1,756 research outputs found
The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function
No full textCo-author Johnna Doherty is a student in the Neuroscience program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School, and Jennifer MacDonald is in the MD/PhD program.After neuronal injury or death glial cells become reactive, exhibiting dramatic changes in morphology and patterns of gene expression and ultimately engulfing neuronal debris. Rapid clearance of degenerating neuronal material is thought to be crucial for suppression of inflammation and promotion of functional recovery. Here we demonstrate that Drosophila c-Jun N-terminal kinase (dJNK) signaling is a critical in vivo mediator of glial engulfment activity. In response to axotomy, we find glial dJNK signals through a cascade involving the upstream mitogen-activated protein kinase kinase kinases Slipper and Tak1, the mitogen-activated protein kinase kinase MKK4, and ultimately the Drosophila activator protein 1 (AP-1) transcriptional complex composed of Jra and Kayak to initiate glial phagocytosis of degenerating axons. Interestingly, loss of dJNK also blocked injury-induced upregulation of Draper levels in glia, and glial-specific overexpression of Draper was sufficient to rescue engulfment defects associated with loss of dJNK signaling. This work identifies that the dJNK pathway is a novel mediator of glial engulfment activity and a primary role for the glial Slipper/Tak1short right arrowMKK4short right arrowdJNKshort right arrowdAP-1 signaling cascade appears to be activation of draper expression after axon injury.Cell Death and Differentiation advance online publication, 26 April 2013; doi:10.1038/cdd.2013.30.MD/PhDNeuroscienc
A 26GHz Balun-First Three-Way Doherty PA in 40nm CMOS with 20.7 dBm Psat and 20dB Power Gain
No full textThis paper presents a 40nm CMOS mm-wave 3-way Doherty power amplifier (PA) suitable for 5G mm-wave transmitters. It features a bandwidth-enhanced technique using a compact single-supply balun-first 3-way Doherty combiner. The realized front-end with a core area of 0.77 mm2delivers a peak power/gain of more than 20 dBm/16 dB and a drain efficiency (DE) of better than 15 %/22 %/33 % at 9.5 dB/6 dB/0 dB power back-off across a 24-to-30 GHz band. At 26 GHz, it achieves an EVM/ACLR of -23.5 dB/-29.5 dBc for an 800MHz 64-OFDM signal with 9.8 dBm average output power and a 15 % average DE.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic
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Through the Lens of Color: An Interview with Gareth Doherty, Author of Paradoxes of Green: Landscapes of a City-State
No full textThis interview by Mark Tirpak with Gareth Doherty of Harvard University Graduate School of Design, focuses on his Paradoxes of Green: Landscapes of a City-State (University of California Press, 2017). With Paradoxes of Green (2017) and via the interview, Doherty recounts some of the findings of his ethnographic fieldwork in the Kingdom of Bahrain and describes tensions arising from differing conceptions of what ‘green’ means or signifies within this growing and predominantly arid region. An argument that Doherty makes in Paradoxes of Green (2017) is that color and form are interlinked, and that color deserves deeper consideration by policy-makers and other formal shapers of cities. The interview draws from Paradoxes of Green (2017) to discuss some of Doherty’s findings as well as his latest work on the intersections between landscape architecture and anthropology.Version of Recor
A Wideband Two-Way Digital Doherty Transmitter in 40nm CMOS
No full textA 40nm CMOS wideband digital Cartesian push-pull inverted Doherty operating in class-E is presented. Wideband Doherty operation is achieved over a 1.9-to-3GHz frequency band, using an off-chip power combining network. The fully digital transmitter (DTX) provides 25.3dBm peak power with a drain/DTX line-up efficiency (DE/SE) of 58.7%/44.9%, respectively, at 2.4GHz. When operated with a 160MHz 256-QAM OFDM signal, it achieves 46.1%/32.7% average DE/SE, with an ACLR and EVM better than −40.6dBc and −33.9dB, respectively, using a simple memory-less digital pre-distortion (DPD).Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic
Through the Lens of Color: An Interview with Gareth Doherty, Author of Paradoxes of Green: Landscapes of a City-State
No full textThis interview by Mark Tirpak with Gareth Doherty of Harvard University Graduate School of Design, focuses on his Paradoxes of Green: Landscapes of a City-State (University of California Press, 2017). With Paradoxes of Green (2017) and via the interview, Doherty recounts some of the findings of his ethnographic fieldwork in the Kingdom of Bahrain and describes tensions arising from differing conceptions of what ‘green’ means or signifies within this growing and predominantly arid region. An argument that Doherty makes in Paradoxes of Green (2017) is that color and form are interlinked, and that color deserves deeper consideration by policy-makers and other formal shapers of cities. The interview draws from Paradoxes of Green (2017) to discuss some of Doherty’s findings as well as his latest work on the intersections between landscape architecture and anthropology
Parallel Doherty RF Power Amplifier For WiMAX Applications
No full textabstract: This work covers the design and implementation of a Parallel Doherty RF Power Amplifier in a GaN HEMT process for medium power macro-cell (16W) base station applications. This work improves the key parameters of a Doherty Power Amplifier including the peak and back-off efficiency, operational instantaneous bandwidth and output power by proposing a Parallel Doherty amplifier architecture.
As there is a progression in the wireless communication systems from the first generation to the future 5G systems, there is ever increasing demand for higher data rates which means signals with higher peak-to-average power ratios (PAPR). The present modulation schemes require PAPRs close to 8-10dB. So, there is an urgent need to develop energy efficient power amplifiers that can transmit these high data rate signals.
The Doherty Power Amplifier (DPA) is the most common PA architecture in the cellular infrastructure, as it achieves reasonably high back-off power levels with good efficiency. This work advances the DPA architecture by proposing a Parallel Doherty Power Amplifier to broaden the PAs instantaneous bandwidth, designed with frequency range of operation for 2.45 – 2.70 GHz to support WiMAX applications and future broadband signals.Dissertation/ThesisMasters Thesis Electrical Engineering 201
Wideband Digital Intensive Doherty Concepts
No full textMany applications require wide bandwidth transmitters, but unfortunately, they usually have way less than 50% average drain efficiency for their modulated signals. This low efficiency is a significant drawback in all wireless applications, both for battery power devices and base stations. The Doherty radio frequency (RF) power amplifier architecture is widely used to enhance the average efficiency for modulated signals in base stations. Its popularity is due to its relatively cheap and simple hardware and its suitability to handle high-power wideband modulated signals. However, even Doherty amplifiers often have less than 50% average efficiency and are restricted in their RF bandwidth.This thesis reviews recent research on the Doherty power amplifier (DPA) topology and discusses possible power and bandwidth efficiency improvements. In the second part of the thesis, another topology is introduced, which also provides Doherty-like behavior. That topology is called a Pseudo Doherty Load Modulated Balanced Amplifier (PD-LMBA). The performance of PD-LMBA is compared with “conventional” DPAs. Circuit design examples of DPA and PD-LMBA are given. The thesis concludes with a PD-LMBA prototype design, which appears to be very promising in its wideband performance.Electrical Engineering | Microelectronic
Helping children think: Gaze aversion and teaching
No full textLooking away from an interlocutor's face during demanding cognitive activity can help adults answer challenging arithmetic and verbal-reasoning questions (Glenberg, Schroeder, & Robertson, 1998). However, such `gaze aversion' (GA) is poorly applied by 5-year-old school children (Doherty-Sneddon, Bruce, Bonner, Longbotham, & Doyle, 2002). In Experiment 1 we trained ten 5-year-old children to use GA while thinking about answers to questions. This trained group performed significantly better on challenging questions compared with 10 controls given no GA training. In Experiment 2 we found significant and monotonic age-related increments in spontaneous use of GA across three cohorts of ten 5-year-old school children (mean ages: 5;02, 5;06 and 5;08). Teaching and encouraging GA during challenging cognitive activity promises to be invaluable in promoting learning, particularly during early primary years
A Highly Linear Wideband Polar Class-E CMOS Digital Doherty Power Amplifier
No full textThis article presents the first application of a digital-intensive intrinsically linear digitally controlled class-E technique in a Doherty configuration. By careful nonlinear segmentation and multiphase RF-clocking along with overdrive-voltage control and automatic duty-cycle correction, it is shown that even the nonlinearities related to Doherty operation can be fully handled by the underlying design such that digital predistorion (DPD) can be, in principle, omitted. The nonlinearity behavior of the whole digital Doherty power amplifier (PA) is analyzed, and closed-form equations are given to predict the AM-AM and AM-phase modulation (PM) curves. In addition, time/phase mismatch between the peak and main branches and the AM and PM signals is accurately compensated. In order to achieve the maximum intrinsic linearity, two separate chips with the same architecture, but different design parameters, are fabricated as the main and peak amplifiers in 40-nm bulk CMOS. To achieve a large RF bandwidth and high passive combiner efficiency, a differential low-loss, wideband Marchand balun-based Doherty power combiner, implemented using reentrant coupled lines with independent second-harmonic control is proposed, and together with the matching network is fabricated on a two-layer PCB. The measured peak/6-dB power backoff P OUT, drain efficiency/power-added efficiency at 2.4 GHz are 17.5 dBm/12.2 dBm, 57%/52% and 36%/25% with VDD main/peak = 0.6 V/0.7 V. Measured results without using DPD show -41-dBc adjacent channel power ratio (ACPR) and -36-dB error vector magnitude (EVM) for a 16-MHz OFDM signal at 2.5 GHz. By using DPD, the measured ACPR and EVM of a 16-MHz/32-MHz OFDM signals are -52 dBc/-48 dBc and -50 dB/-48 dB, respectively.Accepted author manuscriptElectronic
A 39 W Fully Digital Wideband Inverted Doherty Transmitter
No full textA high-power fully-digital Doherty transmitter (DDTX) is proposed. It features two segmented LDMOS output switch banks implemented in a custom V T -down-shifted LDMOS technology. A 40 nm CMOS controller digitally activates the individual LDMOS gate segments of the output stage at RF speed. An inverted Doherty power combiner is proposed that features non-short circuited 2 nd harmonic conditions for the main and peak switch banks to boost the RF bandwidth. To guarantee smooth output power and efficiency vs. frequency, a 2 nd harmonic trap is introduced in the power combiner, yielding an RF bandwidth of > 400 MHz. The realized demonstrator can achieve over 39 W peak output power. Its highest drain and system efficiencies, respectively 60 % and 57 %, were found at 34.2 W of output power, while in power back-off its peak drain and system efficiencies are 52 % and 48 % respectively. Over a 25 dB output range, the system efficiency is within 4 percent points of the drain efficiency.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic
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