1,786,920 research outputs found
Park-Sung-Joon/GLMGE: GLMGE
No full text<p>A computational method for modeling the spatial proximal and distal regulatory interactions. Our method combined regression-based models to identify key regulators through gene expression prediction and a graph-embedding approach to detect coregulated genes.</p>
The False Dichotomy of South Korean Economic Theories: An Interview with Hyeng-Joon Park
No full textIn his new book, "Chaebol: The Transnational Capital That Rules Korea," Hyung-Joon Park argues that the state has not receded, but has become more of an agent for capital – an interview with Seon-hee Ahn
Young Joon Park
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2014. 8MasterBackground and objectives: Beta 2 integrins (CD11/CD18) are cell adhesion molecules that play a major role in cell migration to inflammatory sites. They also induce cellular signaling, subsequently leading to cytokine production. On our preliminary strudy, we demonstrated possible alteration in susceptibility to Behcet’s disease (BD) according to single nucleotide polymorphisms of CD11a, CD11c and CD18. Thus, our aim was to investigate the possible relationship between beta 2 integrins expression and BD.
Materials and methods: BD patients (n=51) consisting of 22 active patients and 29 inactive patients, 20 recurrent aphthous ulcer (RAU) patients and 23 healthy controls (HC) were included. The expression of CD11a, CD11b, CD11c, as well as CD4, CD8, CD18 and CD56 in peripheral blood mononuclear cells was assessed by flow cytometry. The transcriptional level expression of CD11a and CD11c was assessed by reverse transcription polymerase charin reaction. Western blot analysis was performed to evaluate CD11a and CD11c protein. Immunohistochemical analysis of CD11a and CD11c was done on erythema nodosum like lesions of 13 BD patients and 14 idiopathic erythema nodosum lesions.
Results: On flow cytometry, the surface expression of CD3 was significantly increased whereas CD4 expression was significantly decreased in BD patients. Expression of CD11a was significanty increased, in contrast to decreased expression of CD11b. RAU patients showed significant decrease in mRNA level of CD11a whereas BD patients did not, compared to the HC. CD11c expression was significantly higher in active BD group compared to the inactive group. CD11c mRNA expression was decreased in BD patients but showed increased CD11c expression by Western blotting compared to the healthy controls. Immunohistochemisty did not show any significant difference between BD patients and classical erythema nosodum.
Discussion: In contrast to previous reports, our study showed decreased CD11a surface expression on peripheral blood. The decrease is likely to have caused from active transmigration of CD11a+ cells in to the tissues, as relative mRNA level and western blot results suggest. CD11c did not show significant difference of surface expression among other groups except the active and the inactive group. Based on the relative low mRNA expression and higher expression in western blot, we suggest that the CD11c might have an immunomodulatory role.
Conclusion: Thus, our study implies that the differential expression of beta 2 integrins in BD patients, especially CD11a and CD11c is likely to be involved in the pathogenesis of BD. Further studies on the functional effect of CD11/CD18 in immunologic abnormalities are needed to elucidate the exact role of CD11/CD18 in B
Joon Shim Interview for Veterans\u27 Voices Project
No full textJoon K. Shim was commissioned into the United States Army in February 2002. Until 2006 Ms. Shim was earning an M. D. at George Washington University and University of Massachusetts. Upon becoming a general surgeon she served two tours in Afghanistan as a combat trauma surgeon during Operation Enduring Freedom. In 2015 she left the Army with the rank of Colonel.https://corescholar.libraries.wright.edu/veterans_voices/1150/thumbnail.jp
Bong Joon-ho’s audiovisual suspense
No full textDen här studien undersöker hur den sydkoreanske filmskaparen Bong Joon-ho använder sig av olika audiovisuella tecken för att skapa spänning i sina thrillerfilmer. Syftet med uppsatsen är att få en större förståelse för fenomenet spänning och hur det skapas. Genomen semiotisk och multimodal filmanalys av totalt nio utvalda scener från Memories of Murder (2003), Mother (2009) och Parasite (2019) utforskar studien Bong Joon-hos filmskapande och hur han både skapar och bibehåller spänning. Undersökningens resultat pekar på att Bong Joon-ho använder audiovisuella tecken för att skapa konnotationer och betydelser som bygger upp spänningen. Han gör det genom att göra aktiva val av olika semiotiska resurser som miljö, objekt, kamerarörelse, bildutsnitt, kameravinklar, klippning, rytm, ljud och musik. Slutligen visar undersökningen hur spänningsskapande är komplext och kräver att filmskaparen gör noggranna val baserat på filmens innehåll och kontext.
Bong Joon-ho’s audiovisual suspense
No full textDen här studien undersöker hur den sydkoreanske filmskaparen Bong Joon-ho använder sig av olika audiovisuella tecken för att skapa spänning i sina thrillerfilmer. Syftet med uppsatsen är att få en större förståelse för fenomenet spänning och hur det skapas. Genomen semiotisk och multimodal filmanalys av totalt nio utvalda scener från Memories of Murder (2003), Mother (2009) och Parasite (2019) utforskar studien Bong Joon-hos filmskapande och hur han både skapar och bibehåller spänning. Undersökningens resultat pekar på att Bong Joon-ho använder audiovisuella tecken för att skapa konnotationer och betydelser som bygger upp spänningen. Han gör det genom att göra aktiva val av olika semiotiska resurser som miljö, objekt, kamerarörelse, bildutsnitt, kameravinklar, klippning, rytm, ljud och musik. Slutligen visar undersökningen hur spänningsskapande är komplext och kräver att filmskaparen gör noggranna val baserat på filmens innehåll och kontext.
Park-Sung-Joon/ATACprofWS: ATACprofWS: ATAC-seq Profiler with Spike-in
No full textATAC-seq Profiler with Spike-i
Park-Sung-Joon/ATACprofWS: ATACprofWS: ATAC-seq Profiler with Spike-in
No full textATAC-seq Profiler with Spike-i
Bong Joon-ho, o dell'efferatezza inesorabile
No full textProfilo storico-critico del regista coreano Bong Joon-h
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