324,427 research outputs found
Engineering Multi-Layered Encapsulations for Combinatorial Stem Cell Biology
No full textElectrospray techniques have become established in the life sciences for uses
from cell encapsulation (Chang, 1964) to directed cell placement in more recent
times (Jayasinghe et al., 2006a). During electrostatic encapsulation a conducting
fluid in a needle connected to a high voltage power supply is charged and then
drawn towards a grounded electrode by an electric field resulting in spraying.
Cells and other materials can be encapsulated by suspending them in an alginate
solution and electrospraying directly into a solution containing of a crosslinking
agent, most commonly calcium chloride. This technique can be used to directly
process and encapsulate many different types of materials (Jayasinghe and
Townsend-Nicholson, 2006, Jayasinghe, 2007, Patel et al., 2008). This research
adapts this technology further and progresses it by creating structures with
multiple layers over an extended period with fluorescent markers contained
within the layers, which are created through chemical adsorption. This allows
the encoding information for the use in combinatorial stem cell biology where
instead of individual experiments a large number of permutations are explored
simultaneously. The research covers various parameters governing the
encapsulation and layering processes as well as the biological functionality and
integration as a tool for combinatorial stem cell cultures. The novel
encapsulation and encoding technique presented here has a number of
advantages over the currently available technology and has been filed as patent
PCT/EP2010/006459
Santhanadeepaya: Heritage catholic churches of the Kalpitiya peninsula
No full textThe book is a historical and architectural survey of the Catholic churches of the Kalpitiya peninsula which is located in the North-Western province of Sri Lanka. While analysing in detail the historical evolution of art and architecture of the centre of devotion of the peninsula; the St Anne’s Shrine, Talawila, it also traces the diversity of design in other churches of the peninsula. The book also narrates the often turbulent history of the unfolding and institutional growth of Catholicism in the Kalpitiya peninsula
Recent advances in the synthesis of naturally occurring tetronic acids
No full textDuring the last decades the interest towards natural products containing the tetronic acid moiety augmented significantly, due to their challenging structures and to the wide range of biological activities they display. This increasing enthusiasm has led to noteworthy advances in the development of innovative methodologies for the construction of the butenolide nucleus. This review provides an overview of the progress in the synthesis of tetronic acid as a structural key motif of natural compounds, covering the last 15 years. Herein, the most representative synthetic pathways towards structurally diverse natural tetronic acids are grouped according to the strategy followed. The first part describes the functionalization of a preformed tetronic acid core by intermolecular reactions (cross-coupling reactions, nucleophilic substitution, multicomponent reactions) whereas the second part deals with intramolecular approaches (Dieckmann, cycloaddition or ring expansion reactions) to construct the heterocyclic core. This rational subcategorization allowed us to make some considerations about the best approaches for the synthesis of specific substrates, including modern intriguing methodologies such as microwave irradiation, solid phase anchoring, bio-transformations and continuous flow processes
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Energy poverty in Sri Lanka
No full textUnderstanding energy poverty is fundamental to any efforts to alleviate it. This paper, using the latest (2016) Sri Lankan Household Income and Expenditure survey data, examines the incidence, intensity, inequality, and determinants of energy poverty in Sri Lanka, by constructing the Multidimensional Energy Poverty Index (MEPI). The MEPI is calculated using a set of seven key indicators representing multiple dimensions of energy and assigning weights by using the Principal Component Analysis (PCA). Sri Lankan households, on average, are experiencing a moderate level of energy poverty (with MEPI of 0.431) where the lack of access to modern cooking fuel is the largest contributor to energy poverty. Results of this study revealed notable differences in energy poverty by gender, age, ethnicity, and income group of the head of the household and by sub-national location of the household. Significant differences in inequality in energy poverty were also observed by sub-national location and income. While energy-poor households are not necessarily always income-poor, income and other socio-demographic and geographical factors are strongly associated with energy poverty in Sri Lanka. The findings of this study raise alarms for the possible adverse implications on health and education attainment of the energy-poor. Overall, the results provide valuable policy insights into one of the most neglected dimensions of the post-war development policy agenda in Sri Lanka, in particular, and other developing countries, in general.Full Tex
Flow behaviour of dielectric liquids in an electric field
No full textA family of 10 silicone oils with electrical conductivity similar to 10(-13) S m(-1) (a regime hitherto systematically unexplored) and viscosities ranging from 1 to 2000mPas have been Subjected to an electrical field of up to 1.5kV mm(-1) during flow from a needle. The flow behaviour of these liquids is investigated experimentally in the flow rate regime 10(-8)-10(-12) m(3) s(-1) and we analyse the results using the Ohnesorge number. Due to the low electrical conductivity and high electrical relaxation time of the silicone oils, only unsteady transient jets were found. The onset of this type of jetting has been defined using current measurements and, in contrast to conducting liquids, the non-dimensional jet diameter increases with increase in Ohnesorge number. The time elapsed between the start and finish of jetting increases with increasing Ohnesorge number
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author's address:
No full textCan archives of audiovisual TV interviews be used to make authors more visible to students, and thereby reduce the learning gap between native and non-native language speakers in college classes? We examined students in a college course who learned about one scholar's ideas through watching an audiovisual TV interview (i.e., visible author format) and about another scholar's ideas through reading a formal text description (i.e., invisible author format). For the invisible author, native language speakers scored significantly higher than the non-native language speakers on a corresponding exam question (i.e., a cognitive measure), generated more words on the exam question (i.e., a motivational measure), and mentioned the author's name more often in answering the exam question (i.e., an affective measure). For the visible author, the groups did not differ on any of these measures. These findings provide evidence for the idea that making the author visible through audiovisual TV interviews can eliminate the learning gap between native and non-native language speakers. 3 Universities around the world serve students who are non-native speakers of th
- …
