Synthesis and Tunable Optical Properties of C,N-Chelated Borate Luminophores Derived from Potassium Acyltrifluoroborates
No full textA new class of borate luminophores has been synthesized by a simple two-step reaction using potassium acyltrifluoroborates (KATs) as starting materials. The hydrazones obtained from reactions between KATs and 2-hydrazinopyridines followed by a cyclization resulted in the unprecedented formation of C,N-chelated six-membered bora-heterocycles. Under consideration of the results of DFT and TD-DFT calculations, four luminophores based on such bora-heterocycles are designed and synthesized, which exhibit a tunable fluorescence range from blue to red in the solid state. Moreover, one of the luminophores exhibits mechanofluorochromism from blue to yellow/green. As a result of the aforementioned mechanochromism of one of these luminophores, white-color emission was achieved by simply mixing the four luminophores
Abstract 921: Cdyl2 is a chromodomain protein involved in the maintenance of pluripotency of stem cells
No full textAbstract
Reader proteins of histone modifications are required to translate the information of histone marks into the cellular phenotypes, including pluripotency and malignancy. For example, a reader protein BRD4 has its target specificity and becomes a target of cancer therapy. Here, we aimed to identify reader proteins involved in the pluripotency of stem cells. Using the UCSC database, 11 genes coding chromo- or PHD-domain proteins were isolated as actively transcribed in mouse ES cells (ESCs). Among the 11 genes, Cdyl2, chromodomain protein Y-like2, was found to be down-regulated upon ESC differentiation using RT-qPCR. Immunofluorescence and ChIP assay revealed that Cdyl2 recognized H3K27me3 of the specific regions, including differentiation-associated genes. Cdyl2-knock-out ESCs could not survive after differentiation induced by LIF removal or retinoic acid because of the induction of apoptosis, indicating that Cdyl2 is important for normal differentiation of ESCs. ESC expressing exogenous Cdyl2 showed incomplete down-regulation of Oct-4 and Nanog by retinoic acid, and generated teratomas with an abnormal composition of three germ layers, showing perturbation of differentiation ability. Pathologically, aberrant expression of human CDYL2 was observed in breast cancer cell lines and primary breast cancers. Two breast cancer cell lines (MDA-MB-231 and MDA-MB-468) expressing exogenous CDYL2 showed enhanced attachment ability along with the up-regulation of integrin alpha-6 and integrin beta-1. The population of cancer stem cells, defined as ALDH positive cells, were increased in CDYL2-expressing MDA-MB-468 cells, showing that human CDYL2 is involved in proliferation of cancer stem cells. From these data, we conclude that, between self-renewal and differentiation of stem cells, mouse and human Cdyl2/CDYL2 is necessary for the implementation of the initial step of differentiation.
Citation Format: Naoko Hattori, Kana Kimura, Jumpei Taguchi, Toshio Imai, Yasuhiro Yamada, Toshikazu Ushijima. Cdyl2 is a chromodomain protein involved in the maintenance of pluripotency of stem cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 921. doi:10.1158/1538-7445.AM2017-921</jats:p
DMRT1を介した生体内での細胞初期化は全能性の特徴を持つヒト胚細胞腫瘍に類似したがんを形成する
No full text京都大学新制・課程博士博士(医科学)甲第23611号医科博第134号新制||医科||9(附属図書館)京都大学大学院医学研究科医科学専攻(主査)教授 遊佐 宏介, 教授 小川 誠司, 教授 山中 伸弥学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA
Effects of Parameters on the Setting Time of Fly Ash Based Geopolymers Using Taguchi Method
No full textAbstractGeopolymers are the inorganic polymer materials possessing properties superior than the properties of conventional materials. Geopolymers are also environment friendly materials. This paper determines the effects of parameters such as silica to alumina (Si/Al) ratio, sodium to alumina (Na/Al) ratio, water to solid (W/S) ratio, and temperature on the setting of fly ash geopolymers. The experiments were designed using Taguchi model. The setting time was determined by Vicat Needle apparatus. The Si/Al - 2.2, Na/Al - 1.4, W/S - 0.30, and temperature of 40 °C increased the setting time and workability of the geopolymers. The Si/Al ratio of 1.8, Na/Al ratio of 1.0, W/S ratio of 0.20, and temperature of 80° C caused fast setting of geopolymers. The setting time of geopolymers can be optimized using Taguchi method for particular applications
Apply Lean and Taguchi in Different Level of Variability of Food Flow Processing System
No full textAbstractHigh competition in food industry forced companies to increase their efficiency and reduce their waste. The author introduces model contain steps that help in reduce variability level in food flow processing system. As (Noorwali et al., 2012) mentioned steps which includes process mapping and simulation model for investigation types of variability in food processing system. This paper is continuing these steps using lean approach, Taguchi, simulation, and correlation. Lean will be use in categories seven types of wastes in food processing .Taguchi will use orthogonal array method for design the framework that applied in the simulation models. Correlation will be applied for identify which variable affecting more in food processing
Concise Synthesis of Potassium Acyltrifluoroborates from Aldehydes through Copper(I)-Catalyzed Borylation/Oxidation
No full textPotassium acyltrifluoroborates (KATs) were prepared through copper(I)-catalyzed borylation of aldehydes and subsequent oxidation. This synthetic route is characterized by the wide range of aldehydes accessible, favorable step economy, mild reaction conditions, and tolerance of various functional groups, and it enables the facile generation of a range of KATs, for example, bearing halide, sulfide, acetal, or ester moieties. Moreover, this method was applied to the three-step synthesis of various alpha -amino acid analogues that bear a KAT moiety on the C-terminus by using naturally occurring amino acids as the starting material
Metode Pcr-Topsis Untuk Optimasi Taguchi Multirespon (Studi Kasus Pada Proses Pembuatan Kertas)
No full textDalam bidang industri, statistika biasa digunakan dalam hal pengambilan
keputusan dalam suatu masalah, salah satu metode yang digunakan dalam
statistika untuk pengambilan keputusan adalah metode optimasi. Salah satu
metode optimasi yang sering dipakai adalah metode Taguchi, metode ini
diperkenalkan oleh Dr. Genichi Taguchi pada tahun 1940. Metode Taguchi
merupakan metode yang efisien digunakan dalam off line kontrol kualitas dimana
desain percobaan dikombinasikan dengan penurunan kualitas. Metode ini
mencakup tiga tahap desain yaitu desain sistem, desain parameter, dan desain
toleransi. Dalam dunia nyata jelas bahwa lebih dari satu karakteristik kualitas
harus dipertimbangkan untuk produk industri yang paling baik, yaitu dalam
sebagian besar aplikasi perhatian pelanggan adalah dengan masalah multirespon.
Namun demikian, metode Taguchi tidak tepat untuk mengoptimalkan masalah
multirespon karena teknik penilaian adalah prosedur optimasi utama dalam
metode Taguchi. Untuk mengatasi masalah ini, peneliti mengusulkan suatu
prosedur yang efektif disebut PCR-TOPSIS yang didasarkan pada kemampuan
proses ratio (PCR) teori dan teori preferensi order by kesamaan dengan solusi
ideal (TOPSIS) untuk mengoptimalkan masalah multirespon. Sehingga dengan
metode PCR-TOPSIS, kita dapat memperoleh solusi yang terbaik dan dapat
menghasilkan solusi yang memuaskan untuk masalah multirespon dalam proses
pembuatan kertas pada PT. Adiprima Suraprinta yang merupakan salah satu
perusahan manufaktur yang bergerak di bidang industri kertas khususnya daur
ulangan kertas.
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In industry, the statistics commonly used in decision-making in a problem, one of
the statistical methods used in decision-making is a method for optimization. One
of the optimization method that is often used is the Taguchi method, this method
was introduced by Dr. Genichi Taguchi in 1940 Taguchi method is an efficient
method used in off-line quality control in which the experimental design
combined with a decrease in quality. This method includes three stages, namely
the design of the system design, parameter design, and tolerance design. In the
real world it is clear that more than one quality characteristic must be considered
for the best industrial products, which in most applications is the customer's
attention to the problem multirespon. However, the Taguchi method is not
appropriate to optimize multirespon problem because valuation techniques are the
main optimization procedure in the Taguchi method. To overcome this problem,
the author proposes a procedure called PCR-TOPSIS effective based on process
capability ratio (PCR) theory and the theory of order preference by similarity to
ideal solution (TOPSIS) to optimize multirespon problem. So that the PCRTOPSIS
method, we can obtain the best solution and can produce satisfactory
solutions to problems multirespon in the papermaking process at PT. Adiprima
Suraprinta which is one of the manufacturing company engaged in the paper
industry, especially recycled paper replicates
[[alternative]]The Application of the Taguchi Mechods to the Optimum Process of the A390 Aluminum Alloy
No full text[[abstract]]The purpose of this research was to obtain the optimum process of the A390 Aluminum Alloy by Taguchi Methods. Effects of processing parameters, including the modification quantity of phosphorous, the temperature and holding time of solution treatment, the temperature of quenching water, the holding time of preaging and the temperature and holding time of artificial aging, on the machinability (tensile strength, hardness and wear resistance) promotion of the A390 Aluminum Alloy were investigated in this study.
The results indicated that optimum parameters of modification were 0.03% of phosphorous, solution treatment at 480℃ for 4 hours, quenching at 55℃, preaging for 24 hours and artificial aging at 150℃ for 3 hours could increase the tensile strength, hardness and wear resistance of the A390 Aluminum Alloy together. For results of robust design, solution treatment at 480℃ for 3 hours and quenching at 75℃ were modified and the other parameters didn't change. The adjustment might acquire robust tensile strength, but depressed hardness and wear resistance slightly. Modification of phosphorous and solution treatment were the most important parameters of the optimum process of the A390 Aluminum Alloy. The temperature and holding time of artificial aging were reduced with the modification of 0.03% phosphorous.
The above results of experiment can give the manufacturers for reference and hope this research is valuable to those who devote the improvement of product with Taguchi Methods.
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