258 research outputs found
Die "puls" – Experimentalarchäologische Untersuchungen zu einer antiken römischen Getreidebreizubereitung
No full textStudies by the author in experimental archaeology have been dealing with the (re-)production of the ancient Roman meal “puls” since 2012. This porridge puls was mainly prepared with wheat and other grains and it can be considered as the ancient Roman “national dish” par excellence, according to literary evidence. Concerning the recipes, puls is mentioned by the author Cato and especially by a recipe collection attributed to the legendary gourmet and gourmand Apicius. Additionally, puls is also proven by archaeological evidence. Due to the simple preparation, archaeological as well as historical sources, and ethnographic comparisons, it can be assumed that puls was a very common meal in both the civil and military sectors. The experimental archaeological investigations deal with the production process (both in laboratory and field tests), the physical properties of the porridge puls during the cooking process, and an analysis of the sensory characteristics
"PULS." - Ein Blog als Online-Magazin für Medizinstudierende der Goethe-Universität Frankfurt
No full textIm Herbst 2009 forderten Studierende im Rahmen landesweiter Proteste auch am Fachbereich Medizin/Zahnmedizin der Goethe-Universität Frankfurt mehr Transparenz und Kommunikation zu Angelegenheiten ihres Studiums. Einen innovativen Lösungsansatz, um diesen Forderungen nachzukommen, bietet eines der Web 2.0 Werkzeuge: ein auf einer Blog-Software basierendes Online-Magazin für Studierende und andere Mitglieder des Fachbereichs.
Das öffentlich zugängliche Online-Magazin "PULS." (https://newsmagazin.puls.med.uni-frankfurt.de/wp/) wird mit einer freien Blog-Software (wordpress Version 3.1.3.) realisiert und von einer Online-Redakteurin konzipiert und geschrieben. Die Beiträge entstehen nach eigenen Recherchen sowie aus Anregungen und Gesprächen mit verschiedenen Personengruppen des Fachbereichs. Die datenschutzkonforme Auswertung der Zugriffe erfolgt über eine open-source Webanalyse-Software (Piwik). Zusätzlich werden jährlich mit dem Online-Umfrage-Tool Survey Monkey die Nutzer anonym befragt.
"PULS." ist seit dem 14.02.2010 ununterbrochen online und hat seitdem 806 Beiträge (Stand: 27.11.2012) publiziert und wird von ca. 2400 Besuchern monatlich gelesen. Das Themenspektrum ist zentriert auf die Anliegen der Frankfurter Medizin- und Zahnmedizinstudierenden. Die enge Zusammenarbeit mit verschiedenen Gruppierungen des Fachbereichs – Dekanat, Studierende und Lehrende – garantiert darüber hinaus ein fachbereichs-relevantes Themenspektrum. Das Online-Magazin begleitet komplexe Projekte und Entscheidungen mit Hintergrundinformationen und kommuniziert sie verständlich. Eine jährliche Nutzer-Evaluierung zeigt eine wachsende Leserzahl und eine sehr hohe Zustimmung für das Online-Magazin, seine Inhalte und seinen Stil. Das Web 2.0-Medium "Blog" und seine web-typische Sprache entsprechen dem Medienverhalten der Zielgruppe, d.h. den Studierenden des Fachbereichs Medizin.
"PULS." hat sich als ein geeignetes und strategisches Instrument erwiesen, um größere Transparenz, mehr Kommunikation und letztendlich eine stärkere Identifikation der Studierenden mit ihrem Fachbereich voranzutreiben
Synchronisatie van het puls frekwentie modulaat
No full textEen puls frekwentie modulator (VCO) is een zeer eenvoudige AD-convertor. Synchronisatie van het puls frekwentie modulaat bezit overeenkomsten met het Sigma Delta Modulaat (ƩDM). In dit rapport wordt onderzocht; ① Beperkingen en toepasbaarheid van de ECL-VCO de F11C58. ② Kwantisatie ruis vermindering door interne klok verdubbeling. ③ Kwantisatie ruis compensatie van het gedemoduleerde synchrone frekwentie modulaat met het onderdoorlaat gefilterde synchrone frekwentie modulaat.Applied SciencesTransmissie van Informati
Enkele aspecten van een optisch transmissie systeem gebruik makende van puls plaats modulatie
No full textEen glasvezeltransmissie systeem wordt algemeen beschreven. Daarna wordt ingegaan op het ruis gedrag van de bipolaire en de fieldeffect transistor in optische ontvangschakelingen. Hierbij worden zowel tegengekoppelde als niet tegengekoppelde configuraties in beschouwing genomen. Vervolgens wordt een ontvangfilter achter de versterker opgenomen. De invloed van dit filter op de signaal ruis verhouding bij Puls Plaats Modulatie wordt onderzocht. De bedoeling is om een zo gunstig mogelijke signaal ruis verhouding te krijgen door het toepassen van een ontvangfilter. Voor het optimale filter bestaat echter geen exacte oplossing. In de literatuur worden dan ook slechts benaderingen aangegéven. Zo'n benadering die gebruik maakt van Gauss-pulsen en een Gauss ontvangfilter wordt beschreven -door Hullett en Muoi. Aan deze beschrijving wordt hier een uitbreiding gegeven door de intersymbool interferentie in rekening te brengen. Deze is een gevolg van d« pulsverbreding door het ontvangfilter. Vervolgens wordt via een daarvoor ontwikkeld computer programma de berekening mogelijk gemaakt voor willekeurige pulsvormen en ontvangfilter frequentie karakteristieken. Uit de berekeningen blijkt dat het ontvangfilter een zo lineair mogelijke fase frequentie karakteristiek moet hebben. Van de toegepaste pulsen, een Gaussvormige puls en een cosinus kwadraatvormige puls, blijkt de cosinus kwadraatvormige puls betere resultaten op te leveren. Door tijdgebrek konden niet voldoende metingen worden verricht om de theorie te toetsen.Applied SciencesTransmissie van Informati
PULS 90 - ein systemumfassender Ansatz zur Leistungssteigerung von Eisenbahnnetzen
No full textNeue Planungsmethoden und innovative Betriebsprozesse sind gefordert, um die Leistungsfähigkeit hochbelasteter Eisenbahnnetze zu steigern. SBB Infrastruktur startete dazu das Programm PULS 90 mit Unterstützung der ETH Zürich. Die Kernelemente dieses Programms werden nachfolgend vorgestell
PULS 90 - ein systemumfassender Ansatz zur Leistungssteigerung von Eisenbahnnetzen
No full textNeue Planungsmethoden und innovative Betriebsprozesse sind gefordert, um die Leistungsfähigkeit hochbelasteter Eisenbahnnetze zu steigern. SBB Infrastruktur startete dazu das Programm PULS 90 mit Unterstützung der ETH Zürich. Die Kernelemente dieses Programms werden nachfolgend vorgestell
Dissecting the cellular effects of antimicrobial agents: The spatio-temporal impact of peptidoglycan synthesis inhibiting antibiotics in <em>Staphylococcus aureus</em> and mechanism of action elucidation of epilancin A37
No full textThe increasing threat of antibiotic resistance requires innovation in antibiotic research and development. However, the knowledge of how antimicrobial agents kill bacteria is still limited, even for clinically relevant antibiotics. Bacterial cell wall biosynthesis is the target of many important antibiotics. Its spatiotemporal organization is closely coordinated with cell division. However, the roles of the cell wall biosynthesis machinery (CWBM) and peptidoglycan synthesis (PGS) within cell division are not fully understood. Even less is known about the impact of antibiotics on the coordination of these two essential processes.
In this work, the cellular effects of clinically used PGS-targeting antibiotics on Staphylococcus aureus were investigated to construct a model of how PGS inhibition impacts the spatio-temporal organization of the CWBM and cell division. Blocking the ultimate PGS substrate lipid II with the glycopeptide antibiotics vancomycin or telavancin caused a complete inhibition of septum constriction. The beta-lactam oxacillin stopped cell division by preventing recruitment of the major peptidoglycan synthase PBP2 to the septum. Accordingly, this work identifies cell division as a main cellular target of PGS-targeting antibiotics. It further provides evidence that PGS is the essential driving force of septum constriction throughout cell division of S. aureus and reveals PBP2 as being crucial for septum closure. Inhibition of PGS was found to ultimately cause total arrest of S. aureus cell division. This newly established framework was subsequently used to investigate the cellular effects of the PGS-inhibiting natural product moenomycin and the small synthetic molecule DCAP on the CWBM and cell division. Moenomycin was found to impair cell splitting independent from its PGS-inhibiting action, indicating an additional target of moenomycin, which is involved in cell separation. DCAP was found to interfere with septum formation and CWBM organization, suggesting a PGS-inhibiting mechanism of action. Additionally, the impact of several PGS-targeting antibiotics on the transmembrane potential was investigated and the interaction of the S. aureus heme-transporter and virulence factor IsdF with the fluid membrane microdomain scaffold protein FloA was examined.
Similar to the knowledge gap for how antibiotics kill pathogens, not much is known about the mechanisms of action and ecological roles of the many antimicrobial agents produced by members of the human microbiome, despite its clearly established role in health and infection. In this work, cellular effects of the epilancin A37 from a human nasal Staphylococcus epidermidis isolate were investigated using the model organism Corynebacterium glutamicum. Staphylococci and corynebacteria constitute key genera of the nasal microbiome, and production of A37 was found to convey an advantage to S. epidermidis in this inter-species competition. A37 was found to enter the corynebacterial cytoplasm without impairing the cell membrane in a partially transmembrane dependent manner. Upon cytoplasmic accumulation, A37 was found to induce the formation of intracellular membrane vesicles, which were found to be linked to antibacterial activity. Thus, this work provides evidence for a microbiome shaping effect of epilancin A37 and reveals that A37 kills corynebacteria with an intricate and unique mechanism of action
Attenuation and Velocity of Ultrasound Near the Critical Point of Gallium-Bismuth
No full textTitle: Attenuation and Velocity of Ultrasound Near the Critical Point of Gallium-Bismuth, Author: Manfred P. Puls, Location: ThodeAttenuation measurements were performed on a liquid Ga-Bi mixture above its miscibility gap and at the frequencies 16.6, 25.5, 37.6 and 49.7 MHz. The attenuation measurements were made over a composition range from 0.20 to 0.75 weight-fraction Bismuth and in the temperature range 0.3 to 9.9°C above the critical temperature of the mixture. For a mixture at the critical composition, attenuation measurements were also made 27.2°C above the critical temperature. The velocity of sound was measured at 25.5MHz and at each of the above temperature and composition points. The critical temperature and composition of the Ga-Bi system have been determined to improve accuracy as 263.1°C and 0.60 weight-fraction Bismuth, respectively. The attenuation results have been tested against current theories and these theories have been subject to critical analysis.ThesisDoctor of Philosophy (PhD
Estimating input allocation for farm supply models
No full textWhen building an economic model for supply analysis the aim is to model a decision making process of one or more agents which fits the observed practice as good as possible. Hereby the modeller is often confronted with incomplete information about the production process; particular crop specific input data are rarely available. The problem of defining activity related technology inputs coefficients is not new. A good deal of literature comes from the mathematical programming perspective, where input coefficients were estimated using a standard linear regression function to fully represent the mathematical program. However this approach is a pure technical device and may result in an inconsistent model. The author of the paper wants to investigate whether it is possible, employing proper estimation techniques, to simultaneously estimate all unknown coefficients of a mathematical farm supply model. This includes the estimation of parameters of the non linear cost function, used to calibrate and catch the simulation behaviour and the crop specific input coefficients. It is shown that a simultaneous estimation of all parameters improves the goodness of fit of the estimated parameters and that such an approach is technically feasible.farm supply model, input allocation, entropy, HDP, Research Methods/ Statistical Methods,
Supporting information file–database excel sheet “Insights into permanent pacemaker implantation following TAVR”.
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