1,721,083 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Abstract 533: XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell
No full textAbstract
The X-linked inhibitor of apoptosis protein (XIAP) is a well-known potent apoptosis suppressor, and also participates in cancer cell biological behaviors, therefore attracting great attentions as a potential antineoplastic therapeutic target for past years. We found here that lacking of XIAP expression resulted in a remarkable suppression of EGFR expression, consequently leading to the deficient of anchorage-independent cell growth. Further study demonstrated that BIR domain of XIAP was crucial for regulating the EGFR translation by suppressing the transcription and expression of miR-200a. Mechanistic studies indicated that BIR domain activated the PP2A activity by decreasing the phosphorylation of PP2A at Tyr307 in its catalytic subunit, PP2A-C. Such activated PP2A prevented the deviant phosphorylation and activation of MAPK kinases/MAPKs, their downstream effector c-Jun, and in turn inhibiting transcription of c-Jun-regulated the miR-200a. Collectively, our study uncovered a novel function of BIR domain of XIAP in regulating the EGFR translation, providing significant insight into the understanding of the XIAP overexpression in the cancer development and progression, further offering a new theoretical support for using XIAP BIR domain and EGFR as targets for cancer therapy.
Citation Format: Xin Liao, Chao Huang, Jingxia Li, Chuanshu Huang. XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 533. doi:10.1158/1538-7445.AM2017-533</jats:p
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Abstract 3305: Autophagic induction through upregulation of sestrin-2 transcription and mRNA stability mediates the anticancer effect of new compound ChlA-F
No full textAbstract
ChlA-F is a novel conformation-derivative of Cheliensisin A (Chel A), which is a new styryl-lactone isolated from Chinese Herb Goniothalamus cheliensis Huand shows potent antitumor potential effect both in vitro and in vivo. However, the anticancer activity and its potential mechanisms underlying ChlA-F action have never been explored. In present study, we evaluated the potency of ChlA-F on anchorage-independent growth and its association with autophagic responses in human high grade invasive bladder cancer cells. We found that ChlA-F significantly inhibited anchorage-independent growth of human bladder cancer cells by induction of autophagy in a sestrin2(SESN2)-dependent Fashion. Our results revealed that ChlA-F treatment specifically induced SESN2 expression via increasing its both gene transcription and mRNA stability. On the one hand, ChlA-F treatment markedly attenuated Dicer protein abundance, and in turn abolished miR-27a maturation and further relieved miR-27a directly binding to SESN2 mRNA 3’UTR, thereby promoting SESN2 mRNA stabilization. On the other hand,ChlA-F treatment promoted Sp1 abundance and consequently mediated SESN2 transcription. Moreover, either knockdown of Sp-1 or ectopic expression of miR-27a could abolish the autophagic response and reversed the inhibition of anchorage-independent growth in human bladder cancer cells. These results demonstrate that anticancer effect of ChlA-F is mediated by its activating autophagic pathway through promoting both SESN2 mRNA transcription and stabilization,which offers novel insights into the anticancer effect of ChlA-F on bladder cancer and provides a therapeutic alternative against human bladder cancer.
Citation Format: Xiaohui Hua, Chuanshu Huang, Xueru Wu, Jingxia Li. Autophagic induction through upregulation of sestrin-2 transcription and mRNA stability mediates the anticancer effect of new compound ChlA-F [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3305. doi:10.1158/1538-7445.AM2017-3305</jats:p
Abstract 1898: MEG3 as a competing endogenous RNA binds with miR-27a to promote PHLPP2 protein translation, and consequently impairs bladder cancer invasion
No full textAbstract
Muscle invasion and metastasis of bladder cancer dramatically decrease survival rate, compared to 77% of 5 year survival rate of all bladder cancer, metastasis bladder cancer is only 5%. This truth implies that one of the therapeutic kernels of bladder cancer is to decrease, even block, its invasiveness. In the current study, we find that MEG3 is significantly downregulate in human muscle-invasive bladder cancer tissues compared with non-muscle invasive tissues. We also demonstrate the MEG3 strongly inhibits human bladder cancer cell invasiveness by acting as a ceRNA. We find that MEG3 competes with PHLPP2 mRNA for miR-27a binding, which leads to a decreased miR-27a activity, and subsequently reducing the translation inhibition of miR-27a to PHLPP2. The upregulated PHLPP2 decreases the c-Jun phosphorylation at Ser63/73, and in turn inhibits the c-Myc transcription and its mediated invasiveness of the bladder cancer cells. This is the first demonstration that MEG3 inhibits the invasiveness of human bladder cancer cells via negative regulation of c-Myc as a ceRNA. These findings not only provides a novel insight into understanding the mechanisms behind the MEG3 inhibiting the cancer cell invasion, but also reveals a potential targets for invasive bladder cancer prevention and therapy.
Citation Format: Chao Huang, Xin Liao, Jingxia Li, Chuanshu Huang. MEG3 as a competing endogenous RNA binds with miR-27a to promote PHLPP2 protein translation, and consequently impairs bladder cancer invasion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1898. doi:10.1158/1538-7445.AM2017-1898</jats:p
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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