2,726 research outputs found
T.R.H. Jenkins fonds, 1946-1960
No full textThomas Roland Harries (Rowly) Jenkins (1924-2020) was an engineer who worked at the English Electric Company in St. Catharines. He graduated from the University of Toronto in 1950 and was then accepted to the English Electric Company’s graduates’ training course that same year. Jenkins completed the two-year course in 1952 after advanced training with switchgear engineers. He remained with the company for several more years and was promoted to Manager of Circuit Breaker Engineering in 1956. Jenkins also served as President of the Niagara Group of Professional Engineers in 1955-56.
In 1908 the Canadian Crocker-Wheeler Company was established in St. Catharines. They produced small industrial motors that were sold under the names of Canadian Crocker-Wheeler and English Electric. The company later changed its name to the English Electric Company of Canada and produced a wider range of products including transformers, induction and synchronous motors, generators, switchboards and switching equipment, and more. The company continued to expand and by 1947 new buildings had been constructed and manufacturing facilities expanded. In 1945 Inglis acquired a controlling interest in the English Electric Company in St. Catharines, and in 1947 became a wholly owned subsidiary of the John Inglis Company. The depression in 1957-1958 caused a steep decline in business and the company was forced to shut down. In 1961 the operations moved to Scarborough.The fonds contains material acquired by T.R.H. Jenkins during the time that he was employed with the English Electric Company of Canada in St. Catharines. Materials include correspondence, photographs, reports, and a book about Inglis Canada
Meeting with the Hebrew author Elias Hurwitz
No full textWhite paper; handpainted; on the reverse of Luftwaffe uniform pattern. Digitized posters are related to the activities of Jewish displaced persons drawn from the Records of Displaced Persons Camps and Centers in Germany (RG 294.2) Italy (RG 294.3) and Austria (RG 294.4) held by YIVO Archives. Please consult the historical note for those record groups for further information.Digital ImageDigital finding aid available
Obituary announcement about author and labor activist Sh. Mendelson
No full textBrown paper; handpainted. Digitized posters are related to the activities of Jewish displaced persons drawn from the Records of Displaced Persons Camps and Centers in Germany (RG 294.2) Italy (RG 294.3) and Austria (RG 294.4) held by YIVO Archives. Please consult the historical note for those record groups for further information.Digital ImageDigital finding aid available
Rapid reversion from monomer to dimer regenerates the ultraviolet-B photoreceptor UV RESISTANCE LOCUS8 in intact arabidopsis plants
No full textArabidopsis (Arabidopsis thaliana) UV RESISTANCE LOCUS8 (UVR8) is a photoreceptor that specifically mediates photomorphogenic responses to ultraviolet (UV)-B in plants. UV-B photoreception induces the conversion of the UVR8 dimer into a monomer that interacts with the CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) protein to regulate gene expression. However, it is not known how the dimeric photoreceptor is regenerated in plants. Here, we show, by using inhibitors of protein synthesis and degradation via the proteasome, that the UVR8 dimer is not regenerated by rapid de novo synthesis following destruction of the monomer. Rather, regeneration occurs by reversion from the monomer to the dimer. However, regeneration of dimeric UVR8 in darkness following UV-B exposure occurs much more rapidly in vivo than in vitro with illuminated plant extracts or purified UVR8, indicating that rapid regeneration requires intact cells. Rapid dimer regeneration in vivo requires protein synthesis, the presence of a carboxyl-terminal 27-amino acid region of UVR8, and the presence of COP1, which is known to interact with the carboxyl-terminal region. However, none of these factors can account fully for the difference in regeneration kinetics in vivo and in vitro, indicating that additional proteins or processes are involved in UVR8 dimer regeneration in vivo
Sweeping has no effect on renormalized turbulent viscosity
No full textWe perform renormalization group analysis (RG) of the Navier-Stokes equation in the presence of constant mean velocity field , and show that the renormalized viscosity is unaffected by , thus negating the ``sweeping effect", proposed by Kraichnan [Phys. Fluids {\bf 7}, 1723 (1964)] using random Galilean invariance. Using direct numerical simulation, we show that the correlation functions for and differ from each other, but the renormalized viscosity for the two cases are the same. Our numerical results are consistent with the RG calculations
Modelling Sorsby’s Fundus Dystrophy using patient-derived iPSC-RPE
No full textPurpose : Sorsby’s fundus dystrophy (SFD) leads to bilateral loss of central vision and is caused by mutations in the gene TIMP3. The mechanisms by which TIMP3 mutations cause SFD are poorly understood. iPSC-retinal pigmented epithelial (RPE) cells were generated from SFD patients and controls (ctrl) and cultured on transwell inserts to develop a RPE cell model which was used to study effects of specific TIMP3 mutations on cellular structure and physiology.Methods : Human fibroblasts were isolated from SFD (TIMP3 S204C) and ctrl subject skin biopsies by explant migration and reprogrammed into iPSCs. These iPSC colonies were cultured in RPE differentiation medium for 4 weeks until sufficient pigmentation was achieved before being transferred to transwells. Transmission electron microscopy (TEM) was used to analyse morphological differences between SFD and ctrl RPE cells. Transepithelial electrical resistance (TEER) was used to measure RPE barrier integrity. To assess the ability of TIMP3 to inhibit MMP activity, protein lysates from SFD and ctrl RPE cells were tested in an EnzCheck collagenase assay.Results : iPSC-RPE cells were successfully derived from SFD and ctrl patients. TEM analysis revealed significant differences in RPE containing mutant TIMP3 with respect to cell height (SFD 10.3µm ±0.23 SEM, ctrl 13.23µm ±0.43 SEM, p<0.0001) and basal laminar area (SFD 6µm2 ± 0.446 SEM, ctrl 14µm2 ±0.65 SEM, p<0.0001). Striated sub RPE deposits were observed, consistent with long-spacing collagen. A significantly higher number of focal collagen deposits were seen per cell in ctrl-RPE compared to SFD-RPE (SFD 1.444 ±0.44 SEM, ctrl 3.286 ± 0.52 SEM, p<0.05). The number of melanosomes per cell was also significantly higher in ctrl-RPE compared to SFD-RPE (SFD 40.2 ±2.34 SEM, ctrl 57.54 ± 3.74 SEM, p<0.001). However, there was no difference in their basal/apical distribution. SFD-RPE cells showed significantly lower average TEER over 90 days in culture compared to ctrl-RPE (SFD1 161.1 ± 15.9 SEM, ctrl 499.4 ± 49.79 SEM, p<0.001). The enzyme assay showed TIMP3 S204C mutation does not significantly affect the ability of TIMP3 to inhibit collagenase.Conclusions : The S204C TIMP3 mutation reduces the barrier integrity of RPE cells and results in key morphological alterations to the RPE, including cell height, not previously described. However, our findings indicate that the S204C mutation does not affect TIMP3’s ability to inhibit MMP-9 activity
BONDING AND DYNAMICS OF CNRg AND CRg COMPLEXES
No full textAuthor Institution: Department of Chemistry, Emory University, Atlanta, GA 30322The van der Waals complexes of CN and C with rare gas atoms (Rg) are of interest from the perspectives of their bonding characteristics and predissociation dynamics. Matrix isolation data indicate that that the bonding ranges from a weak van der Waals interaction for the Ne complexes to incipient chemical bonding for Xe. The low-lying vibronic states of CN and C are interleaved, which facilitates electronic energy transfer. Consequently, electronic predissociation of CNRg and CRg complexes provides a useful means to examine the detailed dynamics of electronic energy transfer. Predissociation processes for CNRg complexes have been characterized using double resonance techniques. The final state distributions exhibit symmetry preferences that yield insights concerning the topologies of the relevant potential energy surfaces. In addition, bond energies can be deduced from the predissociation dynamics. Data for the binary complexes CNRg (Rg=Ne, Ar, Kr, and Xe) and CRg will be presented, along with theoretical analyses based on potential energy surfaces
René Géronimo Favaloro : pioneer of Cardiac Surgery
No full textDr. René G. Favaloro moved to the Cleveland Clinic in 1962 and proceeded to reshape the face of cardiac surgery as we knew it. Together with his colleagues at the Cleveland Clinic, Drs. Effler, Sones, Proudfit, Groves, Sheldon and countless others, he contributed to the double internal mammary arterymyocardial implantation by the Vineberg method, and by May 1967, he reconstructed the right coronary artery by the saphenous vein graft interposition. These landmark procedures paved the way for the aorto-coronary saphenous vein bypass graft in October 1967. Many similar breakthroughs ensued, with the application of the bypass technique to the left coronary artery, the combination of coronary artery bypass graft with left ventricular reconstruction and valve repair/replacement and finally, by December, a double bypass to the right coronary artery and anterior descending branch of the left coronary artery. In June, 1971, Dr. Favaloro decided to leave the Cleveland Clinic and return to Argentina where he created a medical centre, a teaching unit, a research department and finally an Institute of Cardiology and Cardiovascular Surgery. This was his greatest personal ambition. Over and above his brilliant mind and craft, Dr. Favaloro was a man of integrity, courage, honesty and humility, whose name will never cease to reverberate throughout the history of medicine.peer-reviewe
Child abuse registration, fetal growth, and preterm birth: a population based study
No full textObjectives: To study the relation of intra-uterine growth and gestational age with child protection registration in a 20 year whole population birth cohort.
Setting: West Sussex area of England.
Study design: Retrospective whole population birth cohort.
Outcomes: Child protection registration; individual categories of registration—sexual abuse, physical abuse, emotional abuse, and neglect.
Population and participants: 119 771 infants born in West Sussex between January 1983 and December 2001 with complete data including birth weight, gestational age, maternal age, and postcode.
Results: In all categories of registration a linear trend was noted such that the lower the birth weight z score the higher the likelihood of child protection registration. Similar trends were noted for gestational age. All these trends were robust to adjustment for maternal age and socioeconomic status.
Conclusions: The results of this study suggest that lower levels of fetal growth and shorter gestational duration are associated with increased likelihood of child protection registration in all categories including sexual abuse independent of maternal age or socioeconomic status. This study does not permit comment on whether poor fetal growth or preterm birth predispose to child abuse and neglect or the association arises because they share a common pathway
A non-classical synthetic strategy for organic mesocrystals
No full textMesocrystals are ordered nanoparticle superstructures, often with internal porosity, which receive much recent research interest in catalysis, energy storage, sensors, and biomedicine area. Understanding the mechanism of synthetic routes is essential for precise control of size and structure that affect the function of mesocrystals. The classical synthetic strategy of mesocrystal was formed via self-assembly of nanoparticles with a faceted inorganic core but a denser (or thicker) shell of organic molecules. However, the potential materials and synthetic handles still need to be explored to meet new applications. In this work, we develop a non-classical synthetic strategy for organic molecules, such as tetrakis (4-hydroxyphenyl) ethylene (TPE-4OH), tetrakis (4-bromophenyl) ethylene (TPE-4Br), and benzopinacole, to produce mesocrystals with composed of microrod arrays via co-solvent-induced crystal transformation. The aligned nanorods are grown epitaxially onto organic microplates, directed by small lattice mismatch between plates and rods. Thus, the present work offers general synthetic handle for establishing well-organized organic mesocrystals.Ministry of Education (MOE)Published versionThe author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the MOE of Singapore (RG 14/13 and RG 5/16), the National Natural Science Foundation of China (No. 21673117), recruitment Program of Global Experts, Jiangsu Provincial Foundation for Specially-Appointed Professor, start-up fund at Nanjing Tech University (39837102), SICAM Fellowship from Jiangsu National Synergetic Innovation Center for Advanced Materials, and Jiangsu Science and Technology Plan (Project No. BK20211258)
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