1,760 research outputs found
N. Kasumi Clements, Sites of the Ascetic Self: John Cassian and Christian Ethical Formation
No full textItem does not contain fulltextN. Kasumi Clements, Sites of the Ascetic Self: John Cassian and Christian Ethical Formation Notre Dame:University of Note Dame Press ,2020 978026810785
Binding Of Flexible And Constrained Ligands To The Grb2 Sh2 Domain: Structural Effects Of Ligand Preorganization
No full textStructures of the Grb2 SH2 domain complexed with a series of pseudopeptides containing flexible (benzyl succinate) and constrained (aryl cyclopropanedicarboxylate) replacements of the phosphotyrosine (pY) residue in tripeptides derived from Ac-pYXN-NH(2) (where X = V, I, E and Q) were elucidated by X-ray crystallography. Complexes of flexible/constrained pairs having the same pY + 1 amino acid were analyzed in order to ascertain what structural differences might be attributed to constraining the phosphotyrosine replacement. In this context, a given structural dissimilarity between complexes was considered to be significant if it was greater than the corresponding difference in complexes coexisting within the same asymmetric unit. The backbone atoms of the domain generally adopt a similar conformation and orientation relative to the ligands in the complexes of each flexible/constrained pair, although there are some significant differences in the relative orientations of several loop regions, most notably in the BC loop that forms part of the binding pocket for the phosphate group in the tyrosine replacements. These variations are greater in the set of complexes of constrained ligands than in the set of complexes of flexible ligands. The constrained ligands make more direct polar contacts to the domain than their flexible counterparts, whereas the more flexible ligand of each pair makes more single-water-mediated contacts to the domain; there was no correlation between the total number of protein-ligand contacts and whether the phosphotyrosine replacement of the ligand was preorganized. The observed differences in hydrophobic interactions between the complexes of each flexible/constrained ligand pair were generally similar to those observed upon comparing such contacts in coexisting complexes. The average adjusted B factors of the backbone atoms of the domain and loop regions are significantly greater in the complexes of constrained ligands than in the complexes of the corresponding flexible ligands, suggesting greater thermal motion in the crystalline state in the former complexes. There was no apparent correlation between variations in crystal packing and observed structural differences or similarities in the complexes of flexible and constrained ligands, but the possibility that crystal packing might result in structural variations cannot be rigorously excluded. Overall, it appears that there are more variations in the three-dimensional structure of the protein and the ligand in complexes of the constrained ligands than in those of their more flexible counterparts.National Institutes of Health (GM 84965)National Science Foundation (CHE 0750329)Robert AWelch Foundation (F-652)Norman Hackerman Advanced Research ProgramTexas Institute for Drug and Diagnostic DevelopmentWelch Foundation Grant #H-F-0032ChemistryBiochemistr
Interview with Major H. R. Brearley
No full textInterview with Major H. R. Brearley by John Clements.
Major H. R. Brearley talks about his early days with the ABC. One of the first radio technicians, he originally worked as a telephone mechanic (technician) and recalls learning on-the-job in the early days of radio before there was training available.
This sound recording is part of the John Clements Oral History Collection
This date in Alabama history: Hon. John H. Bankhead by W.J. Boles
No full textThis is an item in the Clements family papers collection
Promissory note for the payment for renting Mitchell Hall from John Mitchell, signed by C.H. Clevelane, Selma, January 1st, 1854
No full textAn item in the Clements Family Papers Collection
Bull trout conservation and recovery in the Odell Lake core area: distribution, behavior, ecology, and fisheries evaluations (2013-2014)
No full textMichael H. Meeuwig, Steve J. Starcevich, Elizabeth J. Bailey, Shaun P. Clements, and Joshua L. McCormick.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 63-68).Funding for this project was provided in part by USFWS (F14AF01131 and F13AF01080).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Recent Decisions
No full textComments on recent decisions by Carl F. Eiberger, Donald W. Bebenek, Walter C. Clements, Robert J. Hepler, Norman H. McNeil, John P. Coyne, Mark S. Tolle, Robert D. LeMense, Michael C. Dionise, and John W. Houck
Recent Decisions
No full textComments on recent decisions by Carl F. Eiberger, Donald W. Bebenek, Walter C. Clements, Robert J. Hepler, Norman H. McNeil, John P. Coyne, Mark S. Tolle, Robert D. LeMense, Michael C. Dionise, and John W. Houck
Recent Decisions
No full textComments on recent decisions by Carl F. Eiberger, Donald W. Bebenek, Walter C. Clements, Robert J. Hepler, Norman H. McNeil, John P. Coyne, Mark S. Tolle, Robert D. LeMense, Michael C. Dionise, and John W. Houck
John H. McIntire.
No full textHalf-length portrait of an older man holding a book in one hand and a pair of spectacles in the other. Light hand coloring.; Case: leather with floral pattern and two hook-and-eye locks, pebbled octagonal mat, red velvet pad with impressed design. Image likely predates case.; Non-contemporary ink inscription in back of case: Date of picture unknown.; Non-contemporary engraved inscription on back of image plate: John H. McIntire 1428 Regent St Niles Mich Nov. 5, 1962 Date of picture unknown.; Title devised by cataloger
- …
