681 research outputs found
Streptococcus pneumoniae carriage. The impact of intranasal vaccination and mucosal immunity
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169261.pdf (Publisher’s version ) (Open Access)Radboud University, 29 mei 2017Promotor : Groot, R. de Co-promotor : Jonge, M.I. d
Immunity against RSV infections: Monocytes and interferon beta as regulators of the immuneresponse in newborns and infants
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181327.pdf (Publisher’s version ) (Open Access)Radboud University, 26 januari 2018Promotor : Groot, R. de Co-promotores : Ferwerda, J.G., Jonge, M.I. d
Differential pathogen-host interactions
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207783.pdf (Publisher’s version ) (Open Access)Radboud University, 25 oktober 2019Promotor : Pickkers, P. Co-promotores : Kox, M., Jonge, M.I. d
Nucleic acid-based diagnostics for viral respiratory tract infections in children
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165627.pdf (Publisher’s version ) (Open Access)Radboud University, 01 februari 2017Promotores : Groot, R. de, Hermans, P.W.M. Co-promotor : Jonge, M.I. d
Determinants of disease severity in children with viral lower respiratory tract infections
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166986.pdf (Publisher’s version ) (Open Access)Radboud University, 30 maart 2017Promotores : Groot, R. de, Hermans, P.W.M. Co-promotores : Ferwerda, J.G., Jonge, M.I. d
Mucosal Immunity and the Role of Epithelial Cells in Orchestrating Respiratory Pathogen Defence
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319748.pdf (Publisher’s version ) (Closed access)Respiratory infections pose a significant global health burden. Our research focused on how the immune system, particularly the epithelium—the layer of cells that first comes into contact with everything we inhale—protects the airways against pathogens. We studied immune responses through population studies and laboratory models. The results show that immune responses in the airways vary based on age, season, sex, BMI, smoking, and respiratory symptoms. Additionally, epithelial immune responses differed depending on their location in the airways and the type of pathogen. The epithelial response was even specific to different variants of the same pathogen. These insights may contribute to improved treatments, vaccinations, and diagnostics. Our research highlights the crucial role of epithelial cells in airway immunity and helps explain why some individuals are more susceptible to respiratory infections than others.Radboud University, 20 juni 2025Promotor : Jonge, M.I. de Co-promotor : Hartog, G. den128 p
Decoding mucosal immunity: Impact of SARS-CoV-2 and Bordetella pertussis vaccination and infection
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319744.pdf (Publisher’s version ) (Open Access)To prevent illness and death from infections, vaccinations are crucial. Vaccinations, like natural infections, activate the adaptive immune system and create immunological memory. Most vaccines are administered via injections (intramuscularly) and primarily stimulate immunity in the blood, mainly IgG antibodies. While this is effective against severe illness, vaccinations sometimes provide insufficient protection against mild symptoms and the spread of pathogens through the mucous membranes. This is seen with pathogens like SARS-CoV-2 and B. pertussis. Individuals vaccinated against these pathogens can still become infected and spread the infection.
In this dissertation we investigate how infection and vaccination affect the antibody response in the upper respiratory tract. By comparing the antibody response to infection and vaccination, we can better understand how to improve protection against respiratory infections, not only against severe illness but also against spread. This is important for the development of better vaccines.Radboud University, 19 juni 2025Promotores : Jonge, M.I. de, Huijnen, M.A. Co-promotor : Diavatopoulos, D.A.205 p
Respiratory syncytial virus infections: how antibodies and bacteria modulate innate immunity and disease severity
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157668.pdf (Publisher’s version ) (Open Access)Respiratory syncytial virus (RSV) can cause severe respiratory tract infections in young children. It is largely unknown why some children will develop very severe infections by RSV, whereas the majority will only get a common cold. In this doctoral thesis, we studied whether maternal antibodies and bacteria that are present in the nose have an influence on severity of disease.
Antibodies do not only reduce infection, but may also simultaneously enhance the inflammatory response. We found that the amount of antibodies in the nose, as compared to antibodies in the blood, correlates better with viral load and inflammation.
We also studied the role of bacterial colonization in RSV infected children and found that presence of specific bacteria may enhance the inflammatory response, whereas other bacteria are able to reduce infection.
Further insight in the role of antibodies and colonizing bacteria may help to develop more effective preventive strategies.RU Radboud Universiteit, 23 juni 2016Promotores : de Groot, R., Hermans, P.W.M. Co-promotores : Ferwerda, J.G., Jonge, M.I. d
Government influence and foreign direct investment: Organizational learning in an electronics cluster
No full textThis article demonstrates government and foreign direct investment in influencing the formation and development of the electronics cluster in Guadalajara, Mexico. The organizational limitations and the lack of planning in the technological learning process aside, the triple helix paradigm has become critical in upgrading the electronics industry in Guadalajara. The study analyzes technology transfer and its adaptation through technical and research cooperation within national and international innovation systems. It also examines the role of multinational corporations within the triple helix model, and how they impact upon the formation, growth and development of an electronics cluster in Guadalajara. © The Author(s), 2010
Grain-size effects on gas response in nanostructured Gd0.9Ba0.1CoO3
No full textThis article demonstrates government and foreign direct investment in influencing the formation and development of the electronics cluster in Guadalajara, Mexico. The organizational limitations and the lack of planning in the technological learning process aside, the triple helix paradigm has become critical in upgrading the electronics industry in Guadalajara. The study analyzes technology transfer and its adaptation through technical and research cooperation within national and international innovation systems. It also examines the role of multinational corporations within the triple helix model, and how they impact upon the formation, growth and development of an electronics cluster in Guadalajara. " The Author(s), 2010.",,,,,,"10.1177/0896920510365922",,,"http://hdl.handle.net/20.500.12104/41788","http://www.scopus.com/inward/record.url?eid=2-s2.0-77954306377&partnerID=40&md5=114f747a527332e8c4b5ed54213a2f81",,,,,,"4",,"Critical Sociology",,"53
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