21 research outputs found
Computational study to assess arterial function recovery in PAD patients with micro-vascular insufficiency and integration of smart screening technology using skin patch biosensor to predict the severity of peripheral artery disease
No full textThesis (M.S.)--Wichita State University, College of Engineering, Dept. of Industrial and Manufacturing EngineeringPeripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying blood to the lower extremities, which cause a progressive accumulation of ischemic injury. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, quality of life and walking parameters. Standard revascularization surgical procedures restore blood flow in the main arteries via bypass surgical grafting. However, nutrient transport and oxygen transfer take place at the level of the microvasculature and capillaries. Nevertheless, an assessment of the microvascular circulation is lacking. Multi-physics simulation software was used to model the phenomena to assess the effectiveness of the standard lower limb revascularization treatment in PAD patients who may have microvascular dysfunction. It was observed that there was 71.73 % decrease in the oxygen transferred to the surrounding tissues when there was blockage at the microvascular level. This model identifies the need to measure the microvascular circulation in the compromised limbs of PAD patients to optimize diagnosis and treatment strategies that reflect the underlying pathophysiology. Also the study suggests for early detection of PAD through screening methods. Current screening methods require trained personnel, special equipment and less accurate. In this study, we present a new sophisticated smart skin technology that could be used as a point-of-care continuous monitoring system for PAD screening. The smart skin biosensor was attached to a human arm phantom to detect blood blow changes. As a result the biosensor was able to detect blood flow in arm phantom and was also be able to record pulse volume changes in the blood flow. The result was then validated using ultrasound technique and found that the biosensor had 94% accuracy with the ultrasound measure
Assessment of arterial function recovery after surgical revascularization in PAD patients with micro-vascular insufficiency using computational model analysis
No full textPresented to the 11th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Heskett Center, Wichita State University, April 24, 2015.Research completed at Department of Industrial and Manufacturing Engineering, College of Engineering & Department of Biomedical Engineering, College of EngineeringPeripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries
supplying blood to the lower extremities, which cause a progressive accumulation of ischemic
injury. Despite revascularization treatment intervention some PAD patients require follow up
secondary treatment due to a continued decline in limb function, quality of life and walking
parameters. Standard revascularization surgical procedures restore blood flow in the main
arteries via bypass surgical grafting. Nutrient transport and oxygen transfer take place at the level
of the microvasculature and capillaries. However, an assessment of the microvascular circulation
is lacking. Microvascular dysfunction, a 'no flow' phenomena that may occur at the level of
microvasculature, may impair tissue oxygenation as well as nutrient transport and may therefore
be a contributor to the continued decline in limb function and walking parameters. Microvascular
dysfunction may be one of the dominating factors to be studied to understand the failure of the
arterial function recovery. Multi-physics simulation software was used to model the phenomena
to assess the effectiveness of the standard lower limb revascularization treatment in PAD patients
who may have microvascular dysfunction. Typical invasive revascularization surgery using
artificial bypass grafts to restore blood flow may fail to be effective if the PAD patient has
microvascular dysfunction. This model identifies the need to measure the microvascular
circulation in the compromised limbs of PAD patients to optimize diagnosis and treatment
strategies that reflect the underlying pathophysiology.Graduate School, Academic Affairs, University Librarie
Fluid structure interaction (FSI) modeling of abdominal aortic aneurysm (AAA) growth rate
No full textPresented to the 11th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Heskett Center, Wichita State University, April 24, 2015.Research completed at Department of Industrial and Manufacturing Engineering, College of Engineering & Department of Biomedical Engineering, College of EngineeringAn abdominal aortic aneurysm (AAA) occurs when there is a bulge formed in the large blood
vessels that supply blood to the abdomen, pelvis, and legs. Abdominal aortic aneurysms pose a
serious risk of rupture and can be life-threatening. Diagnosis of a life-threatening AAA is based
on measuring the diameter of the enlarged aorta. The diseased aortic wall is characterized by an
intraluminal thrombus (ILT), which is deposition of fatty acids, leads to narrowed aorta blood
vessel, and creates high pressure in the aneurysm sac. The objective of this study was to model
the growth of the aneurysm, by combining medical imaging and computational fluid dynamics
(CFD) in a time dependent study to determine wall stress, deformation, and fluid flow dynamics
over a certain period of time. This model may aid in clinical decision making to determine the
optimum time for surgical intervention by providing patient specific aneurysm growth-rate data
to avoid potential premature aneurysm rupture. A CT scan from an AAA patient was
reconstructed into a 3D CAD file, exported into multi-physics simulation software and simulated
as a fluid structure interaction model. Hypertensive blood-flow was simulated in the aorta wall,
modeled with degradation of aorta wall material properties over time using the Holzapfel Ogden
strain energy equation. The deformation in the wall over time was plotted using the time
dependent study to predict the growth for the enlarged diameter. The results indicate that vortex
formation, in the aneurysm sac, creates circulation zones and promotes fatty acids deposition on
the aorta wall for ILT formation. Combining the results of wall deformation along with wall
stress and blood velocity with respect to time, the model was able to estimate the growth of the
AAA and predict a time to rupture.Graduate School, Academic Affairs, University Librarie
Contribution of tin in electrochemical properties of zinc antimonate nanostructures: An electrode material for supercapacitors
No full textConcept of collective Nernstian-Capacitive mechanism in graphene nanosheets for electrochemical energy storage
No full textAlteration of proteins and pigments influence the function of photosystem I under iron deficiency from Chlamydomonas reinhardtii.
No full textBACKGROUND: Iron is an essential micronutrient for all organisms because it is a component of enzyme cofactors that catalyze redox reactions in fundamental metabolic processes. Even though iron is abundant on earth, it is often present in the insoluble ferric [Fe (III)] state, leaving many surface environments Fe-limited. The haploid green alga Chlamydomonas reinhardtii is used as a model organism for studying eukaryotic photosynthesis. This study explores structural and functional changes in PSI-LHCI supercomplexes under Fe deficiency as the eukaryotic photosynthetic apparatus adapts to Fe deficiency. RESULTS: 77K emission spectra and sucrose density gradient data show that PSI and LHCI subunits are affected under iron deficiency conditions. The visible circular dichroism (CD) spectra associated with strongly-coupled chlorophyll dimers increases in intensity. The change in CD signals of pigments originates from the modification of interactions between pigment molecules. Evidence from sucrose gradients and non-denaturing (green) gels indicates that PSI-LHCI levels were reduced after cells were grown for 72 h in Fe-deficient medium. Ultrafast fluorescence spectroscopy suggests that red-shifted pigments in the PSI-LHCI antenna were lost during Fe stress. Further, denaturing gel electrophoresis and immunoblot analysis reveals that levels of the PSI subunits PsaC and PsaD decreased, while PsaE was completely absent after Fe stress. The light harvesting complexes were also susceptible to iron deficiency, with Lhca1 and Lhca9 showing the most dramatic decreases. These changes in the number and composition of PSI-LHCI supercomplexes may be caused by reactive oxygen species, which increase under Fe deficiency conditions. CONCLUSIONS: Fe deficiency induces rapid reduction of the levels of photosynthetic pigments due to a decrease in chlorophyll synthesis. Chlorophyll is important not only as a light-harvesting pigment, but also has a structural role, particularly in the pigment-rich LHCI subunits. The reduced level of chlorophyll molecules inhibits the formation of large PSI-LHCI supercomplexes, further decreasing the photosynthetic efficiency
Fabrication of bismuth ferrite based hybrid nanostructures: Insight into a catalytic and sensing properties for the detection of biomolecules
No full textSunlight driven photocatalytic water splitting using nanostructured bismuth tungstate (Bi2WO6)
No full textSports Archetypes in The Novel Black Brother, Black Brother
No full textThis article analyzes the use of sports archetypes in Jewell Parker Rhodes\u27 novel "Black Brother, Black Brother." It explores how the author incorporates established tropes from sports fiction, such as the underdog storyline, training sequences, mentorship, and pivotal game moments, to elevate the narrative beyond a typical coming-of-age tale. The analysis focuses on how these archetypes are applied to the protagonist Donte Ellison\u27s journey in fencing, which becomes a vehicle for his personal development and exploration of identity. The document examines specific archetypes including the underdog, the mentor/coach, the training montage, the washed-up veteran, the loyal sidekick, the ultimate challenge, team spirit, and personal transformation through sports participation. It concludes that Rhodes skillfully intertwines these familiar tropes to create a powerful exploration of self-discovery, perseverance, and empowerment that resonates universally
In vitro studies of graphene oxide reinforced hydroxyapatite nanobiocomposite on human erythrocytes
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