1,720,968 research outputs found
Complexation of adamantyl derivatives by a .beta.-cyclodextrin dimer
No full textThe binding constants, standard molar enthalpy, Gibbs free energy, and entropy changes were determined for the formation of complexes between adamantyl derivatives and a β-cyclodextrin dimer. It is concluded that, within experimental error, the two cyclodextrin residues in the dimer behave independent to each other when complexing the adamantyl derivatives
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Design of dialkyl surfactants from nitrilotriacetic acid as head group
No full textNew double-chain surfactants can be designed in which nitrilotriacetic acid plays the role of glycerol in phospholipids. The synthetic methodology is applied to the synthesis of (2-(bis(2-dodecylamino)-2-oxoethyl)amino)acetic acid. This is a symmetric dimeric surfactant but the methodology allows the synthesis of asymmetric double-chain surfactants as well. The Krafft temperature is 16-18 °C. The critical aggregation concentration of the new surfactant (4.76 × 10-5 mol dm-3 in NaOH 0.01 M and 25 °C; surface tension measurements) is two hundred times lower than that for sodium 2-dodecanamidoacetate, which can be considered its monoalkyl surfactant analog, indicating the enhanced surfactant properties resulting from the presence of two hydrophobic alkyl chains. The shape of the aggregates was investigated by transmission electron microscopy. At 40 °C, the main structure present in solution corresponds to vesicles and, from the size distribution of their radii, values of (0.34 ± 0.06)kT and 56.7 ± 2.6 nm were obtained for the effective bending elasticity constant and the spontaneous radius of curvature of vesicles, respectively. © The Royal Society of Chemistry 2014
Ice-like encapsulated water by two cholic acid moieties
No full textStarting from the structure of ice (in which each water molecule is surrounded by other four water molecules forming a tetrahedron with a value of 4.51 A for the edge O-O distance), and the knowledge that this value also corresponds to the O7-O12 distance of the skeleton of cholic acid, it is hypothesized that two steroid cholic acid moieties, with an appropriate steroid-steroid distance and a belly-to-belly orientation, could encapsulate a single water molecule between them. To check this hypothesis two succinyl derivatives of cholic acid (a monomer and the related head-head dimer in which the succinyl group is the linking bridge) were designed. The expected "ice-like" structure is found in the crystal of the dimer. There is a hydrogen bond synergy between those participating in the "ice-like" structure, and those in which the bridge is involved with the O7-H hydroxy group and the side chain of the steroid. (c) 2012 Elsevier Inc. All rights reserved
Aggregation Behavior of Tetracarboxylic Surfactants Derived from Cholic and Deoxycholic Acids and Ethylenediaminetetraacetic Acid
No full textThe reaction of 3 beta-aminoderivatives of cholic and deoxycholic acids (steroid residues) with dimethyl ester of ethylenediaminetetraacetic acid (bridge) leads to the formation of dimers carrying four carboxylic organic function,, two of them located on the side chain of each steroid residue and the other two on the bridge. As tetrasodium stilts. these new compounds behave as surfactants and have been characterized by surface tension. fluorescence intensity of pyrene (as a probe), and static and dynamic light scattering measurements. Thermodynamic parameters for micellization were obtained from the dependence of the critical micelle concentration (cmc) with temperature. For both surfactants. the fraction of bound counterions is close to 0.5. The aggregation behavior is similar to one of their bile salt residues [i.e., sodium cholate (NaC) and sodium deoxycholate (NaDC)] and can be Summarized its follows: (i) molecular areas at the interface for the new surfactants are fairly close to twice the value for a single molecule in a monolayer of natural bile salts; (ii) the environment where pyrene is solubilized is very apolar, as in natural bile salt aggregates; (iii) Gibbs free energies (per steroid residue) for micellization are not far from published values for NaC and NaDC, and the differences can e understood on the basis of less hydrophobicity of the new surfactants due to the charges in the bridge: and (iv) as for NaC and NaDC. aggregates have rather low aggregation numbers (which depend oil the amount of added inert salt, NaCl). A structure based oil the disklike model accepted for small bile salt aggregates is proposed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Complexation of 3.alpha.,7.alpha.,12.alpha.-trihydroxy-5.beta.-cholan-24-amine by .beta.- and .gamma.-cyclodextrins
No full textThe binding constants, standard molar enthalpy, Gibbs free energy, and entropy changes were determined for the formation of inclusion complexes between 3α,7α,12α-
trihydroxy-5β-cholan-24-amine, C24NH2, and β-cyclodextrin and γ-cyclodextrin. The stoichiometry of both complexes is 1:1 in agreement with previously reported results for other trihydroxy bile salts. The equilibrium constant values for the formation of the inclusion complex are similar as well. The structure of the C24NH2/γ-cyclodextrin complex was studied by ROESY experiments. These results suggest that B, C and D-rings of the steroid skeleton, as well as the side chain, interact with the cyclodextrin cavity, while the A ring of the steroid nucleus remains outside the cavity
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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