48 research outputs found
Calibration chain transformation improves the comparability of organic hydrogen and oxygen stable isotope data
No full textStable hydrogen and oxygen isotopic compositions (δ2H and δ18O, respectively) of animal tissues have been used to infer geographical origin or mobility based on the premise that the isotopic composition of tissue is systematically related to that of local water sources. Isotopic data for known-origin samples are required to quantify these tissue–environment relationships. Although many of such data have been published and could be reused by researchers, differences in the standards used for calibration and analytical procedures for different datasets limit the comparability of these data. We develop an algorithm that uses results from comparative analysis of secondary standards to transform data among reference scales and estimate the uncertainty inherent in these transformations. We apply the algorithm to a compilation of known-origin keratin data published over the past ~20 years. We show that transformation improves the comparability of data from different laboratories, and that the transformed data suggest ecophysiologically meaningful differences in keratin–water relationships among different animal groups and taxa. The compiled data and algorithms are freely available in the ASSIGNR r-package to support geographical provenance research, and more generally offer a methodology overcoming several challenges in geochemical data integration and reuse
measurements of explosives, urea, and inorganic nitrates by elemental analyzer/isotope ratio mass spectrometry using thermal decomposition
No full textHydrogen and oxygen isotope values in hydrogen peroxide
No full textHydrogen peroxide (H 2 O 2 ) is a widely used oxidizer with many commercial applications; unfortunately, it also has terrorist-related uses. We analyzed 97 hydrogen peroxide solutions representing four grades purchased across the United States and in Mexico
Medical Update (2003)
No full textVolume1/2003_SummerUPdate University of Utah Health System Summer 2003 W H A T \u27 S I N S I DE Q ui 2 Surviving Melanoma page 4 Breast Cancer Surgery: Making an Informed Decision page 6 Continuing Medical Education Schedule page 8 Latest Surgery, Medication Help U Physicians Fight Glaucoma By Phil Sahm Curds Hancock lines up putts and splits the fairways from a little dif-ferent perspective when he plays golf these days. It\u27s fair to say that Hancock, 37, looks at every aspect of life differently since learning three years ago that he has glaucoma, an insidious disease that steals sight and can cause permanent blindness. More than 2 million Americans have open- angle glaucoma- the most common form of the disease- and half of them may be undiagnosed. Hancock, married and the father of three children ages 18 months to 8 years, was at risk for losing his vision- but he and his doctors caught the disease before it caused major damage to his optic nerve. In May, the Ogden resident went to the University of Utah\u27s John A. Moran Eye Center to undergo one of the latest advancements in glaucoma treat-ment- non- penetrating surgery. Hancock\u27s surgeon, Norman A. Zabriskie, M. D., associate professor of ophthalmology and visual sciences at the U School of Medicine, made an incision wwi V. Glaucoma won\u27t stop Curtis Hancock from enjoying golf or other activities since he underwent one of the latest surgical techniques at the U\u27s John A. Moran Eye Center. continued on page 2 Fighting Glaucoma Patient Benefits from Latest Surgery, Medication ... continuedfrom cover to allow fluid to drain from his eye and relieve pres-sure on the optic nerve. In the past, such surgery involved a cut that penetrated the full thickness of the eye. But using the non- penetrating technique, Zabriskie cut only partly into Hancock\u27s eye. The procedure not only provides fluid drainage to reduce pressure on the optic nerve, but also carries a lower risk of bleeding or infection compared with operations that use deeper incisions. The surgery worked. Pressure in Hancock\u27s eye is dramatically lower and damage to his optic nerve has been stopped. " That was great to hear," Hancock said. Hancock is a rarity among people with glaucoma: He had forewarning of the disease. Glaucoma often develops from a medication he was taking for an inflamed iris, a condition called iritis. The medication also caused him to develop cataracts, which require surgery. Most people aren\u27t on the lookout for glaucoma and don\u27t know when they develop it because the disease occurs with no noticeable symptoms. But glaucoma is the second- leading cause of permanent blindness ( behind diabetes) in the country. Glaucoma is the second-leading cause of permanent blindness in the country. Fluid naturally flows in and out of the eye, but in open- angle glaucoma the fluid drains too slowly. The slow drainage forces pressure to build in the eye, which damages the optic nerve. When the optic nerve becomes damaged it reduces peripheral vision, and if the problem goes unchecked, blindness can occur. People over age 60 are at greater risk of develop-ing glaucoma, and African- Americans are particularly vulnerable to the disease. African- Americans over age 80 are five times more likely to get glaucoma and are four times likelier to be blinded by the disease as Caucasians. Glaucoma is the leading cause of blindness among African- Americans. The change in eye pressure and optic nerve damage occurs imperceptibly, and glaucoma often goes undetected until some peripheral vision is lost. Vision loss may be so slight at first that the individual doesn\u27t notice. Ophthalmologists usually find the signs of glau-coma during a complete eye examination. If the eye pressure, also called ocular pressure, is above a reading of 22, or if the optic nerve looks suspicious, the patient should undergo further tests. High ocular pressure doesn\u27t always signal glaucoma, but it often does. Conversely, some people with glaucoma don\u27t have high eye pressure. After developing glaucoma, Hancock took daily eye drops to reduce the ocular pressure, but the drops eventually stopped working. " That\u27s when I started to get nervous," Hancock said. Then, he took an oral medication to reduce the pressure. The medicine worked but had an intolerable side effect- it made him vomit. Finally, in May, he came to the Moran Eye Center for surgery. Zabriskie, Alan S. Crandall, M. D., professor of ophthalmology and visual sciences and director of Glaucoma and Cataract at Moran, and Jason A. Goldsmith, M. D., assistant professor of ophthalmology and visual sciences, are the U\u27s glaucoma experts. They offer the full range of the latest medications, laser tech-nology, and surgery. The first news any glaucoma patient receives is not good: nerve damage and vision loss from the disease are irreversible, meaning the only medical recourse is to prevent further damage, according to Zabriskie. " We don\u27t kid ourselves that we can cure the disease," he said. " We just try to keep it from getting worse." Advancements in glaucoma treatment are helping in that effort. Glaucoma medications today are the best ever, according to Zabriskie. New eye drops reduce ocular pressure by increas-ing the fluid outflow from the eye through a second-ary route. These drops can be taken once a day, with the primary side effect of causing irritation or darken-ing of the eye. Oral medications also reduce eye Glaucoma often goes undetected until some peripheral vision is lost. pressure, but, as in Hancock\u27s case, the side effects can be more pro-nounced. Drops are the most commonly prescribed medication for glaucoma. Newer medicines, used during an operation, also increase the chance of successful surgery, and biological agents are being developed that may further help surgical outcomes. If drugs don\u27t decrease ocular pressure to stop damage to the optic nerve, laser surgery or invasive surgery are the next options. Laser surgery, in which high intensity beams of light are aimed at parts of the eye, changes the anatomy of the primary path where fluid drains, increasing the outflow and reducing pressure. In the past, once laser surgery was per-formed it couldn\u27t be repeated in the same area. But new technology is making it possible to repeat laser surgery if necessary, according to Zabriskie. Many advances are coming in traditional surgery, in which incisions are made to cut new pathways in the eye and increase fluid drainage. New drugs also prevent scar tissue from forming over incisions made to keep fluid draining from the eye. " That has definitely increased our success," Zabriskie said. The non- penetrating surgery that Hancock underwent is particularly encouraging because of the lower risk of complications. As advances in technolo-gy, surgical technique, and drugs enhance the ability to stop the disease from progressing, researchers are learning more about glaucoma. Physicians and other researchers, for example, are learning that cornea thickness may indicate the likelihood of developing glaucoma: the thicker the cornea, the less likely the disease will occur. And- as in nearly every other aspect of medi-cine- genetics may hold the ultimate key to glaucoma as researchers look for a gene, or genes, that predispose people to the disease, according to Zabriskie. That would change the picture for millions of people. For the present, Curtis Hancock and others in Utah and the Intermountain West count on the U\u27s Moran Eye Center for the best current knowledge and technology to stop an incur-able disease from taking their sight. That gives hope for the future and some peace of mind. " It\u27s been a roller- coaster the past few years," Hancock said, " but I hope we\u27re on the right track now." ® For more information, call the John A. Moran Eye Center, ( 801) 581- 2352. University of Utah Hospitals & Clinics toll- free referral and consultation: 1 - 8 0 0 - 4 5 3 - 0 1 2 2 in Utah, 1 - 8 0 0 - 6 6 2 - 0 0 5 2 outside Utah Surviving Melanoma DQ LJ I < H D O X D D Patient Joins " Gene Hunt" to Help Fight Disease By Cindy Fazzi When the death of Maureen Reagan, daughter of former President Ronald Reagan, made headlines almost two years ago, it struck Bonnie Myers in a very personal way. Reagan died of melanoma- a type of skin cancer- on Aug. 8, 2001, less than a month after a cancerous freckle on Myers\u27 shoulder and another one on her stomach were surgically removed. " Maureen Reagan\u27s death really hit me," said Myers, a 52- year- old wife and mother of two from Salt Lake City. " Here was a woman who was famous, well- educated, and had money. All of that did not save her from melanoma." Melanoma develops in the cells that produce melanin, the pigment that gives skin its color. Melanoma is the deadliest type of skin cancer because it\u27s more likely than other skin cancers to spread to different parts of the body. However, if caught early, it\u27s almost entirely curable. Other common kinds of skin cancer are basal cell carcinoma and squamous cell carcinoma. The Skin Cancer Foundation says occurrence of melanoma is rising faster than any other cancer. In 1935, only one in 1,500 Americans developed melanoma, but today the rate is one in 71. Myers, a skilled horsewoman and an avid skier, was first tested for melanoma in June 2001. A month later, R. Dirk Noyes, M. D., a surgical oncologist and co- director of the Multidisciplinary Melanoma Clinic at the University of Utah\u27s Huntsman Cancer Institute ( HCI), removed Myers\u27 melanoma. Today she\u27s cancer- free, but by no means complacent. Myers and her 72- year- old mother, Catherine Ziegenbalg, are participating in a clinical investigation being conducted at HCI\u27s Tom C. Mathews Jr. Familial Melanoma Research Clinic ( FMRC). Like her daughter, Ziegenbalg had melanoma but is now cancer- free. The FMRC is devoted to studying the genetic causes and inheritance patterns of familial melanoma. It also serves as an educational resource for individuals at high risk for the cancer. The research focuses on the role of genes in the development of melanoma. About 15 years ago, U researchers localized the first gene- now called pi6- which is known to increase the likelihood of developing melanoma. " PI6 is a gene that frequently is mutated and is passed on within a family, from generation to generation," said Sancy A. Leachman, M. D., Ph. D., FMRC director and assistant professor in the U\u27s Department of Dermatology. Melanoma: Facts and Figures Skin cancer is the most © For more information, call HCFs melanoma program, ( 801) 585- 9427. Leachman said the current research builds on the previous study by trying to understand why p l 6 causes melanoma and how it interacts with environmental factors, such as sun expo-sure. " Just because you have a mutation in the p l 6 gene doesn\u27t mean you\u27ll automatically get melanoma. It simply means that your chance of getting it is significantly enhanced, especially if you happen to be living in a really sunny place," she said. Leachman said p l 6 is mutated in only about 25 percent of familial melanoma patients, which implies that the majority may have other genes that make them susceptible to melanoma. FMRC wants to investigate these other genes. " Basically, we\u27re doing a gene hunt," said Leachman. Myers and her mother became part of this " gene hunt" in March. Myers said their participation involved giving blood sample, a thorough body skin exam, and photographing their freckles and moles for close monitoring. They also completed an extensive questionnaire about such things as how often they were outdoors and for how long. All clinical services within the research program are free, but Leachman said it\u27s not a replacement for immediate care. For Myers and Ziegenbalg, their participation helped them keep tabs on their condition. In fact, Leachman did a biopsy of a suspicious lesion on Ziegenbalg\u27s shoulder. It turned out to be basal cell cancer, a slow- growing cancer that seldom spreads to other parts of the body. Ziegenbalg had the lesion removed in Florida, where she lives. Not every melanoma patient is qualified to par-ticipate in the clinical study, but Myers was a logical candidate. She has light, freckled skin, blue eyes, and red hair- some of the physical charac-teristics typical-ly associated with melanoma patients. Myers loves being outdoors and her mother also had melanoma. Myers grew up in New Jersey, where her family had a summer home by the beach. " I spent a lot of time at the beach or riding horses and generally staying out-doors," said Myers. " Growing up, nobody ever told me about the danger of skin cancer or the impor-tance of sunscreen and other forms of protection from the sun." Although Myers no longer spends as much time outdoors as she used to, she\u27s more vigilant in protecting herself when she does. She wears long sleeves and a hat as much as possible, applies sunscreen daily, and checks her skin very closely. She also makes sure her two teen- agers do the same. Myers said a major advantage of participating in the study is access to experts such as Leachman. Moreover, the study gives Myers the satisfaction that she\u27s doing something to help fight the disease. Myers even ventured down to sunny Mexico in June. " I used to be petrified. I didn\u27t want to do anything outdoors anymore, but Dr. Leachman told me develop-ing melanoma does not mean my life is over," she said. " Now I\u27m slowly getting over my fear." common type of cancer in the U. S., according to the National Cancer Institute. It says 40 per-cent to 50 percent of Americans who live to age 65 will have skin cancer at least once. The American Cancer Society estimates that 54,200 Americans will be diagnosed with melanoma this year. Out of that, 29,900 are men and 24,300 women. The organization says 7,600 people will die of skin cancer this year. Sancy A. Leachman, M. D., HCI researcher and assistant professor in the U\u27s Department of Dermatology, is studying the genetic causes of familial melanoma. University of Utah Hospitals & Clinics toll- free referral and consultation: 1 - 8 0 0 - 4 5 3 - 0 1 2 2 in Utah, I - 8 O O - 6 6 2 - O O 5 2 outside Utah Breast Cancer Surgery: Making an Informed Decision By Cindy Fazzi Kari Ellingson and Kathy Howa aren\u27t related. They don\u27t even know each other. But they have a lot in common. Both are 40- something. They live and teach in the Salt Lake City area. Each woman was diagnosed with breast cancer and they both turned to the same University of Utah Hospital surgeon for help. While they both agreed that surgery was the best treatment for breast cancer, they did not choose the same type of surgery. In Ellingson\u27s case, a biopsy showed that most of the microcalcifications scattered throughout her right breast were pre- malignant, a change called ductal car-cinoma in situ. But she also had a small area of true invasive breast cancer, proven by a needle biopsy. She had been advised to have a lumpectomy, a type of surgery that removes only the part of the breast where the tumor is located. Not satisfied with the information she had at hand, Ellingson decided to get a second opinion. She sought the help of Edward W. Nelson, M. D., professor and chief of the U medical school\u27s Division of General Surgery. Nelson thought Ellingson had too many microcalcifications for lumpectomy to be as effective as a mastectomy with reconstruction. " I knew nothing about breast can-cer, but after my diagnosis, I learned in a hurry," said Ellingson, assistant vice president for Student Development and clinical associate professor in edu-cational psychology at the U. After doing her own research, the 48- year-old wife and mother of two chose to have her right breast removed, a proce-dure known as simple mastectomy. Nelson was her surgeon. She also decided to have breast reconstruction at the same time as her mastectomy. W. Bradford Rockwell, M. D., associate professor and chief of the U\u27s Division of Plastic and Reconstructive Surgery, performed that surgery. Ellingson\u27s mastectomy lasted two hours and the breast reconstruction, six hours. Howa had braced herself for cancer diagnosis because of her family history. Although she\u27s the first in her family to have breast cancer, her grandmother, mother, and sister all had uterine cancer. The tumor in Howa\u27s right breast was small ( 1.5 millimeters), but it was invasive cancer. " At first I wanted a mastectomy. But I told Dr. Nelson I was willing to do whatever he thought was best for me," said Howa, 42, of Midvale. Nelson ultimately performed a lumpectomy and sentinel procedure under Howa\u27s right arm. A sentinel node is the first place where cancer is likely to spread. Howa\u27s surgery lasted four hours and she went home after two days. She returned to her job as a physical education teacher at Rowland Hall- St. Mark\u27s School just a few days after surgery. She then began chemotherapy, which lasted six months. " I would have chosen mastectomy, but Dr. Nelson was absolutely right about a lumpectomy. He helped me take the right path," she said. Team Approach Actually, Nelson\u27s recommendation reflected not just his opinion, but the consensus of an entire team. In a Breast Cancer Care Conference held every other week, doctors involved in treating breast cancer patients- surgeons, radiolo-gists, pathologists, plastic surgeons, oncologists, and radiation oncologists- meet to discuss options available to patients. " My job is to educate a patient about all her options, not necessarily to change her mind about a procedure," said Nelson, who presides over the conference. " But when 1 do make a recommendation, she can be sure that she\u27s getting the best thinking of the entire Breast Cancer Care Conference." He said that for most patients, getting the opinion of several doctors at once boosts their confidence and helps them make a decision. Ellingson and Howa said they definitely welcomed the input of the group. At a recent conference, 21 doctors, residents, nurses, and clinical researchers discussed the options available to five patients. Detailed medical histories were presented, including everything from mammogram results to evaluations of a patient\u27s psycho-logical and emotional readiness to undergo surgery. Nelson said the Hospital\u27s Tumor Board used to evaluate all types of cancer patients, but the increase in breast cancer patients and the particular issues they face merited a separate conference. Ellingson agreed that breast cancer is unique because it\u27s inherently linked to a woman\u27s self- esteem and identity. " This is not like any other disease," she said. " 1 can understand that some women are very attached to their breasts." Lumpectomy vs. Mastectomy Given this context, counseling breast cancer patients on surgery can be downright difficult. " The problem is that breast conservation is not for everyone," said Nelson. " For some women, there\u27s no other choice but mastectomy." But Nelson also expressed concern that many women assume removing an entire breast is better than other treat-ments. He said there are women with family history of breast cancer who want to remove both breasts as a preventive meas-ure even before they get the disease. " I let patients know that national studies have shown that the local recurrence rate is the same for both mastectomy and lumpectomy when the patient receives the procedure appropri-ate for her situation," said Nelson. Ellingson said if she were to advise a woman diagnosed with breast cancer, she would tell her to look at the big picture. " It\u27s important to get a second opinion," said Ellingson. " Take the conservative approach if you can, but if not, take advantage of what science and technology has to offer." Howa believes that if the cancer is small enough, lumpec-tomy might be the answer. " I didn\u27t always think this way," she said. " But now I know that lumpectomy is very effective and mastectomy is not necessarily better." A year after breast cancer surgery, both women say they\u27re happy with their choices. " I\u27m lucky that I had top- notch surgeons in a top- notch hospital. It\u27s as good as it gets," said Ellingson. As for Howa, she said: " I feel great. I\u27ve never felt better." ifj For more information on breast cancer surgery, call the Division of General Surgery, ( 801) 581- 7738. For information on breast reconstruction, call the Division of Plastic and Reconstructive Surgery, ( 801) 585- 6839. , M. D., professor and chief of the U general surgery division, attended a meet-evaluate options available to patients. University of Utah Hospitals & Clinics toll- free referral and consultation: 1 - 8 0 0 - 4 5 3 - 0 1 2 2 in Utah, 1 - 8 0 0 - 6 6 2 - 0 0 5 2 outside Utah U N I V E R S I T Y OF U T AH S C H O O L O F M E D I C I NE C O N T I N U I N G M E D I C A L E D U C A T I ON September 12: Ophthalmology Clinical Faculty Day October 3- 4: Western Intermountain Neurological Site: John A. Moran Eye Center, Organization Meeting University of Utah, Salt Lake City, UT Site: University Park Marriott, Chair: Mark D. Mifflin, M. D. Salt Lake City, UT Credit: 7 AMA Category 1 hours Chair: Kathleen Digre, M. D. Contact: Elaine Peterson Credit: 8 AMA Category 1 hours ( 801) 585- 3719 ( phone) Contact: Carrie Allen ( 801) 581- 3357 ( fax) ( 801) 359- 0700 ( phone) elaine. peterson@ hsc. utah. edu ( 801) 359- 5799 ( fax) carrie@ insiteevents. com September 20: Refugee Health Overview Site: Huntsman Cancer Institute Auditorium, University of Utah, Salt Lake City, UT March 12: Ophthalmology Residents/ Alumni Day Conference Chair: Cynthia Willard, M. D., M. P. H Site: John A. Mor
Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation
No full textWe explored whether isotope ratio mass spectrometry (IRMS) is useful to investigate the origin of falsified antimalarials. Forty-four falsified and genuine antimalarial samples (artesunate, artemether-lumefantrine, dihydroartemisinin-piperaquine and sulphamethopyrazine-pyrimethamine) were analyzed in bulk for carbon (C), nitrogen (N), and oxygen (O) element concentrations and stable isotope ratios. The insoluble fraction (“starch”) was extracted from 26 samples and analyzed. Samples of known geographical origin maize, a common source of excipient starch, were used to produce a comparison dataset to predict starch source. In both an initial (n = 18) and a follow-on set of samples that contained/claimed to contain artesunate/artemether (n = 26), falsified antimalarials had a range of C concentrations less than genuine comparator antimalarials and δ13C values higher than genuine comparators. The δ13C values of falsified antimalarials suggested that C4 plant-based organic material (e.g., starch derived from maize) had been included. Using the known-origin maize samples, predictions for growth water δ18O values for the extracted “starch” ranged from − 6.10 to − 1.62‰. These findings suggest that IRMS may be a useful tool for profiling falsified antimalarials. We found that C4 ingredients were exclusively used in falsified antimalarials versus genuine antimalarials, and that it may be possible to predict potential growth water δ18O values for the starch present in falsified antimalarials
Transporte sedimentar longitudinal e morfodinâmica praial: exemplo do litoral norte de Santa Catarina
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em GeografiaA presente tese buscou aprofundar a compreensão da interação entre processos longitudinais e ortogonais na definição do comportamento morfodinâmico do perfil praial. A pesquisa foi desenvolvida a partir do exemplo de sistemas praiais de diferente configuração planimétrica do litoral norte de Santa Catarina, Brasil, submetidos à incidência oblíqua de ondas de S/SE e ENE. A metodologia adotada incluiu: a análise de perfis de praia e da granulometria dos sedimentos da face praial; a propagação do regime de ondas; o estabelecimento do balanço de transporte sedimentar longitudinal, apoiado na calibração de equações empíricas com o uso de traçadores fluorescentes; a classificação do perfil praial baseada no parâmetro ômega e a análise de sua capacidade em prever o comportamento morfodinâmico de praias submetidas a um regime misto de ondas e correntes longitudinais. Os resultados obtidos apontaram a presença de dois domínios granulométricos e morfodinâmicos distintos na área de estudo, com o predomínio de areia média e estado morfodinâmico intermediário a reflectivo, associado às praias mais expostas e de areia fina e comportamento dissipativo a intermediário, nas praias mais protegidas. O modelamento do regime de ondas evidenciou a ocorrência de fluxo hidrodinâmico longitudinal dominante para norte, com intensidade modulada pelo grau de exposição das praias. Os experimentos com traçadores fluorescentes apontaram a equação de Kamphuis-1991 como a mais adequada para o estabelecimento do balanço sedimentar longitudinal na área de estudo. O balanço sedimentar confirmou a ocorrência de deriva litorânea resultante para norte, associada à incidência de ondas de quadrante sul. As taxas de transporte oscilaram entre 200.000 a 550.000m3/ano nas praias expostas e entre 20.000 a 200.000m3/ano nas praias mais protegidas. A pesquisa apontou o impacto da deriva litorânea resultante nos processos morfossedimentares praiais, com o aumento e redução das taxas de transporte entre setores adjacentes definindo, respectivamente, tendência erosiva e deposicional, resultando no incremento da granulometria média dos sedimentos no primeiro caso, e na redução do tamanho médio do grão, no segundo. A declividade da face praial acompanhou largamente a granulometria média e as oscilações no transporte sedimentar, mas os resultados apontaram a influência da interação entre processos ortogonais e longitudinais na determinação do parâmetro ao longo das praias. Nesse sentido, os resultados indicaram maior influência dos processos longitudinais no comportamento morfodinâmico do perfil praial nos setores praiais menos expostos, onde a capacidade previsional do parâmetro ômega foi limitada. Nos setores praiais mais expostos, o comportamento do perfil praial sugere maior interação entre processos ortogonais e longitudinais, com maior adequação do parâmetro ômega em prever o estado morfodinâmico da praia. Os resultados demonstraram a importância do transporte longitudinal para os processos morfossedimentares praiais em diferentes escalas espaço-temporais. A verificação de ajuste entre transporte sedimentar longitudinal e declividade da face praial em outros setores costeiros e em presença de maior espectro de energia permitirá avaliar o alcance da relação identificada no presente estudo, ampliando os horizontes analíticos relativos à configuração dos processos morfodinâmicos praiais e os subsídios científicos à gestão do estoque sedimentar costeiro.This thesis examines the influence of longshore and shore-normal coastal processes interaction on beach morphodynamic behavior. The research was developed from the example of different planimetric systems beach of the north coast of Santa Catarina, Brazil, subjected to oblique wave from S/SE and ENE. The methodology adopted in this research included: beach profile survey and beach face sediment control; wave propagation modelling; the use of fluorescent tracer to calibrate some longshore sediment transport equations, in order to establish the annual longshore sediment budget in the study area; the beach morphodynamic classification from application of omega parameter and the analysis of its ability to predict the morphodynamic behavior of sandy beaches subjected to mixed regime of waves and significant alongshore currents. The results found indicated the occurrence of two distinct granulometric domains in the study area with a predominance of medium sand beaches combined with the highest exposure coast and fine sand beaches on less exposed sectors. The first one domain is marked by the predominance of intermediate to reflective beach state and the second one by dissipative to intermediate beach morphology. The wave characteristics in the surf zone confirmed the occurrence of hydrodynamic dominant vectors northwards in the study area, with their intensity modulated by degree of coastline exposure. The use of sand fluorescent tracers pointed the Kamphuis-1991 equation as the most suitable to establish the annual alongshore sediment buget in the study area. The calculation of littoral drift indicate a net alongshore sediment transport towards the north, associated with waves from the southern quadrant. The magnitude of the rates found were of 200.000 to 550.000m3/yr on exposed beaches and of 20.000 to 200.000m3/yr on semi-exposed beaches. The results pointed out the impact of the longshore sediment transport on predominant morphosedimentary beach processes, with increasing and decreasing sediment transport rates reflecting erosional and depositional trends respectively, with the increment of mean granulometry of beach face, in the first case, and the reduction of mean grain size in the second. The beach face slope broadly followed the alongshore mean granulometry and sediment transport rates oscillations, but the results showed the influence of orthogonal and longitudinal process interaction on determining the behavior of the variable along the beaches systems. In this sense, the results indicated increased influence of longshore sediment transport in the morphodynamic behavior of the beach profile in the beach sectors with less exposure, where the predictive ability of omega was limited. In the more exposed beach sectors, the beach profile behavior is defined by greater interaction between orthogonal and longitudinal processes, resulting in greater adequacy of omega to predict the morphodynamic beach state. Taking into account the different studies undertaken in this thesis, the set of results showed the importance of longshore sediment transport to morphosedimentary beach process at different time and space scales. The examination of the adjustment between longshore sediment transport rates and slope beach face in other coastal sectors covering a more wide spectrum of wave energy will determine the extent of the relationship identified in this study, expanding the analytical horizon of morphodynamic beach processes and scientific imput to the coastal sediment management
