1,721,430 research outputs found
Enjoyment and appreciation as motivators for coping: Exploring the therapeutic effects of media messages on perceived threat.
Full text linkThis study explores how experience-based media messages featuring victims, survivors, and outperformers provide therapeutic benefits through the enjoyment and appreciation of the messages. Using the economic crisis as a context, our findings indicate that whereas distressed individuals were more likely to appreciate threat-related stories featuring victims and survivors over outperformers, nondistressed individuals were more likely to enjoy such stories featuring outperformers over victims and survivors. Appreciation and enjoyment of these threat-related stories predicted effective coping outcomes: positive reappraisal of the economic situation that also led to increased perceived control over the threat through positive affect. Health implications for enjoyment and appreciation of experience-based stories as motivators for coping outcomes are also discussed. © 2016 Jinhee Kim & Mina Tsay-Vogel.11Nssciscopu
Toward a Person X Situation Model of Selective Exposure: Repressors, Sensitizers, and Choice of Online News on Financial Crisis
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Hedonic and Eudaimonic Entertainment Consumption Experiences and Political Social Effects
No full text미디어 콘텐츠의 다양화, 혼종화로 인해 픽션과 논픽션 그리고 정보와 오락의 구분이 모호해지 고 있다. 이러한 흐름과 함께 본 연구에서는 정치사회적 내용이 주요 주제도 아니고 명시적으로 드러나지도 않는 엔터테인먼트 콘텐츠를 연구대상에 광범위하게 포함하여 해당 콘텐츠가 언제 그리고 어떻게 정치사회 효과를 발생시킬 수 있는지 살펴보았다. 최근 재미의 초점에서 벗어나 의미와 통찰의 경험을 강조한 엔터테인먼트 연구와 전통적 이중 정보처리를 이론적 배경으로 본 연구에서는 10명의 대학생을 심층 인터뷰하여 그들의 다양한 엔터테인먼트 소비 경험과 정치사 회 효과의 관계를 탐색했다. 인터뷰 결과, 기존의 정치 커뮤니케이션 영역에서 빈번하게 연구대상 으로 다루지 않았던 미국 드라마, 서바이벌 리얼리티쇼, 공부자극 쓴소리 동영상, 보디빌더들의 개인 채널, 게임 스트리밍 방송 등에서 정치사회적 주제가 포착되었다. 엔터테인먼트 콘텐츠 소비 를 통한 재미나 서스펜스 중심의 쾌락적 경험은 자동적 정보처리를 통해 특정 정치 이슈의 중요 성을 지각하도록 돕고 묘사된 가치나 규범을 저항없이 내재화시키는 것으로 보인다. 반면 의미, 통찰, 감동 등의 비(非)쾌락적 경험은 체계적 정보처리를 거쳐 정교화된 의견 형성, (주관적) 정치 사회 지식 습득, 공적 대화, 실제 정치 참여 등 규범적으로 좀 더 바람직할 수 있는 정치사회 효과를 촉진할 수 있는 가능성을 보였다. 엔터테인먼트 콘텐츠의 소비 경험으로 나타날 수 있는 정치사회 효과에서 우려할 만한 점을 추가로 논의했다. 마지막으로 후속 연구에서 엔터테인먼트 와 정치 커뮤니케이션 문헌의 이론적 통합으로 관련 주제를 탐색할 것을 제안했다.22Nkc
Judging a movie by its cover: A content analysis of sexual portrayals on video rental jackets
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Identification of lead small molecule inhibitors of glycogen synthase kinase-3 beta using a fragment-linking strategy
No full textGlycogen synthase kinase-3 beta (GSK3β) kinase serves as a promising therapeutic target for the treatment of various human diseases, such as diabetes, obesity, and Alzheimer's disease. In this study, we report lead GSK3β inhibitors identified using a fragment-linking strategy. Through the systematic exploration, a six-atom chain unit bearing the rigid double bond was found to be a suitable linker connecting two fragments, which enables favorable contacts with backbone groups of residues in the pockets. As a consequence, potent GSK3β inhibitor 9i was found with IC50 values of 19 nM. The binding mode analysis indicates that the activities of the inhibitors appear to be achieved by the establishment of multiple hydrogen bonds and hydrophobic interactions in the ATP-binding site of GSK3β. The good biochemical potencies and structural uniqueness of the inhibitors support consideration in the further study to optimize the biological activity. © 2016 Elsevier Ltd.1441sciescopu
sj-docx-1-mrx-10.1177_01979183231208429 - Supplemental material for Overcoming Social Interactions Stress During COVID-19 Lockdown: The Role of Individuals’ Mobility and Online Emotional Support
No full textSupplemental material, sj-docx-1-mrx-10.1177_01979183231208429 for Overcoming Social Interactions Stress During COVID-19 Lockdown: The Role of Individuals’ Mobility and Online Emotional Support by Matthieu Vétois, Katrin Sontag, Anita Manatschal, Nelida Planamente, Jinhee Kim, and Juan M. Falomir-Pichastor in International Migration Review</p
Application of Fragment-Based de Novo Design to the Discovery of Selective Picomolar Inhibitors of Glycogen Synthase Kinase-3 Beta
No full textA systematic fragment-based de novo design procedure was developed and applied to discover new potent and selective inhibitors of glycogen synthase kinase-3 beta (GSK3β). Candidate inhibitors were generated to simultaneously maximize the biochemical potency and the specificity for GSK3β through three design steps: identification of the optimal molecular fragments for the three sub-binding regions, design of proper linking moieties to connect the fragmental building blocks, and final scoring of the generated molecules. By virtue of modifying the ligand hydration free energy term in the scoring function using hybrid scaled particle theory and the extended solvent-contact model, we identified several GSK3β inhibitors with biochemical potencies ranging from low nanomolar to picomolar levels. Among them, the two most potent inhibitors (12 and 27) are anticipated to serve as promising starting points of drug discovery for various diseases caused by GSK3β because of the high specificity for the inhibition of GSK3β. © 2016 American Chemical Society4411sciescopu
Asymmetric C–H functionalization of cyclopropanes using an isoleucine-NH2 bidentate directing group
Full text linkThe systematic investigation of substrate-bound a-amino acid auxiliaries has resulted in catalytic
asymmetric C–H functionalization of cyclopropanes enabled by amino acid amides as chiral bidentate
directing groups. The use of an Ile-NH2 auxiliary embedded in the substrate provided excellent levels of
asymmetric induction (diastereomeric ratio of up to 72 : 1) in the Pd(II)-catalyzed b-methylene C(sp3)–H
bond activation of cyclopropanes and cross-coupling with aryl iodides.139401sciescopu
Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors
No full textThe c-KIT tyrosine kinase has emerged as a potential therapeutic target for an array of diseases. However, there exists a drug resistance that is caused by mutations in c-KIT; therefore, c-KIT remains as a clinical challenge due to limited effective treatment options for therapies. For example, the acquired activating point mutation D816V significantly impairs the efficacy of targeted cancer therapies. Understanding the mechanisms of drug resistance at the molecular level will aid in designing and developing particular inhibitors with the potential to overcome these resistance mutations. We undertake a structure-based de novo design of 7-azaindole as the molecular core using the modified scoring function. This approach led to an identification of new c-KIT inhibitors over 100-fold specific for the D816V mutant relative to the wild-type c-KIT with nanomolar inhibitory activity. More importantly, these compounds potently inhibit clinically relevant D816V mutations of c-KIT in biochemical and cellular studies.111111sciescopu
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