63 research outputs found
Radmilo Pekić: Florentines in the Balkans 1300-1600, Faculty of philosophy, Kosovska Mitrovica, 2012
No full textIn the monograph The Florentines in the Balkans 1300-1600, the main topic is Florence’s trade in the Balkans, in the period from the fourteenth to the seventeenth century. This historical period is the subject of the author's scientific research. The fact is that neither in Serbian nor in European historiography, with the exception of a few fragmentary works, there is no comprehensive survey to date of the Florentines’ role in the Balkans. Writing the book, the author was faced with extensive and varied problems. To make his monograph more accessible and more acceptable to the readers, he divided the text in five main chapters (Review of the history of Florence and its pollitical ties with the Balkan countries (pp. 14-38), Florence’s trade in the Balkans 1300-1600 (p. 39-156), Forms and organization of Florentine business in the Balkans 1300-1600 (p.157-311), Prominent Florentines in the Balkans 1300-1600 (pp. 312-374), The Private Life of Florentines (pp. 375-452)), not including ancillary and methodologically planned topics, and within them a greater or lesser number of headings. The author covered all the segments of the temporal and spatial scope of the research. This monograph contains pedagogical criteria in addition to his basic content. The handling of facts and conclusions reflects the professional, scientific and narrative high level of the author. He shows a subtle sense for identifying and defining problems, he logically and gradually develops the topics, he is consequential in his conclusions and his arguments. This monograph by Radmilo Pekić is written meticulously and the author is critically aware of the methodology of scientific research. His work is based on some authentic and original material, not disclosed until now. That’s why it is, indeed, an important scientific work and a valuable contribution to the understanding of political, economic and cultural history of Florentines in this important and strategic sensitive area
SAFE EXTUBATION AND REINTUBATION IN OPERATORY ROOM AND ICU PATIENTS
No full textEach intubation should result in an extubation at end of procedure, and each extubation, theoretically, could represent a potential reintubation due
to extubation manoeuvre failure. There are many and different reasons for extubation to fail, starting from mechanical iatrogenic lesions due to difficult intubation up to patient’s inhability to sustain spontaneous breathing and unassisted ventilation, going through extubation associated respiratory and cardiovascular complications, local mechanic or
inflammatory factors, surgical techniques and accidental events. Recent literature has clearly shown that if critical events associated with difficult intubation have lower
incidence thanks to guidelines diffusion and implementation, extubation related accidents did not change incidence and consequences in last couple of decades. This observation has led to developement of dedicated extubation guidelines and to attention from Scientific Community to promote culture of safety and anticipation, with predicted difficult extubation concept and protected extubation strategies, by using pharmacological and technical approach. Aim of this paper is to review data for extubation related accidents, to provide overview with existing guidelines and description of approaches to predict difficult extubation, techniques to provide best extubation
strategies including pharmacologic, non pharmacologic and instrumental techniques
ON LINGUISTIC INTERPRETATION OF SLOBODAN NOVAK'S NOVEL PRISTAJANJE
No full textOsnovna svrha rada je dati uvid u mogućnosti stilističke interpretacije književnoga teksta vodeći se isključivo načelima lingvističke stilistike. Prozni predložak uzet u analizu je roman Pristajanje Slobodana Novaka. Na odabranome proznom predlošku, koji se odlikuje višeslojnošću, aluzivnošću i stilskom dotjeranošću, u radu se izdvajaju i interpreteiraju stilogeni jezični elemenati korišteni radi postizanja ironičnog učinka. Pored toga, rad utvrđuje postojanje specifičnih elemenata stilematike autorova književnog izričaja te ih postavlja u kontekst s odabranim jezičnim elementima u romanu Pristajanje. Lingvostilistička interpretacija u radu usredotočena je na leksičku i na sintaktičku razinu jezika jer se smatra da se specifičnosti autorova stila najizrazitije zamjećuju upravo na tim razinama.The main aim of this paper is to provide an insight into the possibilities of stylistic interpretation of a literary text by using only the principles of linguistic stylistics. The prosaic sample taken into consideration in this paper is Slobodan Novak's novel Pristajanje. This novel is characterized by complexity, allusiveness and stylistic refinement, so in this paper the author selects and interprets stylistic linguistic elements used for achieving ironic effects. Additionally, the paper determines the existence of specific elements of the author's literary expression and puts them in context with selected linguistic elements in the novel. Linguistic and stylistic interpretation is focused on lexical and syntactic level of the language, because it is considered that the author's specific style is the most commonly noticed on those levels
The inhabitants of Gacko at work in Dubrovnik (XIV-XV century)
No full textThe process of emigration from the area of Hum and Trebinje area to medieval Dubrovnik as a phenomenon existed for centuries. The causes for this were differents in different periods, and it's already well documented. However, from this broad process, this paper is limited to the population of Gacko only, which emigrated during the XIV and XV century in Dubrovnik to find a job and to learn a skill of a craft. On the basis of published and unpublished sources from Dubrovnik, the author establishes the conditions under which the medieval population from Gacko served and learned crafts in Dubrovnik
Implications of anesthetic techniques on patients' recovery in laparoscopic cholecystectomy
No full textBackground/Aim. Different techniques of general anesthesia are used for laparoscopic cholecystectomy (LC). The aim of the study was to establish the best anesthetic technique for achieving better results during awakening affecting not only patient's recovery, but activities of anesthesiological team, as well. Methods. The study was conducted as a prospective comparative clinical trial. The patients (n=90) were classified according to the applied anesthetic technique into two groups: Volatile Induction and Maintenance Anesthesia (VIMA) with sevofluran and Target Controlled Infusion (TCI). The results relating to parameters of recovery after anesthesia and surgery were compared between these two groups. The following parameters were analyzed: demographic patients' characteristics, duration of anesthesia, the times to eye opening, to respond to a command, to extubation, and to orientation, from the last anesthetic dose receiving until post anesthesia discharge (PAD), frequency of postoperative nausea, vomiting and agitation (PONVA). Results. In the examined groups there were no statistically significant differences in the duration of anesthesia (68.29 ? 6.47 vs 66.29 ? 11.97 min, p = 0.327). The time to eye opening was significantly shorter in the group VIMA compared to the group TCI (4.49 ? 1.20 vs 7.42 ? 1.25 min, p = 0.000), as well as the time to respond to a command (5.93 ? 1.12 vs 8.47 ? 1.08 min, p = 0.000). The patients anesthetized with VIMA technique were statistically significantly extubated earlier (6.84 ? 1.19 vs 9.69 ? 1.31 min, p = 0.000). Considering orientation time, there was also statistically significant difference between the two groups (7.51 ? 0.97 vs 11.60 ? 1.75 min, p = 0.000). There was no statistically significant difference in PAD time duration (19.42 ? 5.99 vs 20.80 ? 1.59 min, p = 0.142). There were no statistically significant differences in PONVA events between the examined groups. Conclusion. This study showed that VIMA technique with sevofluran in LC provides faster and more qualitative recovery of patients. Thus this technique should be applied in everyday anesthesiological procedures in LC, as well as in other minimally invasive videoendoscopic surgical procedures.</jats:p
Sepseast and covid-19: Time to make a difference
No full textSepsEast is an enthusiastic intensivists group initiative launched in 2012, with the aim to facilitate clinical and research activities in the region. Through its actions and with the motto « Together we win, divided we are slow! » several joint research projects in the fields of perioperative medicine, fluid therapy, cardiovascular monitoring and support have been conducted. In the light of the COVID-19 pandemic, the SepsEast community is aware of its mission and is ready to take the challenge. This is mirrored by several educational, clinical and research activities including the development of a COVID-19 Registry; and an observational clinical study on cytokine adsorption in COVID-19 patients. The current pandemic should be our lesson on how to manage the global threat of infectious disease and to develop strategies for effective diagnostic and therapeutic procedures. Hopefully, the SepsEast community will contribute to these developments and scientific advances in general
Caffeic acid phenethyl ester attenuates changes in pancreatic tissue damage biomarkers induced by cisplatin
No full textApplication of cisplatin (CP) for the treatment of different cancers is known to cause pancreatitis, through an increase in reactive oxygen species (ROS) production, and promotion of inflammation. Caffeic acid phenethyl ester (CAPE), the main activity carrier of propolis extracts, was previously found to possess numerous beneficial properties. This study aims to determine for the first time the potential of CAPE in preventing CP-induced pancreatic tissue damage by studying the changes occurring on both biochemical and microscopic levels. The levels of serum α-amylase and a panel of pancreatic tissue biomarkers related to tissue injury (reduced glutathione, xanthine oxidase, malondialdehyde, protein carbonylated concentration) and inflammation (myeloperoxidase, nitric oxide and TNF-α) would be studied in male Wistar rats treated with either CP alone or with CP and CAPE. Additionally, microscopic analysis of pancreatic tissue would be conducted as well. Application of CAPE together with CP, statistically significantly prevented the disturbance in all here-studied pancreatic tissue damage and inflammation-related biomarkers. The changes in pancreas biochemical status was followed by the morphological disturbance. The results of the present study suggest that CAPE could act as a protective agent in pancreatic damage that arises after CP application.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
The Perioperative Pain Management Bundle is Feasible
No full textOBJECTIVES
The quality of postoperative pain management is often poor. A 'bundle', a small set of evidence-based interventions, is associated with improved outcomes in different settings. We assessed whether staff caring for surgical patients could implement a 'Perioperative Pain Management Bundle' and whether this would be associated with improved multi-dimensional pain-related Patient-Reported-Outcomes (PROs).
METHODS
PAIN OUT, a perioperative pain registry, offers tools for auditing pain-related PROs and obtaining information about perioperative pain management during the first 24 hours after surgery. Staff from 10 hospitals in Serbia used this methodology to collect data at baseline. They then implemented the 'perioperative pain management bundle' into the clinical routine and collected another round of data. The bundle consists of four treatment elements: (1) a full daily dose of 1-2 non-opioid analgesics (e.g. paracetamol, NSAIDs); (2) at least one type of local/regional anesthesia; (3) pain assessment by staff; (4) offering patients information about pain management. The primary endpoint was a multi-dimensional pain composite score (PCS), evaluating pain intensity, interference and side-effects: It was compared between patients who received the full bundlevs.not.
RESULTS
Implementation of the complete bundle was associated with a significant reduction in the PCS (P<0.001, small-medium effect size [ES]). When each treatment element was evaluated independently, non-opioid analgesics were associated with a higher PCS (i.e. poorer outcome; negligible ES); the other elements were associated with a lower PCS (all negligible-small ES). Individual PROs were consistently better in patients receiving the full bundle compared to 0-3 elements. The PCS was not associated with surgical discipline.
DISCUSSION
We report findings from using a bundle approach for perioperative pain management in patients undergoing mixed surgical procedures. Future work will seek strategies to improve the effect.
TRIAL REGISTRATION
ClinicalTrials.gov identified NCT02083835
Treating patients across European Union borders
No full textBACKGROUND In light of the coronavirus disease-2019 (COVID-19) pandemic, how resources are managed and the critically ill are allocated must be reviewed. Although ethical recommendations have been published, strategies for dealing with overcapacity of critical care resources have so far not been addressed. OBJECTIVES Assess expert opinion for allocation preferences regarding the growing imbalance between supply and demand for medical resources. DESIGN A 10-item questionnaire was developed and sent to the most prominent members of the European Society of Anaesthesiology and Intensive Care (ESAIC). SETTING Survey via a web-based platform. PATIENTS Respondents were members of the National Anaesthesiologists Societies Committee and Council Members of the ESAIC; 74 of 80 (92.5%), responded to the survey. MEASUREMENTS AND MAIN RESULTS Responses were analysed thematically. The majority of respondents (83.8%), indicated that resources for COVID-19 were available at the time of the survey. Of the representatives of the ESAIC governing bodies, 58.9% favoured an allocation of excess critical care capacity: 69% wished to make them available to supraregional patients, whereas 30.9% preferred to keep the resources available for the local population. Regarding the type of distribution of resources, 35.3% preferred to make critical care available, 32.4% favoured the allocation of medical equipment and 32.4% wished to support both options. The majority (59.5%) supported the implementation of a central European institution to manage such resource allocation. CONCLUSION Experts in critical care support the allocation of resources from centres with overcapacity. The results indicate the need for centrally administered allocation mechanisms that are not based on ethically disputable triage systems. It seems, therefore, that there is wide acceptance and solidarity among the European anaesthesiological community that local medical and human pressure should be relieved during a pandemic by implementing national and international re-allocation strategies among healthcare providers and healthcare systems
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