104 research outputs found

    sj-docx-1-pam-10.1177_27536386231175520 - Supplemental material for Lessons from the first two years of a new out-of-hospital airway registry in New South Wales

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    Supplemental material, sj-docx-1-pam-10.1177_27536386231175520 for Lessons from the first two years of a new out-of-hospital airway registry in New South Wales by Martin Nichols, Pieter Francsois Fouche, Thomas McPherson, Tom Evens and Jason Bendall in Paramedicine</p

    A leaf from the Bendall "Vamsavali"

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    The language of the manuscript in question is difficult. One part is written in Sanskrit and the other part in old Newari. Bendall borrowed the manuscript and it was taken to London for research, resulting in the article: 'The History of Nepal and Surrounding Kingdoms'. The author challenges some of the interpretations of the manuscript and looks to correct a few mistakes in the book that was subsequently published using the original interprepation

    Teleost and elasmobranch eye lenses as a target for life-history stable isotope analyses

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    Incrementally grown, metabolically inert tissues such as fish otoliths provide biochemical records that can used to infer behavior and physiology throughout the lifetime of the individual. Organic tissues are particularly useful as the stable isotope composition of the organic component can provide information about diet, trophic level and location. Unfortunately, inert, incrementally grown organic tissues are relatively uncommon. The vertebrate eye lens, however, is formed via sequential deposition of protein-filled fiber cells, which are subsequently metabolically inert. Lenses therefore have the potential to serve as biochemical data recorders capturing life-long variations in dietary and spatial ecology. Here we review the state of knowledge regarding the structure and formation of fish eye lenses in the context of using lens tissue for retrospective isotopic analysis. We discuss the relationship between eye lens diameter and body size, describe the successful recovery of expected isotopic gradients throughout ontogeny and between species, and quantify the isotopic offset between lens protein and white muscle tissue. We show that fish eye lens protein is an attractive host for recovery of stable isotope life histories, particularly for juvenile life stages, and especially in elasmobranchs lacking otoliths, but interpretation of lens-based records is complicated by species-specific uncertainties associated with lens growth rates

    Does The Use Of Simulation Enhance The Development Of Registered Physiotherapist’s Respiratory ‘On-Call’ Skills – A Literature Review

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    Background and aim: On-call respiratory physiotherapy is utilized when an acutely unwell patient could deteriorate without immediate assessment and treatment overnight. Education related to this topic varies greatly and is often of poor quality. Simulation-based education (SBE) has been increasingly used within other areas of healthcare yet, Gough et al. [1] completed a study in 2013, which found only 39% of acute trusts used simulation for respiratory on-call training. Aim: To determine from existing research, whether SBE can enhance the development of registered physiotherapists respiratory ‘on-call’ skills in order to impact future practice. Methods: A qualitative literature review was completed as part of a PgCert in Health Simulation at Coventry University, in March 2023. Ethical approval was gained from Coventry University (P149952). Studies included were found by searching AMED, CINAHL Embase and Medline databases. Figure 1-A20 presents the PRISMA flow diagram [2]. Final reports included were critically analysed using the Critical Appraisal Skills Programme framework [3] and data extracted and formatted into a table. General themes were identified using an inductive approach. Results: Eleven papers were selected to be reviewed after the removal of duplicates, screening and the exclusion criteria were applied. The main themes identified were the use of high-fidelity simulation, the measure of confidence and/or competence, and findings of positive implications for practice. SBE is widely used for other healthcare professions with positive outcomes; however, its use within respiratory physiotherapy is limited. Most studies chose to measure self-reported levels of competence and confidence, which is an example of Kirkpatrick level-one evaluation. These measures have only casual links to transfer of knowledge and behaviour change, which are key requirements when applying training to clinical settings. Interestingly, the review also demonstrates favourable use of high-fidelity manikins within this population. Although this was not discussed by the researchers, this may be a barrier for further implementation due to cost and technical knowledge required to use the equipment. Conclusion: The use of SBE has been beneficial in other healthcare professions and similar positives were found for its use with respiratory physiotherapists. However, much of the research is of low quality, and further research is required to review other confounding factors that may influence the outcomes and longitudinal staff behaviour. Ethics statement: Authors confirm that all relevant ethical standards for research conduct and dissemination have been met. The submitting author confirms that relevant ethical approval was granted, if applicable

    Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression

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    Abstract not availableCraig T. Wallington-Beddoe, Jason A. Powell, Daochen Tong, Stuart M. Pitson, Kenneth F. Bradstock and Linda J. Bendal

    The Coinage of Constantine XI

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    Summary. — In the light of a hoard of 158 silver Palaeologan coins, from John V (1354- 1391) to 1453, the author discusses the complete coinage of the last Byzantine emperor, Constantine XI (1448-1453). The existence of this coinage was known from literary sources but the first coin did not appear on the market until 1974. This hoard adds five half-sta vrata to the two previously known and reveals 35 stavrata and 50 1/8 stavrata which were previously unpublished. A die study indicates a considerably larger issue than is apparent from the present rarity of the coins which can be explained by the sudden end to their circulation.Bendall Simon. The Coinage of Constantine XI. In: Revue numismatique, 6e série - Tome 33, année 1991 pp. 134-142

    Prehospital non-invasive ventilation for acute cardiogenic pulmonary oedema : an evidence-based review

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    Background: Non-invasive ventilation (NIV) is increasingly being implemented by many ambulance jurisdictions as a standard of care in the out-of-hospital management of acute cardiogenic pulmonary oedema (ACPO). This implementation appears to be based on the body of evidence from the emergency department (ED) setting, with the assumption that earlier administration by paramedics would give benefits with regard to inhospital mortality and the rate of endotracheal intubation beyond those seen when initiated in the ED. This paper sought to identify and review the current level of evidence supporting NIV in the prehospital setting. Methods: Electronic searches of Medline, EMBASE, CINAHL, Cochrane Database of Systematic Reviews and Cochrane Database of Controlled Trials were conducted and reference lists of relevant articles were hand searched. Results: The search identified 12 primary studies documenting the use of NIV, either continuous positive airway pressure or bi-level non-invasive ventilation, for ACPO in the out-of-hospital setting. Only three studies were randomised controlled trials, with none addressing inhospital mortality as a primary outcome measure. The majority of articles were non-comparative descriptive studies. Conclusion: Early prehospital NIV appears to be a safe and feasible therapy that results in faster improvement in physiological status and may decrease the need for intubation when compared with delayed administration in the ED. There is weak evidence that is may decrease mortality. The cost versus benefit equation of system-wide prehospital implementation of NIV is unclear and, based on the current evidence, should be considered with caution

    The Influence of Paramedic and Patient Gender on the Administration of Analgesics in the Out-of-Hospital Setting

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    Objective. To determine whether analgesic administration in the out-of-hospital setting is influenced by the gender of the patient or the gender of the paramedic. Methods. This retrospective cohort study of patient care records included adult patients (age > 15 years) with moderate to severe pain (verbal numerical rating score 4–10) treated by paramedics between January 1, 2008 and December 31, 2009. Data extracted included patient pain severity score, analgesia provided by paramedics, and gender of the treating paramedic. Data was analyzed by descriptive statistics, χ2 test, and logistic regression. The primary outcome measures were the effect of patient and paramedic gender on analgesic administration. Results. The study population comprised 42,051 patients, median age of 57 years (38–75); 50.4% were female and 51% were administered an analgesic agent. For the outcome of receiving any analgesia, neither patient gender nor paramedic gender was predictive (p = NS). In a multivariate model for the outcome of receiving any analgesia, patient gender, paramedic gender, and the interaction between patient and paramedic gender were all nonsignificant (p = NS). For the outcome of receiving opioid analgesia (i.e., morphine or fentanyl), male patients were at greater odds of receiving an opioid (OR 1.52, 95% CI 1.29–1.79, p less than 0.0001). Paramedic gender was not predictive of whether an opioid was given (p = NS). Conclusions. The gender of the paramedic did not appear to influence the odds of analgesic administration. Female patients were less likely to receive opioids. Paramedic gender does not explain this finding
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