1,721,078 research outputs found
Identification of predictive models including polymorphisms in cytokines genes and clinical variables associated with posttransplant complications after identical HLA-allogeneic stem cell transplantation
No full textBackgrounds: Although allogeneic hematopoietic stem cell transplantation
(allo-HSCT) is a potentially curative therapy for hematological malignancies, it
can be associated with relevant post-transplant complications. Several reports
have shown that polymorphisms in immune system genes are correlated with the
development of post-transplant complications. Within this context, this work
focuses on identifying novel polymorphisms in cytokine genes and developing
predictive models to anticipate the risk of developing GVHD, transplant-related
mortality (TRM), relapse and overall survival (OS).
Methods: Our group developed a 132-cytokine gene panel which was tested in
90 patients who underwent an HLA-identical sibling-donor allo-HSCT. Bayesian
logistic regression (BLR) models were used to select the most relevant variables.
Based on the cut-off points selected for each model, patients were classified as
being at high or low-risk for each of the post-transplant complications (aGVHD
II-IV, aGVHD III-IV, cGVHD, mod-sev cGVHD, TRM, relapse and OS).
Results: A total of 737 polymorphisms were selected from the custom panel
genes. Of these, 41 polymorphisms were included in the predictive models in 30
cytokine genes were selected (17 interleukins and 13 chemokines). Of these
polymorphisms, 5 (12.2%) were located in coding regions, and 36 (87.8%) in noncoding
regions. All models had a statistical significance of p<0.0001.
Conclusion: Overall, genomic polymorphisms in cytokine genes make it possible
to anticipate the development all complications studied following allo-HSCT
and, consequently, to optimize the clinical management of patients.The author(s) declare financial support was received for the
research, authorship, and/or publication of this article. This study
was partially supported by the Ministry of Economy and
Competitiveness ISCIII-FIS Grants PI14/01731 and PI17/01880,
PI20-00521, PID2021-123182OB-I00, and co-financed by the
European Regional Development Fund from the European
Commission, the “A way of making Europe” initiative, as well as
grants from Asociación Madrileña de Hematologı́a y Hemoterapia
(AMHH) and Sociedad Española de Hematologı́a y
Hemoterapia (SEHH)
Sosiaalipsykologian suunnannäyttäjistä apu aikuiskasvatuksen kriisiin?
No full textSosiaalipsykologian suunnannäyttäjiä, toim. Vilma Hänninen, Jukka Partanen ja Oili-Helena Ylijoki, Tampere (2001
Itäisen perhemallin jäljillä
Get PDFArvosteltu teos: Isän tuvasta omaan tupaan: Väestö ja kotitaloudet Karjalankannaksen maaseudulla 1750-1870 / Jukka Partanen. Helsinki, 2004
Monipuolista perhehistoriaa
Get PDFArvosteltu teos: Family life on the northwestern margins of imperial Russia, Tapio Hämynen, Jukka Partanen and Yury Shikalov (eds.), Joensuu (2004
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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