368 research outputs found
A sensitive fluorescent probe for the polar solvation dynamics at protein–surfactant interfaces
No full textRelaxation dynamics at the surface of biologically important macromolecules is important taking into account their functionality in molecular recognition.</p
Synthesis of Ether-Linked Oligoribo- and Xylonucleosides from 3,5′-Ether-Linked Pseudosaccharides
No full textFirst examples of di- and trinucleosides with ribose and
xylose stereochemistry having internucleoside ether linkage
were synthesized from 3,5′-ether-linked pseudosaccharides.
The synthetic protocol involved removal of 1,2-isopropylidene
protecting groups from the pseudosaccharides followed
by acetylation and a subsequent Vorbru¨ggen transglycosylation
with uracil and N-benzoylaminopurine. The synthetic
strategy is potentially important for the development of RNA
analogues with internucleoside ether linkage
Pricing Derivatives: The Financial Concepts Underlying the Mathematics of Pricing Derivatives
No full textA fresh, fundamentals-based approach for accurate derivative pricing
Pricing Derivatives presents a specialized approach to accurately pricing derivatives by stressing the conceptual foundations underlying the mathematics. Noted mathematics professor and investing consultant Ambar Sengupta provides a sound understanding of the essential topics of derivative pricing and outlines methodologies for arriving at exact pricing formulas based on the fundamental relationship between price and probability.
Short, to-the-point chapters present original ideas and approaches for pricing derivative products, supplying professional money managers and institutional investors with the foundation they need to: Integrate both the theoretical and mathematical foundations of pricing derivatives Establish optimal prices in terms of the no-arbitrage principle Derive model-independent pricing formulas for options, futures, forwards, and other key derivatives
Experience has shown that derivative traders must focus on conceptual, as opposed to trading, issues if they are to improve trading accuracy and profitability. Pricing Derivatives presents conceptually sound approaches for pricing derivatives and shows how to use them to compute specific pricing formulas.
Pricing Derivatives unveils a fundamentally clear-cut approach to accurate derivative pricing. Based upon author Ambar Sengupta\u27s years of consulting experience working with derivatives traders to hone their trading performance, it steers around the mechanics of popular financial models to focus on the conceptual foundations and underlying mathematics of pricing derivatives as well as other financial instruments.
Exploring the relationshipbetween price and probability, Pricing Derivatives demonstrates methods for determining model-independent pricing formulas and applying them to specific market models for more distinct and applicable pricing formulas.https://repository.lsu.edu/facultybooks/1593/thumbnail.jp
Assessment of dopaminergic neuron degeneration in a C. elegans model of Parkinson's disease
No full textTransgenic Caenorhabditis elegans that expresses the full-length wild-type human α-synuclein in dopaminergic neurons provides a well-established Parkinson's disease (PD) nematode model. Here, we present a detailed protocol to monitor and dissect the molecular underpinnings of age-associated neurodegeneration using this PD nematode model. This protocol includes preparation of nematode growth media and bacterial food sources, as well as procedures for nematode growth, synchronization, and treatment. We then describe procedures to assess dopaminergic neuronal death in vivo using fluorescence imaging. For complete details on the use and execution of this protocol, please refer to SenGupta et al. (2021). © 2022 The Author(s
Financial Management of Globalization of Developing Countries
No full texthuman development, economic growth, globalization, inequality, poverty
Free vibration analysis of composite right angle triangular plate using a shear flexible element
No full text© 2003 SAGE Publications A high precision triangular plate bending element proposed by the second author of this paper has been upgraded for the free vibration analysis of laminated composite right angle triangular plates. The effect of shear deformation has been incorporated. An efficient mass lumping scheme with rotary inertia has been recommended. Numerical examples of composite triangular plates having different thickness ratios, side ratios, fibre-orientations, number of layers and boundary conditions have been solved by this element. For validation of the present formulation and element few results on isotropic and orthotropic plates have been compared with those obtained from literatures. The results on composite plates have been presented as new results. S. Haldar, D. Sengupta, and A. H. Sheik
Dataset to accompany "Deposition of brown carbon onto snow: changes of snow optical and radiative properties" by Beres et al., 2020
No full textThis dataset, organized in an Excel spreadsheet, accompanies:
Beres, N. D., Sengupta, D., Samburova, V., Khlystov, A. Y., and Moosmüller, H.: Deposition of brown carbon onto snow: changes in snow optical and radiative properties, Atmos. Chem. Phys., 20, 6095–6114, https://doi.org/10.5194/acp-20-6095-2020, 2020.
Each tab of the spreadsheet represents data presented in Tables and Figures of the manuscript, which allows for the replication of the figure or for use in calculations presented throughout the manuscript.
Any questions or comments should be forwarded to the corresponding author
MICROWAVE SPECTRUM AND MOLECULAR STRUCTURE OF CIS-1,2-DIFLUOROCYCLOPROPANE
No full text S.K. Sengupta and V.W. Laurie, Paper TGS, 32nd Symposium on Molecular Spectroscopy, Columbus, Ohio (1977).Author Institution: Department of Chemistry, Oberlin College; Department of Chemistry, Rensselaer Polytechnic Institute; Department of Chemistry, Temple UniversityThe microwave spectrum of a carbon-13 isotope of cis-1,2-difluorocyclopropane,, has been assigned in natural abundance. The normal and deuterium isotopic rotational constants reported were combined with the carbon-13 data to partially determine the molecular structure. The parameters are and . These structural parameters will be compared to the trans isomer of 1,2-difluorocyclopropane as well as to related geometrical pairs of fluorinated three-membered rings. The results will also be discussed in terms of recent theoretical studies of these ring systems
Bis- and Trisuracil Nucleosides with Nucleobases Anchored to 11-, 12-, and 16-Membered Macrocyclic Scaffolds: Synthesis and Aggregation Study
No full textBis- and trisuracil nucleosides, in which the nucleobases are anchored to isoxazoline ring-fused 11-, 12-,
and 16-membered macrooxacycles, were synthesized by nucleosidation of 1,2-isopropylidenefuranose
ring-fused macrocycles. The nucleosides exhibited spherical and fiber-like morphologies in water. In
one case, the morphology was significantly altered by complexation with an adenine nucleoside via
complementary base pairing
“Eyes on the Street”: Estimating Natural Surveillance Along Amsterdam’s City Streets Using Street-Level Imagery
No full textNeighborhood safety and its perception are important determinants of citizens’ health and well-being. Contemporary urban design guidelines often advocate urban forms that encourage natural surveillance or “eyes on the street” to promote community safety. However, assessing a neighborhood’s level of natural surveillance is challenging due to its subjective nature and a lack of relevant data. We propose a method for measuring natural surveillance at scale by employing a combination of street-level imagery and computer vision techniques. We detect windows on building facades and calculate sightlines from the street level and surrounding buildings across forty neighborhoods in Amsterdam, the Netherlands. By correlating our measurements with the city’s Safety Index, we also validate how our method can be used as an estimator of neighborhood safety. We show how perceived safety varies with window level and building distance from the street, and we find a non-linear relationship between natural surveillance and (perceived) safety.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Human-Centred Artificial IntelligenceInternet of Thing
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