1,721,008 research outputs found
O.W. Jones, Isaac Williams and his Circle, London, S.P.C.K., 1971
No full textNédoncelle Maurice. O.W. Jones, Isaac Williams and his Circle, London, S.P.C.K., 1971. In: Revue d'histoire et de philosophie religieuses, 52e année n°2,1972. pp. 240-242
Microfluidic systems for identification of antimicrobial-resistant pathogens
No full textAntimicrobial resistance (AMR) poses a critical, yet historically understated threat to global public health. Recent mutations in the enterobacteriaceae genome that confer resistance to multiple antibiotics, have made some virtually untreatable.Currently, antibiotics are prescribed largely on guesswork, with little or no prior evidence as to their efficacy. This not only accelerates the spread of AMR, but endangers patient's lives in the process. To counter this, new tools are required which can rapidly identify a pathogen's susceptibility to an antibiotic prior to administration. Traditional procedures are labour-intensive, taking several days - with sample preparation and cell-culture being the primary bottlenecks.A novel, proof-of concept system was developed to rapidly determine antibiotic resistance in pathogens using nucleic acid analysis. The system comprised of a plastic microfluidic cartridge, control software, optical reader and *control hardware*.E. coli were captured, concentrated and lysed within the device; DNA could be amplified on-chip using rapid, isothermal DNA amplification (Recombinase Polymerase Amplification). The assay identified samples containing the CTX-M resistance gene; the limit of detection was 500 copies (in 50l), as measured by the reader's integrated fluorescence microscope.Each component was validated prior to integration into the final system. Concentrations of E. coli equivalent to a urinary-tract-infection (100,000 Colony Forming Units/ mL) were captured with up to 98% efficiency from 1ml suspensions onto functionalised, 0.5m magnetic, ion-exchange beads. These were isolated on-chip by a NdFeB magnet, providing up to 96% bead-capture and a 100x volume reduction. An oil compartmentalised the aqueous samples within the chip, while thermal control was achieved by coupling a resistive heater to an IR camera. Fluid routing was managed by bespoke, in-line, solenoid-controlled valves, which could operate at 5-bar and for over 4000 cycles without degrading. Bacteria were thermally or chemically lysed post-concentration, and an on-chip metering chamber aliquoted fixed-volumes of buffer (1% uncertainty for 400nl). DNA from lysed bacteria was amplified on-chip with a limit of detection of 250 E. coli per sample in the final assay.Both sample-preparation and DNA amplification performed well on the prototype system. However, inefficient bacterial elution on-chip post-capture prevented the steps being run sequentially, as insufficient bacteria were released to the lysis region. Future development would fully integrate sample transfer and automate the fluid actuation so as to enable complete sample-in, answer-out capability
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
