533 research outputs found
James's Turn of the Screw
No full text[sound recording] / John Smith. Hardy's Tess of the d'Urbervilles by J.J. Coyle.; 1 sound cassette (60 minutes); Broadcast on CFCY Radio, Charlottetown, December 16 & 20, 1971.; Hardy's Tess of the d'Urberville
Book review: how to speak money by John Lanchester
No full textJohn Lanchester, the bestselling author of Capital and Whoops!, aims to decode the global language of money for all of us, in an amusing and jargon-free read. Diane Coyle finds this is a very entertaining read and a clear guide to the kind of economics spoken in the financial markets and the media. Those who already speak the language would do well to read the initial essay and reflect on it, and in particular on what normal people hear when they are using the jargon
Holography: art in space of technology
No full textContents: Preface / Rodney Wilson -- Foreword / Will Bell -- 1. Introduction. Technology and the (trans)formation of culture / Philip Hayward -- 2. How intimate can art and technology really be?: a survey of the art and technology movement of the sixties / Marga Bijvoet -- 3. From abstraction to simulation: notes on the history of computer imaging / Andy Darley -- 4. Holography - art in the space of technology: Margaret Benyon, Paula Dawson and the development of holographic arts practice / Rebecca Coyle -- 5. The architecsonic object: stereo sound, cinema and colors / Philip Brophy -- 6. Scratch and after: edit suite technology and the determination of style in video art / George Barber -- 7. Industrial light and magic: style, technology and special effects in the music video and music television / Philip Hayward -- 8. Power, access and ingenuity: electronic imaging technologies and contemporary visual art / Jeremy Welsh -- 9. Art byting the dust: some considerations on time, economy and cultural practices of postmodernity / Tony Fry -- 10. A new day for music? Digital technologies in contemporary music-making / Alan Durant -- 11. Digitisation and the living death of photography / Anne-Marie Willis -- 12. Negotiating presence: performance and new technologies / Andrew Murphie -- 13. Metamedia and cyberspace: advanced computers and the future of art / Paul Brown
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Remains
No full text'Remains' is a text composed by Annabel Frearson using the last words from the remaining books of a recently deceased artist. It was performed by the author at the launch event for the publication of Issue 2 of '...Or maybe it's the same for everyone' with contributing artists: Martin Westwood, Annabel Frearson, Patrick Coyle and Lizzy Kane.
A launch event was held with performances by the authors at Cafe Oto, London 6 May 2014
Fundamental studies towards the fabrication of electroactive monolithic stationary phases in microfluidic channels
No full textThe long term goal of this project is to develop a monolithic stationary phase which utilises an electroactive polymer combining the advantages of EMLC, monolithic technology and microfluidic separation, thus creating an electroactive monolithic microchip (EMμ). In this thesis, fundamental studies towards the fabrication of EMμ are presented, i.e. integration of an electrochemical cell into a microfluidic chip, colloidal crystallization in microfluidic channels and PANI growth through a colloidal crystal template. Polyaniline was selected as the electroactive material for the fabrication of the monolithic stationary phase as its use for EMLC had already been demonstrated. Colloidal crystals have been used to microstructure materials and the inverse opal structure comprises pore sizes of the order of what was needed for EMμ; therefore electropolymerization of aniline through a polystyrene colloidal crystal template strategy was chosen. Two alternative chip designs, CD1 and CD2, were investigated for this thesis. Their applicability for EMμ was assessed in terms of their flow velocity profile using computational fluid dynamic, colloidal crystallization feasibility and electrochemical behavior using ferricyanide electrochemistry. The integration of a fully operational three-electrode electrochemical cell within a microfluidic channel and its use for polyaniline electropolymerization was demonstrated, and self-assembly of the sacrificial polystyrene template in these channels was shown. Polyaniline microstructure morphology exhibited a dependence on the surfactant concentration present in the polystyrene suspension. Finally, electrochemical switching of conducting polymer within microfluidic channels was assessed by studying polypyrrole switching by atomic force microscopy (AFM). Pore swelling and contraction was observed on application of a potential, demonstrating that the monolith properties could be dynamically controlled. It was found that volume increase in the polymer could be responsible for a deformation of flow through pores due to physical confinement of the polymer
Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4
No full textBackground: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate cyclin D or cyclin E partners to form kinase-active holoenzymes. Deregulation of Cdk4 is widespread in human cancer, CDK4 gene knockout is highly protective against chemical and oncogene-mediated epithelial carcinogenesis, despite the continued presence of CDK2 and CDK6; and overexpresssion of Cdk4 promotes skin carcinogenesis. Surprisingly, however, Cdk4 kinase inhibitors have not yet fulfilled their expectation as 'blockbuster' anticancer agents. Resistance to inhibition of Cdk4 kinase in some cases could potentially be due to a non-kinase activity, as recently reported with epidermal growth factor receptor. Results: a search for a potential functional site of non-kinase activity present in Cdk4 but not Cdk2 or Cdk6 revealed a previously-unidentified loop on the outside of the C'-terminal non-kinase domain of Cdk4, containing a central amino-acid sequence, Pro-Arg-Gly-Pro-Arg-Pro (PRGPRP). An isolated hexapeptide with this sequence and its cyclic amphiphilic congeners are selectively lethal at high doses to a wide range of human cancer cell lines whilst sparing normal diploid keratinocytes and fibroblasts. Treated cancer cells do not exhibit the wide variability of dose response typically seen with other anticancer agents. Cancer cell killing by PRGPRP, in a cyclic amphiphilic cassette, requires cells to be in cycle but does not perturb cell cycle distribution and is accompanied by altered relative Cdk4/Cdk1 expression and selective decrease in ATP levels. Morphological features of apoptosis are absent and cancer cell death does not appear to involve autophagy. Conclusion: these findings suggest a potential new paradigm for the development of broad-spectrum cancer specific therapeutics with a companion diagnostic biomarker and a putative functional site for kinase-unrelated activities of Cdk4
Decision Frameworks for Assessing Cost-Effectiveness Given Previous Nonoptimal Decisions
No full textIntroduction:
Economic evaluations identify the best course of action by a decision maker with respect to the level of health within the overall population. Traditionally, they identify 1 optimal treatment choice. In many jurisdictions, multiple technologies can be covered for the same heterogeneous patient population, which limits the applicability of this framework for directly determining whether a new technology should be covered. This article explores the impact of different decision frameworks within this context.
Methods:
Three alternate decision frameworks were considered: the traditional normative framework in which only the optimal technology will be covered (normative); a commonly adopted framework in which the new technology is recommended for reimbursement only if it is optimal, with coverage of other technologies remaining as before (current); and a framework that assesses specifically whether coverage of the new technology is optimal, incorporating previous reimbursement decisions and the market share of current technologies (positivist). The implications of the frameworks were assessed using a simulated probabilistic Markov model for a chronic progressive condition.
Results:
Results illustrate how the different frameworks can lead to different reimbursement recommendations. This in turn produces differences in population health effects and the resultant price reductions required for covering the new technology.
Conclusion:
By covering only the optimal treatment option, decision makers can maximize the level of health across a population. If decision makers are unwilling to defund technologies, however, the second best option of adopting the positivist framework has the greatest relevance with respect to deciding whether a new technology should be covered.The authors received no financial support for the research, authorship, and/or publication of this article
Osteopontin as a regulator of leukemia inhibitory factor mRNA levels in the AtT-20 mouse pituitary cell line
No full textThe highly phosphorylated glycoprotein Osteopontin (OPN) is a multifaceted protein with a diversity of roles in many immunological processes, and has recently been found to have a significant role in the Hypothalamus-Pituitary-Adrenal (HPA) axis. Its role was discovered when unstressed OPN-knockout mice were found to have abnormally high basal corticosterone levels, which is the hormone typically elevated following stress induction of the HPA axis. Another protein rigorously studied and repeatedly identified in the successful functioning of the HPA axis is Leukemia Inhibitory Factor (LIF). I propose that OPN may possess a regulatory role in the expression of LIF, with the absence of OPN leading to a greater abundance of LIF mRNA, and consequently, over-production of corticosterone in non-stressful situations. Using the mouse anterior pituitary cell-line AtT-20, a common and highly useful model in HPA axis research, I have found evidence that treatment of these cells with OPN partially inhibits the expression of LIF mRNA. The dose-dependency of this inhibition appears to behave as either positive or negative depending on the cellular density of the culture treated with OPN. Should OPN turn out to be a regulator of LIF mRNA expression, then absence of OPN may lead to an over-abundance of LIF, therefore affecting the expression of several proteins downstream of LIF that potently stimulate corticosterone production, such as the cholesterol transport protein StAR. It may turn out that OPN has an especially significant and indispensable role in the HPA axis via regulation of LIF mRNA levels.M.S.Includes bibliographical referencesby Luke Coyl
Developing compact and innovative dual-band thermal imagers using multi-layer diffractive optical elements
No full textInfrared (IR) remote sensing offers a huge range of applications, mostly addressing make-or-break issues of our century (wildfires, irrigation monitoring, etc.). Multispectral spaceborne instruments require bulky optical systems designed for a specific scientific goal and have very low revisit time. Thereby, constellations of small satellites embarking compact dual-band IR imagers are very promising solutions. We study a dual-band IR diffractive element called multilayer diffractive optical elements (MLDOE). It replaces classical diffractive lenses (DOEs) that cannot operate simultaneously in two distinct wavebands. An MLDOE design is studied using the rigorous finite difference time domain (FDTD) method. Its performance at the ”best” focal plane is deduced using free-space Fourier optics wave propagation. The presented MLDOE design has over 80% Strehl ratio in both bands, outperforming classical DOEs. Its chromatic focal shift has a negative variation, in opposition to refractive lenses, allowing efficient and compact dual-band hybrid lenses.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Spaceborne Instrumentatio
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