402 research outputs found
sj-docx-1-jet-10.1177_15266028231217233 – Supplemental material for An International Expert-Based CONsensus on Indications and Techniques for aoRtic balloOn occLusion in the Management of Ruptured Abdominal Aortic Aneurysms (CONTROL-RAAA)
No full textSupplemental material, sj-docx-1-jet-10.1177_15266028231217233 for An International Expert-Based CONsensus on Indications and Techniques for aoRtic balloOn occLusion in the Management of Ruptured Abdominal Aortic Aneurysms (CONTROL-RAAA) by Mario D’Oria, Rosalba Lembo, Tal M. Hörer, Todd Rasmussen, Kevin Mani, Gianbattista Parlani, Anna Maria Ierardi, Gian Franco Veraldi, Andrea Melloni, Stefano Bonardelli, Sandro Lepidi, Luca Bertoglio, Michele Antonello, Barend Mees, Jonathan Bath, Frederico Bastos Goncalves, Adam W Beck, Sergi Bellmunt, Xavier Berard, Joseph Du Bose, Jacob Budtz-Lilly, Cristiano Calvagna, Martin Czerny, David Dawson, David T McGreevy, George Greenberg, Ajay Savlania, Mark G Davies, Nuno Dias, Mark A Farber, Simone Fajer, Marcelo Ferreira, Marco Franchin, Enrico Gallitto, Ilya Goldin, Tomasz Jakimowicz, Isabelle van Herzeele, Joseph A Hockley, Andrew Holden, Andrea Kahlberg, Kristofer M Charlton-Ouw, Manar Khashram, Drosos Kotelis, Isernia Giacomo, Thomas S Maldonado, Gregory Magee, Blandine Maurel, Luca Mezzetto, Ross Milner, Giuseppe Panuccio, Paivi Helmio, Giovanni Pratesi, Michel M P J Reijnen, Timothy Resch, Vincente Riambau, Benjamin Starnes, Nicla Settembre, Matthew R. Smeds, Salvatore Scali, Anastasios Psyllas, Jonathan Sobocinski, Sundeep Guliani, Glenn Wei Leong Tan, Giovanni Tinelli, Nikolaos Tsilimparis, Santi Trimarchi, Patrick Vriens, Carl Wahlgren, Wouter Van den Eynde, Thodur Vasudevan, Hence JM Verhagen, Sergio Zacà, Nicola Troisi, Anders Wanhainen, Miranda Witheford and Alexander Zimmermann in Journal of Endovascular Therapy</p
Changes in salmonid communities associated with pesticide runoff events
No full textTwo agricultural runoff events involving the pesticide azinphos-methyl occurred in July 2002 on the Wilmot River, Prince Edward Island, Canada, resulting in the death of thousands of fish. The fish communities from three sites on this river had been sampled in 2001, permitting comparisons of brook trout (Salvelinus fontinalis) and rainbow trout (Oncorhynchus mykiss) populations before and after the events. Samples taken immediately after the runoff events suggested that brook trout suffered higher mortality than rainbow trout. Young-of-the-year fish were more affected than older age classes for both species. Sampling in 2003, a year after the pesticide runoff events, revealed salmonid communities that were still skewed towards rainbow trout, and a decrease in the 1+ age class density (2002's young of the year) at affected sites. These results suggest a differential effect of the pesticide azinphos-methyl on salmonid species and age classes under natural conditions, and a subsequent change in population and community structure. The possibility of these pesticide runoff events selecting for rainbow trout, an exotic species, is a consideration in management of agriculturally impacted rivers.PT: J; CR: *PEI DAF, PRINC EDW ISL DEP AG *USEPA, 1998, AZ METH *WHO, 2002, DAT SHEET PEST AZ ME ARNOLD H, 1994, SUBLETHAL CHRONIC EF, P75 ATCHISON GJ, 1987, ENVIRON BIOL FISH, V18, P11 ELSON PF, 1967, J FISH RES BOARD CAN, V24, P731 GORMLEY KL, 2003, THESIS U PRINCE EDWA HANSEN DJ, 1972, B ENVIRON CONTAM TOX, V8, P46 HANSEN JA, 1999, ENVIRON TOXICOL CHEM, V18, P313 JOHNSTON CE, 1980, PROG FISH CULT, V42, P107 MCKIM JM, 1977, J FISH RES BOARD CAN, V34, P1148 MURTHY AS, 1986, TOXICITY PESTICIDES, V2, P143 MUTCH JP, 2002, EFFECTS LAND USE PRA, P94 PARRISH DL, 1998, CAN J FISH AQUAT S1, V55, P281 POST G, 1974, B ENVIRON CONTAM TOX, V12, P312 POWER G, 1980, CHARRS SALMONID FISH, P141 SAUNDERS JW, 1969, J FISH RES BOARD CAN, V26, P695 SMITH JR, 1984, AQUAT TOXICOL, V2, P107 VANLEEUWEN CJ, 1985, AQUAT TOXICOL, V7, P59; NR: 19; TC: 0; J9: ECOTOXICOLOGY; PG: 8; GA: 971RISource type: Electronic(1
Wind-driven changes in Southern Ocean residual circulation, ocean carbon reservoirs and atmospheric CO2
No full textThe effect of idealized wind-driven circulation changes in the Southern Ocean on atmospheric CO2 and the ocean carbon inventory is investigated using a suite of coarse-resolution, global coupled ocean circulation and biogeochemistry experiments with parameterized eddy activity and only modest changes in surface buoyancy forcing, each experiment integrated for 5,000 years. A positive correlation is obtained between the meridional overturning or residual circulation in the Southern Ocean and atmospheric CO2: stronger or northward-shifted westerly winds in the Southern Hemisphere result in increased residual circulation, greater upwelling of carbon-rich deep waters and oceanic outgassing, which increases atmospheric pCO2 by ?20 ?atm; weaker or southward-shifted winds lead to the opposing result. The ocean carbon inventory in our model varies through contrasting changes in the saturated, disequilibrium and biogenic (soft-tissue and carbonate) reservoirs, each varying by O(10–100) PgC, all of which contribute to the net anomaly in atmospheric CO2. Increased residual overturning deepens the global pycnocline, warming the upper ocean and decreasing the saturated carbon reservoir. Increased upwelling of carbon- and nutrient-rich deep waters and inefficient biological activity results in subduction of unutilized nutrients into the ocean interior, decreasing the biogenic carbon reservoir of intermediate and mode waters ventilating the Northern Hemisphere, and making the disequilibrium carbon reservoir more positive in the mode waters due to the reduced residence time at the surface. Wind-induced changes in the model carbon inventory are dominated by the response of the global pycnocline, although there is an additional abyssal response when the peak westerly winds change their latitude, altering their proximity to Drake Passage and changing the depth extent of the southward return flow of the overturning: a northward shift of the westerly winds isolates dense isopycnals, allowing biogenic carbon to accumulate in the deep ocean of the Southern Hemisphere, while a southward shift shoals dense isopycnals that outcrop in the Southern Ocean and reduces the biogenic carbon store in the deep ocean
Innovative Approach of 2D Platformer Mobile Game Development “Super Journey”
No full textThis study investigates the design and development process of “Super Journey”, a 2D platformer mobile game aimed at enhancing user engagement and satisfaction through innovative game mechanics and design. Utilizing the Agile methodology, the development stages included conceptualization, design, implementation using the Unity game engine, and iterative testing and evaluation based on user feedback. This development process involved crafting a detailed game design document, creating initial sketches and prototypes, and integrating graphical elements, animations, and game mechanics. The game features 3 levels with simple controls, visually appealing pixel art, and progressively challenging levels. A survey conducted with 20 participants revealed high overall satisfaction (4.15 out of 5), with particular praise for level design (4.25) and game mechanics (4.2). Feedback indicated areas for improvement, such as balancing difficulty levels and incorporating more diverse obstacles and enemies. The findings underscore the importance of agile, user-centered design in game development and provide insights for future iterations to further enhance the gaming experience. “Super Journey” exemplifies the effective integration of classic platformer elements with modern innovations, highlighting its potential in the competitive mobile gaming market. The results of this research are expected to serve as a reference and inspiration for other game developers to create superior products by combining innovative technology and thoughtful design
Three-Level Multiple Imputation: A Fully Conditional Specication Approach
No full textabstract: Currently, there is a clear gap in the missing data literature for three-level models.
To date, the literature has only focused on the theoretical and algorithmic work
required to implement three-level imputation using the joint model (JM) method of
imputation, leaving relatively no work done on fully conditional specication (FCS)
method. Moreover, the literature lacks any methodological evaluation of three-level
imputation. Thus, this thesis serves two purposes: (1) to develop an algorithm in
order to implement FCS in the context of a three-level model and (2) to evaluate
both imputation methods. The simulation investigated a random intercept model
under both 20% and 40% missing data rates. The ndings of this thesis suggest
that the estimates for both JM and FCS were largely unbiased, gave good coverage,
and produced similar results. The sole exception for both methods was the slope for
the level-3 variable, which was modestly biased. The bias exhibited by the methods
could be due to the small number of clusters used. This nding suggests that future
research ought to investigate and establish clear recommendations for the number of
clusters required by these imputation methods. To conclude, this thesis serves as a
preliminary start in tackling a much larger issue and gap in the current missing data
literature.Dissertation/ThesisMasters Thesis Psychology 201
B2K template images for neuroimaging in baboon
No full textB2K template images for neuroimaging in baboon
Black KJ, Snyder AZ, Koller JM, Gado MH, Perlmutter JS
Washington University School of Medicine, St. Louis, MO
28 July 2000 (last updated 15 February 2001)
please reference this page as purl.org/net/kbmd/b2k
Brief description
The b2k and b2kf images ("b" for baboon, "f" for blood flow) are intended for use as templates for automated 3D image registration algorithms for neuroimaging stidies in baboons. The b2k template is an average (after spatial normalization) of T1-weighted MRI images from 9 normal baboons, and the b2kf template is averaged from 397 [15O]water PET images in 7 normal baboons. Coordinates from the 1968 Davis and Huffman photomicrographic atlas of baboon brain can be derived from pixel coordinates in these images according to the conventions described in the attached appendix.html file (they are automatically computed by SPM based on the supplied .hdr files). Details of the images' formation and a test of the accuracy of our image registration software when registering MPRAGE and PET blood flow images to these templates appear in NeuroImage. The GIF files show a quick view of one slice of the template images. Corresponding images are also available for use with Macaca nemestrina (the pig-tailed macaque) and Macaca fascicularis (cynomolgus monkey).
Terms of use
Cite the following reference in any publications that make use of these images: Black KJ, Snyder AZ, Koller JM, Gado MH, Perlmutter JS: Template images for nonhuman primate neuroimaging 1. Baboon. NeuroImage 2001; 14(3):736-743. DOI 10.1006/nimg.2001.0752
Download instructions
1) choose desired image format
2) download one of the image files in that row (choose .zip or .tar.gz)
3) the *.txt and/or *.ifh files are in ASCII format and explain image conventions. Highly suggested reading!
4) I would like to know if you find these images useful. Please email me ([email protected]).
SPM format (Neurologic orientation, R on R) b2k_spm_images.zip b2k_spm_images.tar.gz
Analyze format = 4dint format (Radiologic orientation, R on L) b2k_ana_images.zip b2k_ana_images.tar.gz
4dfp format (WUSM NIL internal format) b2k_4dfp_images.zip b2k_4dfp_images.tar.gz
*The "tight" mask approximates actual brain and was created by hand from b2k.4dfp.img using Analyze AVW. Its volume is 185 ml (185479 voxels). Note: Bonferroni correction for overall p -7, corresponding to a Z score of about 5.14 (two tails) or 5.01 (one tail). The loose mask (used for image registration with our local software) was created by dilating the tight mask slightly; its volume is 242 ml (241739 voxels).</p
HELIOS-K 2.0 Opacity Calculator and Open-source Opacity Database for Exoplanetary Atmospheres
No full textComputing and using opacities is a key part of modeling and interpreting data of exoplanetary atmospheres. Since the underlying spectroscopic line lists are constantly expanding and currently include up to ~1010–1011 transition lines, the opacity calculator codes need to become more powerful. Here we present major upgrades to the HELIOS-K GPU-accelerated opacity calculator and describe the necessary steps to process large line lists within a reasonable amount of time. Besides performance improvements, we include more capabilities and present a toolbox for handling different atomic and molecular data sets, from downloading and preprocessing the data to performing the opacity calculations in a user-friendly way. HELIOS-K supports line lists from ExoMol, HITRAN, HITEMP, NIST, Kurucz, and VALD3. By matching the resolution of 0.1 cm−1 and cutting length of 25 cm−1 used by the ExoCross code for timing performance (251 s excluding data read-in time), HELIOS-K can process the ExoMol BT2 water line list in 12.5 s. Using a resolution of 0.01 cm−1, it takes 45 s, equivalent to about 107 lines s−1. As a wavenumber resolution of 0.01 cm−1 suffices for most exoplanetary atmosphere spectroscopic calculations, we adopt this resolution in calculating opacity functions for several hundred atomic and molecular species and make them freely available on the open-access DACE database. For the opacity calculations of the database, we use a cutting length of 100 cm−1 for molecules and no cutting length for atoms. Our opacities are available for downloading from https://dace.unige.ch/opacityDatabase and may be visualized using https://dace.unige.ch/opacity
A bioinformatic study on the feasibility of a cross-species proteomics analyses of mycobacteria
No full textIncludes abstract.
Includes bibliographical references
A Reading of the David and Goliath Narrative in Greek and Hebrew
No full textThe story of David and Goliath existed in antiquity in two distinct literary versions, a short version found in LXXB and a longer version reflected in the MT. This thesis proposes that each version is worthy of study in its own right and offers a close literary reading of the narrative of David and Goliath in the Greek text of 1 Reigns 16-18. In this study we explore a method of reading the Septuagint that recognizes it is both a document in its own right and a translation of a Hebrew original. In offering this reading of the septuagintal version of the David and Goliath narrative we will highlight the literary difference between the two final versions of the story that exist in LXXB and MT
Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment
No full textPancreatic cancer remains a formidable challenge due to limited treatment options and its aggressive nature. In recent years, the naturally occurring anticancer compound juglone has emerged as a potential therapeutic candidate, showing promising results in inhibiting tumor growth and inducing cancer cell apoptosis. However, concerns over its toxicity have hampered juglone’s clinical application. To address this issue, we have explored the use of polymeric micelles as a delivery system for juglone in pancreatic cancer treatment. These micelles, formulated using Poloxamer 407 and D-α-Tocopherol polyethylene glycol 1000 succinate, offer an innovative solution to enhance juglone’s therapeutic potential while minimizing toxicity. In-vitro studies have demonstrated that micelle-formulated juglone (JM) effectively decreases proliferation and migration and increases apoptosis in pancreatic cancer cell lines. Importantly, in-vivo, JM exhibited no toxicity, allowing for increased dosing frequency compared to free drug administration. In mice, JM significantly reduced tumor growth in subcutaneous xenograft and orthotopic pancreatic cancer models. Beyond its direct antitumor effects, JM treatment also influenced the tumor microenvironment. In immunocompetent mice, JM increased immune cell infiltration and decreased stromal deposition and activation markers, suggesting an immunomodulatory role. To understand JM’s mechanism of action, we conducted RNA sequencing and subsequent differential expression analysis on tumors that were treated with JM. The administration of JM treatment reduced the expression levels of the oncogenic protein MYC, thereby emphasizing its potential as a focused, therapeutic intervention. In conclusion, the polymeric micelles-mediated delivery of juglone holds excellent promise in pancreatic cancer therapy. This approach offers improved drug delivery, reduced toxicity, and enhanced therapeutic efficacy
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