1,721,661 research outputs found
An Hsp90 physical interactome
Get PDFSubmission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo termsThe student, Janhavi Kolhe, accepted the attached license on 2022-11-28 at 09:41.The student, Janhavi Kolhe, submitted this Dissertation for approval on 2022-11-28 at 09:44.This Dissertation was approved for publication on 2022-11-29 at 10:39.DSpace SAF Submission Ingestion Package generated from Vireo submission #18643 on 2023-04-12 at 07:34:02Hsp90 is a critical eukaryotic molecular chaperone, ubiquitously expressed in all organisms. It is a highly abundant protein (~2% of a cell’s protein mass) and is involved in numerous processes including protein trafficking, chromatin remodeling, and signal transduction. To govern a broad variety of biological pathways Hsp90 exploits two different modes of interactions with clients and/or co-chaperones - a stable association such as when maintaining a metastable client in a soluble state and a transient binding such as when driving the dynamics of proteins working in transcription, chromatin remodeling, or DNA repair. Despite the numerous and extensive studies on Hsp90, the complete clientele of Hsp90 is unknown. Likely, the transient interactions between Hsp90 and many of its clients make their identification through traditional techniques difficult. To gain a better understanding of the factors interacting with Hsp90, I exploited the non-natural amino acid p-Benzoyl-L-Phenylalanine (Bpa) to generate an in vivo kinetic trap to capture Hsp90 interactions. In conjunction with mass spectrometry, I have identified 1114 physical interactors of Hsp90. Nearly half of the hits were novel for Hsp90-association and included pathways such as translation initiation and genome organization. My studies provide mechanistic insights into Hsp90 as a molecular chaperone as well as its functional role in different cellular processes
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Culture and age influences upon gambling and problem gambling
Get PDFAbstract not availableMythily Subramaniam, Edimansyah Abdin, Shazana Shahwan, Janhavi Ajit Vaingankar, Louisa Picco, Colette Joy Browning, Shane Andrew Thomas, Siow Ann Chon
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
