337 research outputs found
Identity in the novels of Marcio Veloz Maggiolo
No full text(in English): The aim of this diploma thesis is to analyse the Dominican identity in the works of the Dominican author Marcio Veloz Maggiolo. At first, the thesis briefly summarizes the evolution of the Dominican literature and mentions its most significant figures. Secondly, it deals with the evolution of the dominicaness from the colonial period up to the present and explains the reasons of the rooted antihaitianism. The second part consists of a detailed analysis of the novels The Diffuse Biography of Sombra Castañeda and The Accordion Man by Marcio Veloz Maggiolo, emphasizing the symbols of the official government's discourse, and also a more opened perspective of the dominicaness
Designs of Early Phase Cancer Trials with Drug Combinations
No full textWe discuss several innovative phase I and phase I--II designs for early phase cancer clinical trial with drug combinations focusing on continuous dose levels of both agents. For phase I trials with drug combinations, the main objective is to estimate the maximum tolerated dose (MTD) curve in the two-dimensional Cartesian plane. A parametric model is used to describe the relationship between the doses of the two agents and the probability of dose-limiting toxicity (DLT). Trial design proceeds using cohorts of two patients receiving doses according to univariate escalation with overdose control (EWOC) or continual reassessment method (CRM). At the end of the trial, the MTD is estimated as a function of Bayes estimates of the model parameters. Furthermore, we present the model where a fraction of DLTs can be attributed to one or both agents, and show how the parametric designs can be adapted to account for an unknown fraction of attributable DLTs. We also consider the inclusion of a binary baseline covariate to describe sub-groups with different frailty levels. In phase I--II trials, it may not be possible to evaluate efficacy in a short window of time. In this case, two-stage designs are frequently employed. First, a set of maximum tolerated dose combinations is selected. Next, the selected set is then tested for efficacy, sometimes in a different patient population than that used in the first stage. We discuss binary and time-to-event endpoints to identify dose combinations along the MTD curve with maximum probability of efficacy in the second stage
Systematic reviews with language restrictions and no author contact have lower overall credibility: a methodology study
No full textZhen Wang,1–3 Juan P Brito,4 Apostolos Tsapas,5 Marcio L Griebeler,4 Fares Alahdab,1,3 Mohammad Hassan Murad,1,3,61Robert D and Patricia E Kern Center for the Science of Health Care Delivery, 2Division of Health Care Policy and Research, Department of Health Sciences Research, 3Knowledge and Evaluation Research Unit, 4Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA; 5Aristotle University of Thessaloniki, Thessaloniki, Greece; 6Division of Preventive, Occupational and Aerospace Medicine, Mayo Clinic, Rochester, MN, USABackground: High-quality systematic reviews (SRs) require rigorous approaches to identify, appraise, select, and synthesize research evidence relevant to a specific question. In this study, we evaluated the association between two steps in the conduct of an SR – restricting the search to English, and author contact for missing data – and the overall credibility of a SR.Methods: All SRs cited by the Endocrine Society's Clinical Practice Guidelines published from October 2006 through January 2012 were included. The main outcome was the overall A Measurement Tool to Assess Systematic Reviews (AMSTAR) score, as a surrogate of SR credibility. Nonparametric Kruskal–Wallis tests and multivariable linear regression models were used to investigate the association between language restriction, author contact for missing data, and the overall AMSTAR score.Results: In all, 69 SRs were included in the analysis. Only 31 SRs (45%) reported searching non-English literature, with an average AMSTAR score of 7.90 (standard deviation [SD] =1.64). SRs that reported language restriction received significantly lower AMSTAR scores (mean =5.25, SD =2.32) (P<0.001). Only 30 SRs (43%) reported contacting authors for missing data, and these received, on average, 2.59 more AMSTAR points (SD =1.95) than those who did not (P<0.001). In multivariable analyses, AMSTAR score was significantly correlated with language restriction (beta =-1.31, 95% confidence interval [CI]: -2.62, -0.01, P=0.05) and author contact for missing data (beta =2.16, 95% CI: 0.91, 3.41, P=0.001). However, after adjusting for compliance with reporting guidelines, language restriction was no longer significantly associated with the AMSTAR score.Conclusion: Fewer than half of the SRs conducted to support the clinical practice guidelines we examined reported contacting study authors or searched non–English literature. SRs that did not conduct these two steps had lower quality scores, suggesting the importance of these two steps for overall SR credibility.Keywords: evidence-based medicine, research design, validity, quality of evidenc
Phylogenetic diversity and the structure of host-epiphyte interactions
No full textThis repository contains code, and data used in the paper "Phylogenetic diversity and the structure of host-epiphyte interactions!", by Marcio R. Pie, Fernanda S. Caron, Sven P. Batke, Johan Reyes-Chávez, Thom Dallimore et al. Use the following link: https://github.com/fernandacaron/epi_evo
Melhoria da Atenção à Saúde de Usuários com Hipertensão Arterial Sistêmica e/ou Diabetes Mellitus na UBS/ESF: Luiz Nicoletti, São Marcos /RS.
No full textA Organização Mundial de Saúde recentemente divulgou dados referentes à prevalência e estimativas de crescimento mundial da Hipertensão Arterial Sistémica (HAS) e Diabetes Mellitus (DM) para os próximos anos. O Brasil ocupa o sexto lugar mundial em números de casos de pessoas adultas com Diabetes. O mais importante é que, por ser a HAS e DM doenças em muitos casos assintomáticas, aproximadamente a metade dos indivíduos afetados efetivamente desconhecem a doença. As estimativas para os próximos 25 anos destas doenças são impressionantes. Isso seria mais ou menos assumir que populações precisarem de medicações, visitas regulares ao médico e de exames laboratoriais. Uma boa parte desta população necessitaria ainda de eventuais internações hospitalares por razoes ligadas ao surgimento de complicações crónicas relacionadas. Qual seria o impacto disto na qualidade de vida das pessoas e na estrutura de um sistema previdenciário já precário? Esta pergunta não deve ser respondida somente pelos médicos, mas por toda a sociedade.(SBHAS,2013 e SBDM,2013). Estas doenças: HAS e DM estão muito associadas porque possuem aspectos em comum como origem e fatores de riscos entre outros sendo sua relação bem estreita. (SBHAS,2013 e SBDM,2013). Esta proposta de projeto estabelece um cenário rico, já que pode fornecer informações fundamentais para a prática e planejamento da equipe. Os profissionais da Atenção Básica tem importância primordial nas estratégias de prevenção, diagnóstico, monitoriarizaçao e controle da HAS e DM. O princípio fundamental da prática centrada na pessoa e, consequentemente, envolver usuários e cuidadores, em nível individual e coletivo, na definição e implementação de estratégias de controle para HAS e DM. Nosso trabalho tem como objetivo elevar a qualidade de vida e atenção de pessoas com estas doenças
1º Scientific Symposium about Natural Resources
No full textThe 1º Scientific Symposium about Natural Resources (1º Simpósio Científico sobre Recursos Naturais - SCRN) has as theme “Natural environmental and products: an interdisciplinary view”, and the main aim was encourage discussion among graduation and postgraduate students, and researchers with different disciplinary views, about the exploration, conservation and monitoring of natural resources, bringing out the importance of multidisciplinary actions in research to a responsible regional development. The event was a promotion of the Postgraduation Program in Natural Resource (Programa de Pós-graduação em Recursos Naturais - PGRN) of the State University of Mato Grosso do Sul (Universidade Estadual de Mato Grosso do Sul - UEMS) and received financial supported by Foundation for Support the Development of Teaching, Science and Technology of Mato Grosso do Sul (Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul, Fundect). The event was organized in the following thematic scopes: 1) Applied materials development for natural resources; 2) Analytical methods and control for natural resources; 3) Valuation and characterization of natural environmental; 4) Environmental monitoring; 5) Natural products and derived from vegetal and animal origins; 6) Evaluation, systematic and chemistry ecology. In this special issue published in Orbital: The Electronic Journal of Chemistry the reader has a sample of the 250 works presented during four event days. To publish in this issue all participants were invited to submit a full paper following the journal Author Guidelines. Sandro Marcio Lima (UEMS) Chairman Claudia Andrea Lima Cardoso (UEMS) Guest Editor</em
Marketing digital para promocionar los servicios del Eco Hostal Mamita Helmita S.C.R.L, Lambayeque-2020
No full textLa presente investigación tiene como objetivo “Determinar la influencia del marketing
digital en la promoción de los servicios del Eco Hostal Mamita Helmita S.C.R.L
Lambayeque 2020”, el problema fue determinar de qué manera el marketing digital
influye en la promoción del Eco Hostal Mamita Helmita. En cuanto a materiales y
métodos, el tipo de investigación es básica, prospectiva, además es cuantitativa y
correlacional, así mismo, el diseño es no experimental de corte transversal. Para
poder demostrar la hipótesis de la investigación se realizaron encuestas a los clientes
teniendo encuesta a una muestra de 308 clientes seleccionados, que permitirá
seleccionar a las personas adecuadas en el hotel para encontrar la realidad de la
promoción del servicio y su impacto en las personas, ya que debido al consecutivo
consumo podrán darnos una idea más real de este. En la investigación se hizo uso
del programa SPSS v. 25, de la misma manera el uso de la hoja de cálculo Excel para
hallar los resultados. Con el resultado se pudo se pudo justificar el problema, los
resultados demostraron que no existe una relación entre las variables en estudio, ya
que la significancia es mayor a 0.05. Se concluye que, el nivel de calidad de servicio
es bajo equivalente al 31.7%, mientras que el nivel de satisfacción del cliente es medio
con el 63.3%TesisGestión empresarial y emprendimient
I reclutamenti pubblici dell'emergenza. C'è del marcio in Danimarca?
No full textL’autore si sofferma sulle recenti innovazioni della disciplina del reclutamento nel settore
pubblico collegate alla necessità di attuare il piano nazionale di ripresa e resilienza. In particolare,
l’autore mette in evidenza le principali criticità consistenti: in massicce assunzioni a tempo determinato,
con il conseguente sviluppo di forti pressioni per la futura stabilizzazione di tale personale; in
procedure selettive troppo semplificate da non garantire l’effettivo accertamento delle qualità dei
candidati; in tendenze verso un rafforzamento della fidelizzazione politica della dirigenza.The author focuses on recent innovations in the public sector recruitment discipline linked to
the need to implement the national recovery and resilience plan.
In particular, the author highlights the main critical issues, which consist of: massive temporary hires,
resulting in the development of strong pressures for the future stabilization of such personnel; overly
simplified selection procedures that do not guarantee the effective assessment of candidates’ qualities;
and trends toward strengthening the political loyalty of management
Ficção científica e progresso tecnológico: uma análise de distopias climáticas do século XX
No full textScience fiction has been one of the most popular genres in literature since its emergence in the
19th century. The genre sought to look at the future, imagining new technological advances,
that then seemed unlimited, which brought it closer to the literature of utopia and dystopia.
After the end of World War II and the explosion of the atomic bomb, optimism in a world
guided by science diminishes considerably and dystopias considered the very end of civilization
through the apocalyptic and post-apocalyptic subgenres. The nuclear cataclysm remained
popular in fictional works throughout the century, but in 1970s, a new threat proved to be just
as dangerous for human civilization: the environmental crises. The prognosis of a collapse
created a dystopian imagery as powerful as that of a nuclear war. It was also a threat to the
capitalist mode of production since external limits to economic growth are established. If the
atomic bomb showed the destructive potential of war technology, environmental crises call into
question the same technological artifacts that allowed the optimism in the 19th century. This
dissertation asks how works of dystopian fiction characterize environmental crises over the last
century. Therefore, climatic dystopias are the object of study, defined as: fictional works located
in the near or distant future that describe a worse society, according to the author, than that of
the moment and place in which it was written and that deal with ecological or environmental
issues such as the focus, or one of the focuses, of the dysfunctionality of their world. Its
objective is to investigate the different critical perceptions regarding technology in climatic
dystopias. To do so, it proposes to examine the history of the belief in anthropogenic climate
change, to compare the dystopian character of science fiction works throughout the 20th century
and to identify in these specific criticisms the technology, taking into account its historical and
artistic context. In the results, it is observed that: the opposition between civilization and nature
is a recurring theme in the works studied, when reflecting on alternative modes of existence
outside modern industrial society; The works proved to be useful for the study of the history of
environmental crises, by revealing characteristics of key moments of awareness regarding
these; And, finally, there is no linearity in their criticism of technological progress, but they all
manifest positions contrary to the capitalist way of life.Agência 1A ficção científica tem sido um dos gêneros mais populares da literatura desde o seu surgimento
no século XIX. O gênero busca então olhar para o futuro, imaginando novos avanços
tecnológicos que então pareciam ilimitados, o que o faz se aproximar da literatura de utopia e
distopia. Após o fim da Segunda Guerra Mundial e a explosão da bomba atômica, o otimismo
em um mundo guiado pela ciência diminui consideravelmente e as distopias consideram o
próprio fim da civilização através dos subgêneros apocalíptico e pós-apocalíptico. O cataclisma
nuclear permanece popular nas obras ficcionais ao longo de todo o século, mas a partir dos anos
70, uma nova ameaça se revela tão perigosa para a civilização humana quanto: as crises
ambientais. O prognóstico de um colapso cria um imaginário distópico tão poderoso quanto o
de uma guerra nuclear, sendo também uma ameaça ao modo de produção capitalista, uma vez
que limites externos ao crescimento econômico são estabelecidos. Se a bomba atômica
evidenciou o potencial destrutivo da tecnologia bélica, as crises ambientais colocam em questão
os mesmos artefatos tecnológicos que permitiram o otimismo do século XIX. Este trabalho se
pergunta como obras de ficção distópicas caracterizam as crises ambientais ao longo do último
século. Tem objeto de estudo, portanto, as distopias climáticas, definidas como: obras ficcionais
situadas em um futuro próximo ou distante que descrevam uma sociedade pior, de acordo com
o autor, do que a do momento e local em que foi escrita e que tratem de questões ecológicas ou
ambientais como o foco, ou um dos focos, da disfuncionalidade do seu mundo. Seu objetivo é
investigar as diferentes percepções críticas em relação a tecnologia em distopias climáticas.
Para fazê-lo, se propõe a examinar a história da difusão da crença nas mudanças climáticas
antropogênicas, comparar o caráter distópico de obras de ficção científica ao longo do século
XX e identificar nestas críticas específicas a tecnologia, levando em conta seu contexto
histórico e artístico. Em seus resultados, observa-se que: a oposição entre civilização e natureza
é um tema recorrente nas obras estudadas, ao refletir sobre modos alternativos de existência
fora da sociedade industrial moderna; As obras se mostraram úteis para o estudo da história das
crises ambientais, ao revelar características de momentos chave da conscientização quanto a
estas; E, por fim, não há uma linearidade na crítica que realizam quanto ao progresso
tecnológico, mas todas manifestam posições contrárias ao modo de vida capitalista
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