249 research outputs found
The Flute Pedagogy of Raymond Guiot
No full textRaymond Guiot (b. 1930) is a representative of the Modern French Flute School, and a graduate of the class of legendary flutist Marcel Moyse (1889-1984) at the Paris Conservatoire in 1947. His prolific career, spanning from the early 1950s to the present day, includes not only his work as a highly respected classical performer and pedagogue, but also as a renowned popular musician, recording artist, and composer. Despite his long artistic and pedagogical career, his outstanding teaching work, developed in conservatories and institutions in France and Italy--and in workshops, masterclasses and summer academies around the world--and despite the large number of his students having developed successful artistic careers, Raymond Guiot is one of the least known premier French flute pedagogues at the international level. This research seeks to introduce this figure of the Modern French Flute School—the performer, the composer, and especially the pedagogue—to both the flute world and the larger music community. The author details, through her first-hand experience as a former student of Guiot and through a series of interviews with fellow former students and Guiot himself, the outstanding pedagogical principles of this musician. This study presents the influence of the ideas of Marcel Moyse and the Paris Conservatory traditions on his teaching, as well as the influence of his popular music experience, and also his own particular approach to interpretation and expression, general flute technique, and the development of an artistic personality. This document presents Guiot’s pedagogy and his contributions to the realm of the flute performance, including an account of his work as a performer and as a flute teacher, a genealogy of the Modern French Flute School, a catalogue of his compositions, and a list of his recordings
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
No full textOBJECTIVE: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. METHODS: EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study of patients treated with riociguat. Patients were followed for at least 1 year and up to 4 years from enrollment or until 30 days after stopping riociguat treatment. Primary safety outcomes were adverse events (AEs) and serious adverse events (SAEs) coded using Medical Dictionary for Regulatory Activities preferred terms and System Organ Classes version 21.0, collected during routine clinic visits and collated via case report forms. RESULTS: In total, 956 patients with CTEPH were included in the analysis. The most common AEs in these patients were peripheral edema/edema (11.7%), dizziness (7.5%), right ventricular (RV)/cardiac failure (7.7%), and pneumonia (5.0%). The most common SAEs were RV/cardiac failure (7.4%), pneumonia (4.1%), dyspnea (3.6%), and syncope (2.5%). Exposure-adjusted rates of hemoptysis/pulmonary hemorrhage and hypotension were low and comparable to those in the long-term extension study of riociguat (Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial [CHEST-2]). CONCLUSION: Data from EXPERT show that in patients with CTEPH, the safety of riociguat in routine practice was consistent with the known safety profile of the drug, and no new safety concerns were identified.sponsorship: The EXPERT registry was funded by Bayer AG (Berlin, Germany) and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Medical writing services provided by Richard Murphy PhD of Adelphi Communications Ltd, Macclesfield, UK were funded by Bayer AG in accordance with Good Publication Practice (GPP3) guidelines. (Bayer AG (Berlin, Germany), Merck Sharp Dohme Corp., Bayer AG)status: Publishe
Taxonomic, phylogenetic and functional diversity in the Mediterranean region : congruence or divergence?
No full textLes objectifs de la thèse sont d’analyser la biodiversité en région méditerranéenne européenne aux niveaux taxonomique, phylogénétique et fonctionnel et comprendre pourquoi ces différentes estimations de la biodiversité sont convergentes ou pas dans un contexte spatialisé et comment divers facteurs de l'environnement peuvent expliquer cette convergence ou son absence. Dans ce contexte, la thèse s’est d’abord focalisée sur la réalisation de nouveaux arbres phylogénétiques de la flore arborée méditerranéenne intégrant les espèces endémiques de cette région, permettant d’augmenter significativement la résolution des phylogénies en cours. Puis, à partir de cette phylogénie, il a été ensuite estimé les indices de diversité phylogénétique à différentes échelles (pays, îles, zones biogéographiques) pour les comparer à d’autres indices de la biodiversité (fonctionnelle et taxonomique) et pour étudier corrélativement l’impact de variables environnementales sur ces différents indices de biodiversitéThe objectives of the thesis are to analyze biodiversity in the European Mediterranean region at the taxonomic, phylogenetic and functional levels and understand why these different estimates of biodiversity are convergent or not in a spatialized context and how various environmental factors may explain this convergence or its absence.In this context, the thesis first focused on generating new phylogenetic trees of Mediterranean trees integrating the endemic species of this region, to increase significantly the resolution of current phylogenies. Then, using these phylogenies, indices of phylogenetic diversity were estimated at different scales (country, island, biogeographic zone) and compared with other indices of biodiversity (functional and taxonomic) and to correlatively study the impact of environmental variables on these different biodiversity indice
The solidification behaviour of the UO2–ThO2 system in a laser heating study
No full textThe high-temperature phase diagram of the UO2–ThO2 system has been experimentally revisited in the present study for the first time since 1970, using a laser heating approach combined with fast pyrometry in a thermal arrest method. The melting/solidification temperature, which is of fundamental information for a reactor design was studied here. It was found that low addition of ThO2 to UO2 would result in a slight decrease of the solidification temperature. A minimum was found at 3098 K around a composition of 5 mol% ThO2. The solid/liquid transition temperature was then observed to increase again with increasing ThO2 fraction. The literature value of pure ThO2 (around 3630 K) was well reproduced here. Important experimental difficulties, stemming from the high temperatures reached during the measurements, as well as a complete investigation with electron microscopy, Raman spectroscopy and powder X-ray diffraction, are extensively discussed. These results show the importance of the high-temperature oxygen chemistry in this actinide oxide compound.RST/Radiation, Science and TechnologyApplied Science
Editorial: Progressive fibrosing interstitial lung disease: from bench to bedside
No full textpeer reviewe
Laboratory data and broncho-alveolar lavage on Covid-19 patients with no intensive care unit admission: Correlation with chest CT features and clinical outcomes.
No full textpeer reviewedBroncho-alveolar lavage (BAL) is indicated in cases of uncertain diagnosis but high suspicion of Sars-Cov-2 infection allowing to collect material for microbiological culture to define the presence of coinfection or super-infection. This prospective study investigated the correlation between chest computed tomography (CT) findings, Covid-19 Reporting and Data System score, and clinical outcomes in Coronavirus disease 2019 (Covid-19) patients who underwent BAL with the aim of predicting outcomes such as lung coinfection, respiratory failure, and hospitalization length based on chest CT abnormalities. Study population included 34 patients (range 38-90 years old; 20 males, 14 females) with a positive nucleic acid amplification test for Covid-19 infection, suitable BAL examination, and good quality chest CT scan in the absence of lung cancer history. Pulmonary coinfections were found in 20.6% of patients, predominantly caused by bacteria. Specific correlations were found between right middle lobe involvement and pulmonary co-infections. Severe lung injury (PaO2/FiO2 ratio of 100-200) was associated with substantial involvement of right middle, right upper, and left lower lobes. No significant correlation was found between chest CT findings and inflammatory markers (C-reactive protein, procalcitonin) or hospitalization length of stay. Specific chest CT patterns, especially in right middle lobe, could serve as indicators for the presence of co-infections and disease severity in noncritically ill Covid-19 patients, aiding clinicians in timely interventions and personalized treatment strategies
First Mediterranean Assessment Report – Chapter 1: Introduction
No full textThe Chapter 1: Introduction of the First Mediterranean Assessment Report (MAR1) published by MedECC in November 2020 sets up the scope and objectives of the Assessment Report from What do we know about the Mediterranean Basin and what do we need to know? to the Principles and processes of work in MedECC.Preferred Citation: Lange MA, Llasat MC, Snoussi M, Graves A, Le Tellier J, Queralt A, Vagliasindi GM 2020 Introduction. In: Climate and Environmental Change in the Mediterranean Basin – Current Situation and Risks for the Future. First Mediterranean Assessment Report [Cramer W, Guiot J, Marini K (eds.)] Union for the Mediterranean, Plan Bleu, UNEP/MAP, Marseille, France, pp. 41-58, doi:10.5281/zenodo.7100592
Added Value of Dual-Energy CT in COVID-19 Pneumopathy.
No full textpeer reviewedTeaching point: The use of dual-energy instead of conventional single-energy computed tomography pulmonary angiogram can provide additional value concerning the diagnosis of COVID-19 and its complications, especially in the detection of small pulmonary embolism
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