34 research outputs found
Images of Sacrifice: Religion, Power, and Colonial Ambition in the Americas
No full textThe article addresses images of sacrifice from Mesoamerica and the adoption of this imagery during Protestant colonization as a way to limit the Spanish power. The author posits that while initially serving the purpose of demonizing the Spanish Catholic presence in the Americas, the use of this imagery led Protestant powers to assert claims of religious and political superiority over both the Spanish and the indigenous peoples
Images of Sacrifice: Religion, Power, and Colonial Ambition in the Americas
No full textThe article addresses images of sacrifice from Mesoamerica and the adoption of this imagery during Protestant colonization as a way to limit the Spanish power. The author posits that while initially serving the purpose of demonizing the Spanish Catholic presence in the Americas, the use of this imagery led Protestant powers to assert claims of religious and political superiority over both the Spanish and the indigenous peoples
CORPORATIONS-THE FAIR AND EQUITABLE TEST IN RECAPITALIZATIONS
No full textChanges in capital structures of corporations which modify rights of security holders generally occur under one of two circumstances: (1) reorganization of insolvent corporations which affects the rights of creditors as well as shareholders and necessitates judicial supervision; and (2) recapitalization of solvent corporations involving only the relative rights of the different classes of shareholders. It is the author\u27s present purpose to focus attention on the effect of the latter type of modification on the most zealously guarded right of the preferred shareholder--the right to accrued dividends on cumulative preferred stock
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CORPORATIONS-THE FAIR AND EQUITABLE TEST IN RECAPITALIZATIONS
No full textChanges in capital structures of corporations which modify rights of security holders generally occur under one of two circumstances: (1) reorganization of insolvent corporations which affects the rights of creditors as well as shareholders and necessitates judicial supervision; and (2) recapitalization of solvent corporations involving only the relative rights of the different classes of shareholders. It is the author\u27s present purpose to focus attention on the effect of the latter type of modification on the most zealously guarded right of the preferred shareholder--the right to accrued dividends on cumulative preferred stock
Marinaleda – ¿en utopi?
No full textFollowing paper focuses on Marinaleda, an Andalusian village led by the charismatic mayor Juan Manuel Sánchez Gordillo, with the purpose of analyzing whether or not the project Marinaleda is fulfilling his expectations for the village as a ‘socialist utopia’ and its survival. A fieldtrip to the village made it possible to conduct interviews with the residents, and enhanced an understanding of the structure of the village, but more importantly their mayor. Historical events will be treated in the paper for a further understanding of the context in which the village came to be. In addition to this, the paper is based upon a novel called The Village Against The World, by the English journalist and author Dan Hancox. The structure of the village, the incentives of the mayor regarding the realization of the ’socialist utopia’ and possible conflicts will be discussed, from our but also Hancox’s partly opposing point of view. In conclusion, the project partly succeeds its expectations but the survival is uncertain.Following paper focuses on Marinaleda, an Andalusian village led by the charismatic mayor Juan Manuel Sánchez Gordillo, with the purpose of analyzing whether or not the project Marinaleda is fulfilling his expectations for the village as a ‘socialist utopia’ and its survival. A fieldtrip to the village made it possible to conduct interviews with the residents, and enhanced an understanding of the structure of the village, but more importantly their mayor. Historical events will be treated in the paper for a further understanding of the context in which the village came to be. In addition to this, the paper is based upon a novel called The Village Against The World, by the English journalist and author Dan Hancox. The structure of the village, the incentives of the mayor regarding the realization of the ’socialist utopia’ and possible conflicts will be discussed, from our but also Hancox’s partly opposing point of view. In conclusion, the project partly succeeds its expectations but the survival is uncertain
Generic accelerated sequence alignment in SeqAn using vectorization and multi-threading
No full textMotivation
Pairwise sequence alignment is undoubtedly a central tool in many bioinformatics analyses. In this paper, we present a generically accelerated module for pairwise sequence lignments applicable for a broad range of applications. In our module, we unified the standard dynamic programming kernel used for pairwise sequence alignments and extended it with a generalized inter-sequence vectorization layout, such that many alignments can be computed simultaneously by exploiting SIMD (Single Instruction Multiple Data) instructions of modern processors. We then extended the module by adding two layers of thread-level parallelization, where we a) distribute many independent alignments on multiple threads and b) inherently parallelize a single alignment computation using a work stealing approach producing a dynamic wavefront progressing along the minor diagonal.
Results
We evaluated our alignment vectorization and parallelization on different processors, including the newest Intel® Xeon® (Skylake) and Intel® Xeon Phi™ (KNL) processors, and use cases. The instruction set AVX512-BW (Byte and Word), available on Skylake processors, can genuinely improve the performance of vectorized alignments. We could run single alignments 1600 times faster on the Xeon Phi™ and 1400 times faster on the Xeon® than executing them with our previous sequential alignment module.
Availability
The module is programmed in C++ using the SeqAn (Reinert et al., 2017) library and distributed with version 2.4. under the BSD license. We support SSE4, AVX2, AVX512 instructions and included UME::SIMD, a SIMD-instruction wrapper library, to extend our module for further instruction sets. We thoroughly test all alignment components with all major C++ compilers on various platforms
The evaluation of the Hancox "Workbook to develop the ability to detect bias: a study in connotation"
No full textThesis (M.A.)--Boston University. PLEASE NOTE: Missing pages 33, 35, 37, 41-43, 48, 71.PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.2999-01-0
VEGF activates receptor-operated cation channels in human microvascular endothelial cells
No full textRole: Joint senior/corresponding author (co-wrote grant and paper; all electrophysiology conducted in my laboratory). Importance: First characterisation of the ion channels mediating cation entry into human microvascular endothelial cells in response to Vascular Endothelial Growth Factor (VEGF). Shows channels to have TRP-like characteristics and that VEGF activates recombinant TRPC3/C6 channels.Role: Joint senior/corresponding author (co-wrote grant and paper; all electrophysiology conducted in my laboratory). Importance: First characterisation of the ion channels mediating cation entry into human microvascular endothelial cells in response to Vascular Endothelial Growth Factor (VEGF). Shows channels to have TRP-like characteristics and that VEGF activates recombinant TRPC3/C6 channels
Proarrhythmia in KCNJ2-linked short QT syndrome: Insights from modelling
No full textAims: One form of the short QT syndrome (SQT3) has been linked to the D172N gain-in-function mutation to Kir2.1, which preferentially increases outward current through channels responsible for inward rectifier K current (IK1). This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias. Methods and results: The ten Tusscher et al. model for human ventricular action potentials (APs) was modified to incorporate changes to IK1 based on experimentally observed changes to Kir2.1 function: both heterozygous (WT-D172N) and homozygous (D172N) mutant scenarios were studied. Cell models were incorporated into heterogeneous one-dimensional (1D), 2D tissue, and 3D models to compute the restitution curves of AP duration (APD-R), effective refractory period (ERP-R), and conduction velocity (CV). Temporal and spatial vulnerability of ventricular tissue to re-entry was measured and dynamic behaviour of re-entrant excitation waves (lifespan and dominant frequency) in 2D and 3D models of the human ventricle was characterized. D172N 'mutant' IK1 led to abbreviated APD and ERP, as well as steeper APD-R and ERP-R curves. It reduced tissue excitability at low excitation rates but increased it at high rates. It increased tissue temporal vulnerability for initiating re-entry, but reduced the minimal substrate size necessary to sustain re-entry. SQT3 'mutant' IK1 also stabilized and accelerated re-entrant excitation waves, leading to sustained rapid re-entry. Conclusion: Increased IK1 due to the Kir2.1 D172N mutation increases arrhythmia risk due to increased tissue vulnerability, shortened ERP, and altered excitability, which in combination facilitate initiation and maintenance of re-entrant circuits. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2012
To identify and analyse how income and population is impacting on Generation X consumers shopping experience in retailing. And to investigate how retailers/brands are responding to the trends (identified above) which are impacting on Generation X consumers
No full textThe purpose of this assignment is to investigate how income and population are impacting on Generation X consumers. The literature review will demonstrate how income has had a negative effect on the consumer and how population has had a positive effect. It will also show how retailers have reacted to these changes.
From the reading of the literature review it will be become apparent that consumer’s income has decreased as a result of the recession. It will also be clear that they have made changes by purchasing own brands, show rooming and online shopping. Increasing population have led to increased prices changes that now consumers have a wider variety of products, an emphasis on healthier products and increasing population can lead to increased prices.
From the retailers point of view they have made many changes in order to keep up with the change in population and income. Some of these reactions include: the increase in technology, the introduction of own brands which entices the price conscious consumer, the enhancement of loyalty cards which feel will increase brand loyalty and finally the opening of new stores due to the increase in population.
It was found that the respondents had similar feelings to what was stated in the Literature Review. The consumers all felt they had suffered a decrease in income, leading them to be price conscious, since the beginning of the recession. The view of own brand products was overall positive, which is in line with the literature review.
Each respondent showed to some degree an interest in becoming healthier. It was also stated that they felt there was an increase in population, which has led to more variety of products available. In difference to the literature review the respondents didn’t respond as well to technology as was expected. The use of loyalty cards has increased with respondents stating they made life easier. This was followed up by the use of sales promotions which were greatly appreciated by the budget conscious consumer. Author keywords: Generation X, ethnography, marketing research, consumers, income, population, retai
