12,920 research outputs found
SYNTHETIC CANNABINOIDS AND THE SEROTONIN SYNDROME: AN UNFORESEEN ASSOCIATION
No full textSYNTHETIC CANNABINOIDS AND THE SEROTONIN SYNDROME: AN UNFORESEEN ASSOCIATION Duccio Papanti 1, Laura Orsolini 2, Tommaso Bonavigo 1, Federico Sandri 1, Elisabetta Pascolo-Fabrici 1, Fabrizio Schifano 3 1 University of Trieste, Italia 2 University of Marche, Italia 3 University of Hertfordshire, UK Educational Objectives: Use of synthetic cannabinoids (SCs) has been increasingly associated with severe adverse effects, including deaths. SC intoxication is very different to cannabis one and shows common features with the serotonin syndrome. Purpose Synthetic cannabinoid compounds belong to a new psychoactive class of substances misused as an alternative to marijuana (MJ). These compounds have been developed for research purposes and have never been tested in clinical human studies. Currently, SCs can be easily bought on a global level, both online and in local stores. We aimed here at identifying SC pharmacodynamics, effects/symptoms of intoxication and neurobehavioral sequaelae in humans, with a focus on findings compatible/common to the serotonin syndrome. Methods: A search was carried out on PubMed/Medline for the terms “synthetic cannabimimetics”, “synthetic cannabinoids”, “synthetic cannabis” in order to identify effects/symptoms of intoxication, neurobehavioral sequaelae related to SC intake in humans. Results: SC compounds are structurally dissimilar and incorporate indole mojeties, not present in MJ. SC are full agonists on cannabinoid receptors (CB-rs) while cannabis main psychoactive, tetrahydrocannabinol (THC), exerts partial agonism on cannabinoid receptors. SCs visual hallucinations are described as fractals/trails/flashes of colour/geometric patterns [1]. Signs of intoxication are elevated heart rate; hallucinations; mydriasis; agitation; vomiting; and seizures; these signs are common in the serotonin syndrome. Indole is structurally similar to serotonin (5-HT), has activity on 5-HT receptors and is typically identified within indoleamine hallucinogens such as DMT. While 5-HT2A receptors are the primary site of action for DMT (typically producing visual geometric hallucinations in the users), the agonism of 5-HT2A receptors contributes substantially to the development of the serotonin syndrome. Conclusions: Beside the well-known cannabimimetic properties, SC drugs could have additive hallucinogenic effects due to the indole mojeties incorporated in their structures. SCs intake/intoxication can produce acute signs/symptoms/clinical findings belonging to the serotonin syndrome. Literature Reference [1] Spaderna, M., Addy, P.H., D’Souza, D.C., 2013. Spicing thin
Role of the extracellular matrix protein SPARC in human melanoma tumor progression
No full textFil: Alvarez, Mariano Javier. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Aportes de los espacios públicos en la construcción de la legibilidad urbana y la identidad orientados a las políticas públicas en el desarrollo local en ciudades medianas y pequeñas. Casos de estudio: Villa María, Bell Ville, Villa Nueva, Mendiolaza, Brinkmann, Canals, Noetinger y Embajador Martini
No full textFil: Yánez, Javier. Universidad Nacional Villa María; Argentina.Fil: Alvarez, Marcelo. Universidad Nacional Villa María; Argentina.Fil: Moya, Adriana, . Universidad Nacional de Villa María; Argentina.Fil: Sánchez, Mónica, . Universidad Nacional de Villa María; Argentina
Institutional Memories, Collection donated by Dr. Javier Peña (Part 1 of 3)
No full textPhotographic selection of institutional reports by Dr. Javier Peña, contains images of laboratory activities and training courses in El Batan and Ciudad Obregón, Mexico from 1974 to 1986.Color PhotographRoberto Javier Peña BautistaAlfonso Arnoldo Amaya CelisGuillermo Lopez De La TorreMartha Ibañez RemoladoLiliana TrocheJoaquin Arias LopezSalvador TruebaArmando MontañoJesus Rodriguez LunaMartin RodriguezElena MolfeseTsehay BekeleJessica Valdez EspejelFainesi BwakayaElsa Espinosa LopezByrd C. CurtisLeticia GonzalesHomer HepworthArthur R. KlattAlvaro CocaH. Jesse DubinZhou XidanChen WeiweiLin XiaomaniEfren Del ToroLeticia DiazAbdul Mujeeb KaziFausto Cervantes LopezJuan BalderasHector GonzalesOrlando GarridoCarmen R. HuarcayaJorge Zarco HernandezEliana Maria GuarientiCarlos VegaGilberto HernandezAlicia JimenezMaria Brigida Scholz dos SantosClaudio R. Cafati KomiatzkiSergio VegaMartha Patricia PeñaJuan Bautista Alvarez CabelloAna Laura SeguezzoDaniel VazquezAllan LiavogaArturo FuentesRaul Ruiz Esparz
Estudio de las transformaciones urbano-territoriales del conglomerado Villa María-Villa Nueva en sus áreas centrales y pericentrales
No full textFil: Yánez, Javier. Universidad Nacional de Villa María; Argentina.Fil: Alvarez, Marcelo. Universidad Nacional de Villa María; Argentina.Fil: Moya, Adriana, . Universidad Nacional de Villa María; Argentina.Fil: Sánchez, Mónica Elisa. Universidad Nacional de Villa María; Argentina
Reflexiones sobre los impactos socio-espaciales de los procesos de transformación urbana en las áreas central, pericentral y periférica del conglomerado Villa María-Villa Nueva
No full textFil: Sánchez, Mónica, . Universidad Nacional de Villa María; Argentina.Fil: Moya, Adriana, . Universidad Nacional de Villa María; Argentina.Fil: Yánez, Javier. Universidad Nacional de Villa María; Argentina.Fil: Alvarez, Marcelo. Universidad Nacional de Villa María; Argentina
Aplicación de técnicas de vídeo para la determinación de la batimetría
No full textTrabajo final presentado por Javier Alvarez van Strahlen para obtenrer el grado por la Universitat Politècnica de Catalunya (UPC), realizado bajo la dirección del Dr. Gonzalo Simarro del Institut de Ciències del Mar (ICM-CSIC
An Introduction to the Life and Work of Javier Alvarez
No full textThis thesis aims to become the first scholarly research document devoted to the life and work of Mexican postmodern composer Javier Alvarez. It contains the most detailed and up-to-date account of the composer’s biography and compositional style, along with a brief analysis of Metal of Hearts (Metal de corazones) one of his most recent works. The information presented is based on hundreds of primary source documents, an interview with the composer conducted over the course of three days, and academic sources only available in Spanish.Music, Moores School o
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