50,059 research outputs found
Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions
No full textSummaryAge can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging—reduced endocytosis and protein aggregation—are interconnected and regulated by Vac17
1968:1
No full textARTIKLAR
Ruben Josefson: Vad betyder Luther i dag?
Anders Nygren: »Framåt till Luther». Till frågan om Lutherska Världsförbundets andliga profil
J. G. M. Willebrands: Reformationen och vår tid
Vilmos Vajta: Reformationen – idag
Ragnar Holte: Kan moralen påverkas av fakta?
TEOLOGISK LITTERATUR
Lars Hartman: Prophecy interpreted. The formation of some Jewish apocalyptic texts and of the eschatological discourse Mark. Anm. av Per Block
S. Serenius: Liturgia svecanae ecclesiae catholicae et orthodoxae conjormis. En liturgihistorisk undersökning med särskild hänsyn till struktur och förlagor. Anm. av Roland Persson
FRÅN DEN TEOLOGISKA SAMTIDEN
Per Erik Persson: Reformationsminnet
Harry Aronson: Baltisk konferens i Lund 5–8 juni 196
Analyse av erfaringsbasert prosjektledelse i entreprenørbransjen: En casestudie av et byggeprosjekt sett i lys av teoretiske rammeverk
No full textFormålet med denne studien har vært å undersøke hvordan erfaringsbaserte prosjektledere arbeider i praksis, og hvordan deres arbeidsform samsvarer med prinsippene i PRINCE2. Studien er gjennomført som en kvalitativ casestudie av byggeprosjektet Ny Sikkerhets-psykiatri (NSP), basert på dokumentanalyse og semistrukturerte intervjuer med sentrale roller i prosjektorganisasjonen.
Analysen viser at prosjektlederne styrer tett på produksjonen, med vekt på tilstedeværelse, fleksibilitet, samarbeid og praktisk dømmekraft. Spesielt planlegging, kvalitet og organisering ivaretas godt gjennom en kombinasjon av visuelle verktøy, tett oppfølging og sterkt eierskap til både fag og leveranser. Dette ser ikke bare ut til å skyldes struktur og prosesser, men også meningskapning og taus kunnskap. En prosjektkultur preget av tillit, tilstedeværelse og felles situasjonsforståelse spiller en sentral rolle i å opprettholde styring og samhandling.
Sammenlignet med PRINCE2 fremkommer det at flere av rammeverkets prinsipper og styringstemaer er til stede i praksis, selv om PRINCE2 ikke benyttes eksplisitt. Eksempelvis ivaretas løpende forretningsmessig begrunnelse og delegering av ansvar, men i mer uformelle og erfaringsbaserte former.
Studien konkluderer med at erfaringsbasert prosjektledelse kan gi høy styringsevne i komplekse prosjekter, men at svak dokumentasjon og høy personavhengighet kan svekke sporbarhet og overførbarhet. Det pekes på et behov for prosjektstyringsrammeverk som i større grad fanger opp praksisens dynamikk og relasjonelle dimensjoner, og en økt bevissthet for dokumentasjon i bransjen
Author Self-Citation in the Turkish Otorhinolaryngology Literature
No full textObjective:To evaluate the prevalence and other characteristics of author self-citations in six Turkey-originated general otorhinolaryngology (ORL) journals of Turkish ORL literature.Methods:A total of 970 articles published in six Turkey-originated general ORL journals (ENT Updates, Journal of Ear Nose Throat and Head Neck Surgery, KBB-Forum, Praxis of Otorhinolaryngology, The Turkish Journal of Ear Nose and Throat, and Turkish Archives of Otorhinolaryngology) in 2016-2020 were analyzed for author self-citations. The association between author self-citations and journal types, study types, study topics, country of origin, and compatibility with the topic were also evaluated.Results:There were 265 author self-citations (0.273 per article) which corresponded to 1.36% of all citations. There was no significant difference between the journal types, study topics, and origin of the studies in terms of mean self-citation values per study, whereas case reports had significantly lower self-citations than review and original investigations. There were three citations (1.1%) that were irrelevant to the study topic.Conclusion:To the best of our knowledge, this is the first study that investigated the practice of author self-citation in Turkish ORL literature. Author self-citation rate in the Turkish-originated general ORL journals was found remarkably lower than the medical literature, whereas the self-citations were found compatible with the study topic to a very large extent. Members of the scientific community including authors, readers, and journal editors should be cautious regarding the unethical practices of self-citations
Applicativo web per audioguide - HooRMI Author
No full textHooRMI Author è la parte da content creator del progetto HooRMI.
La dissertazione si concentra sul funzionamento HooRMI Author, ovvero di come viene permesso all'utente di produrre contenuti video basati sulla propria posizione acquisita tramite tecnologia Plus code e caricarli sul proprio canale Youtube. I contenuti risulteranno pronti per essere selezionati e fruiti dai turisti, grazie alla profonda personalizzazione dei metadati associati ad ogni clip
Sectoral allocation by gender of Latin American workers over the liberalization period of the 1990s
No full textThe recent restructuring of Latin American economies has renewed interest in the effects of trade liberalization, on labor markets, and on the gender division of labor. The author does not attempt to establish casuality between economic reforms, and the types of jobs that men and women hold. Instead, she provides a detailed description of the trends in male, and female formal, and informal sector participation during the economic reform period in Argentina, Brazil, and Costa Rica. The author first compares the gender composition of the formal, informal wage, and self-employment sectors in a year before reforms (1988 for Argentina, 1989 for Brazil, and Costa Rica), and a year after reforms implementation (1997 for Argentina, 1995 for Brazil and Costa Rica). Although women continued to be more likely than men to work in the informal wage sector, there is no trend of"masculinization"or"feminization"of the informal sector, or any other. Instead, in Argentina men have overtaken women as the most prevalent workers in the informal wage sector, while in Brazil, the opposite has occurred (as men move into self-employment). In Costa Rica there have been no statistical, observable changes. The author then considers the distribution across sectors within each gender group, to identify whether men, and women are more likely to select different sectors in the post-reform period relative to the pre-reform period. Among both men, and women in all three countries (except Brazilian men), workers have become more likely to hold informal wage jobs, and less likely to hold formal sector jobs. Trends in human capital accumulation explain these changes for both men, and women, while changes in gender roles, primarily in homecare and marriage, do not seem to have an effect.Health Monitoring&Evaluation,Labor Policies,Population&Development,Public Health Promotion,Environmental Economics&Policies,Health Monitoring&Evaluation,Environmental Economics&Policies,Population&Development,Banks&Banking Reform,Work&Working Conditions
Number of 3-grams per author (in thousands).
No full textNumber of 3-grams per author (in thousands).</p
Production, productivity per author and per age group of authors of new Siluriformes species descriptions.
No full text<p>Production, black columns, y1 axis; Productivity per author, grey columns, y2 axis; Productivity per age group, striped columns, y2 axis.</p
The dynamics of unreliable narration:Implicit and omitted authors, double narratees and constructive readers in first person unreliable narration
No full textPer Krogh Hansen brings attention to one of the most discussed narratological concepts in recent years, the ‘unreliable narrator’. In the article »The Dynamics of Unreliable Narration«, Hansen is considering to what extent the question of authorial control or intention is relevant when analysing and interpreting unreliable narrators. In the first part of the article, he questions this claimed essentiality of an authorial agent from three different angles: One concerning the border between diegetic and extradiegetic issues. Another with specific focus on unreliable simultaneous narration (first person, present tense). And a third with attention paid to the role of unreliable narrators in factual narratives. In the article, he proposes a model for describing the different dynamic roles the authorial agent, as well as the empirical reader, plays in different forms of unreliable narration. Here, terms like ‘implicit author’, ‘omitted author’, ‘double narratees’ and ‘constructive readers’ are introduced andillustrated by examples of Dennis Cooper and Edgar Allan Poe
Average per-author h-index vs Average REF Impact Score.
No full textAverage per-author h-index vs Average REF Impact Score.</p
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