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    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    New concepts in feedback regulation of glucose metabolism

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    Evaluation of the effects feedback strength.

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    <p>Forward and backward dose response curves for varying feedback strengths, α = 1 (blue), α = 2 (red), and α = 5 (yellow). Different markers correspond to the forward and backward dose response. At high feedback strengths, the response is irreversible. At low feedback strengths, the active state can reverted be back to the inactive state. Again, values are calculated at t = 50 minutes.</p

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Diagrams of the simplified signaling networks used in the computer simulations.

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    <p>a.) An overall scheme for the signaling model to be simulated. Parallel pathways, whose activation occurs at different time scales, converge to produce cytokine. b–d.) Reaction schemes for each model, b.) linear c.) cooperative and d.) feedback induced models for persistent activity cFOS.</p

    Comparison of the distributions of active IEGs and Cytokine production for different models.

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    <p>a–d, results from feedback model. e,f, results from a linear model. Probability distributions are computed at three time points, t = 30 minutes (after first round of stimulation) red , t = 50 minutes (after first period of interrupted signaling) green , and t = 80 minutes (after the completion of the second round of signaling) blue. IEG products (a,b,e) and Cytokine production (c,d,f) are considered. In the presence of a feedback loop, two separate cases (strong (a,c) and weak (b,d) signal strength are analyzed.</p
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