71 research outputs found
Origins and functions of poetry in the lyrical works of Ales Barski
No full textЛірыка А. Барскага шматтэмная. Асэнсаванне эстэтычнай праблематыкі займае ў ёй не апошняе месца. Вытокі паэзіі ўвогуле А. Барскі бачыць у жыц-ці, а сваёй паэзіі – у прыгажосці навакольнай прыроды і ў помніках культу-ры, што стымулююць яго творчую актыўнасць. Лірыка А. Барскага аўтапсі-халагічная, лірычны герой паэта – асоба, духоўна блізкая аўтару. А. Барскі высока ацэньвае праўдзівасць і шчырасць аўтара-творцы. Спектр функцый паэзіі, з пункту гледжання А. Барскага, шырокі. Паэт вылучае сярод іх такія функцыі, як абуджэння чалавечай фантазіі, рэпрэзентацыі рэчаіснасці, ацэ-начную, мнеманічную і герменеўтычную, а таксама арыгінальную функцыю – функцыю захавання чалавекам маладосці ў працэсе творчасці.Liryka A. Barskiego jest różnotematyczna. Zrozumienie zagadnień estetycznych jest jednym z ważnym aspektów interpretacyjnych. A. Barski źródła poezji upatruje w życiu, a swojej w pięknie otaczającej przyrody i zabytków kultury, które stymulują twórczość. Liryka A. Barskiego jest autopsychologiczna, podmiot liryczny to osoba bliska duchowo autorowi. A. Barski docenia prawdziwość i szczerość autora-twórcy. Zakres funkcji poezji z punktu widzenia A. Barskiego jest szeroki. Poeta wyróżnia takie funkcje, jak rozbudzanie ludzkiej wyobraźni, reprezentowanie rzeczywistości, ewaluacyjne, mnemoniczne i hermeneutyczne, a także funkcję oryginalną – funkcję zachowania młodości człowieka w procesie twórczym.A. Barski's lyrical works approach different themes. The understanding of aesthetic issues is not the least important among them. A. Barski sees the origins of poetry in general in life, and bases his own poetry on the beauty of the surrounding nature and the cultural monuments that stimulate his creative activity. A. Barski's poems are autopsychological, that is to say, the poet's lyrical hero is spiritually close to the author. A. Barski appreciates the truthfulness and sincerity of the author-creator. The range of functions of poetry, from the point of view of A. Barski, is wide. The poet singles out such functions as the function of awakening the human imagination, the representation of reality, evaluation, mnemonics and hermeneutics, as well as the original poetic function – the function of preserving youth in the creative process
X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons
No full textTransition metals have been suggested to play a pivotal role in the pathogenesis of Parkinson's disease. X-ray microscopy combined with a cryogenic setup is a powerful method for elemental imaging in low concentrations and high resolution in intact cells, eliminating the need for fixation and sectioning of the specimen. Here, we performed an elemental distribution analysis in cultured primary midbrain neurons with a step size in the order of 300 nm and ~ 0.1 ppm sensitivity under cryo conditions by using X-ray fluorescence microscopy. We report the elemental mappings on the subcellular level in primary mouse dopaminergic (DAergic) and non-DAergic neurons after treatment with transition metals. Application of Fe(2+) resulted in largely extracellular accumulation of iron without preference for the neuronal transmitter subtype. A quantification of different Fe oxidation states was performed using X-ray absorption near edge structure analysis. After treatment with Mn(2+) , a cytoplasmic/paranuclear localization of Mn was observed preferentially in DAergic neurons, while no prominent signal was detectable after Mn(3+) treatment. Immunocytochemical analysis correlated the preferential Mn uptake to increased expression of voltage-gated calcium channels in DAergic neurons. We discuss the implications of this differential elemental distribution for the selective vulnerability of DAergic neurons and Parkinson's disease pathogenesis
Plasmids containing NRSE/RE1 sites enhance neurite outgrowth of retinal ganglion cells via sequestration of REST independent of NRSE dsRNA expression
No full textRepressor element-1 silencing transcription factor (REST) is a transcriptional repressor of neuron-specific genes that binds to a conserved DNA element, the neuron restrictive silencer element (NRSE/RE1). Interestingly, increased REST activity is found in several neurological diseases like Huntington's disease and cerebral ischemia. Recently, it was shown that NRSE dsRNA, a double-stranded non-coding RNA can bind to REST during a defined period of neuronal differentiation, and thereby changes REST from a transcriptional repressor to an activator of neuron-specific genes. Here, we analyzed the effects of NRSE dsRNA expression in primary retinal ganglion cells. We found that NRSE dsRNA expression vectors significantly enhance neurite outgrowth even when axonal degeneration is induced by neurotrophin deprivation. Transfection of HEK cells with NRSE dsRNA-expressing vectors altered their morphology leading to the formation of thin processes and induced the expression of neurofilament-68. Surprisingly, control vectors containing REST-binding sites, but not expressing NRSE dsRNA, resulted in the same effects, also in the retinal ganglion cell model. Reporter assays and retention of REST in the cytoplasm with a labeled NRSE/RE1-containing plasmid incapable of entering the nucleus suggest that sequestration of REST in the cytoplasm is the reason for the observed effects. No evidence for a biological function of NRSE dsRNA could be found in these models. We conclude that sequestration of REST leads to enhanced neurite outgrowth in retinal ganglion cells and that an increased activity of REST, as it is found in several neurodegenerative diseases, can be effectively modulated by sequestration of REST with plasmids containing NRSE/RE1 sites
25 years after transformation: changes in spatial distribution of production activities in the case study of Wroclaw, Poland
No full textBook of proceedings: Annual AESOP Congress, Definite Space – Fuzzy Responsibility, Prague, 13-16th July, 2015In the post-industrial, free-market economy, the ability of spatial planning to truly influence the location choices of business owners is limited, while the vast majority of means of production are in non-public hands. On top of that, coordinating spatial policies and decisions between administrative entities is a major challenge in numerous places in Europe. This paper offers a convenient case study of a medium-sized European city (Wroclaw, Poland) and an analysis of the spatial management complication which has observable consequences for the spatial structure and economic functioning of the city. The paper examines the situation through the lens of production and manufacturing activities (with a cautious approach to the term industry). The case is analysed in two inseparable ways: spatial and economic; parallel to that, the discussion is developed on the issue of the interconnection of policymaking in the metropolitan area (the city vs its surrounding rural communes). the changes in employment in subsequent sectors of the metropolitan area in the 25 years since the political transformation of Poland while keeping an eye on the physical, spatial changes of the aforementioned metropolitan area. The secondary output of the paper is outlining the suburbanisation processes of large Polish cities, however as seen not from the most frequently presented perspectives (such as housing or transportation), but from a more economy- and spatial responsibility-focused one.Published Versio
25 years after transformation: changes in spatial distribution of production activities in the case study of Wroclaw, Poland
Get PDFBook of proceedings: Annual AESOP Congress, Definite Space – Fuzzy Responsibility, Prague, 13-16th July, 2015In the post-industrial, free-market economy, the ability of spatial planning to truly influence the location choices of business owners is limited, while the vast majority of means of production are in non-public hands. On top of that, coordinating spatial policies and decisions between administrative entities is a major challenge in numerous places in Europe. This paper offers a convenient case study of a medium-sized European city (Wroclaw, Poland) and an analysis of the spatial management complication which has observable consequences for the spatial structure and economic functioning of the city. The paper examines the situation through the lens of production and manufacturing activities (with a cautious approach to the term industry). The case is analysed in two inseparable ways: spatial and economic; parallel to that, the discussion is developed on the issue of the interconnection of policymaking in the metropolitan area (the city vs its surrounding rural communes). the changes in employment in subsequent sectors of the metropolitan area in the 25 years since the political transformation of Poland while keeping an eye on the physical, spatial changes of the aforementioned metropolitan area. The secondary output of the paper is outlining the suburbanisation processes of large Polish cities, however as seen not from the most frequently presented perspectives (such as housing or transportation), but from a more economy- and spatial responsibility-focused one.Published Versio
The symbolism of the Light and Sun in the poetry of Belarusian Literary Association “Belavezha”
No full textBeata Siwek, LublinДадзены артыкул прысвячаецца сiмволiцы святла i сонца ў творчасцi
паэтаў Беларускага лiтаратурнага аб’яднання “Белавежа” – Алеся Барскага,
Яна Чыквiна i Надзеi Артымовiч. Ад тэарэтычных вывадаў, што адносяцца
да сiмволiкi святла, аўтар артыкула пераходзiць да аналiзу выбраных паэтычных твораў, на аснове якiх свярджае, што сонечна-светлая сiмволiка ў паэзii
«белавежцаў» амаль заўсёды звязана з тым, што духоўнае i боскае. Асабiстыя
перажываннi пераплятаюцца звычайна з гiсторыяй i фiласофiяй, а фiзiчны свет
арганiчна звязаны са светам псiхiчным.This article is about the symbolism of the Light and Sun in the poetry of Aleś
Barski, Jan Czykwin and Nadzieja Artymowicz, who belong to the Belarusian Literary Association “Belavezha”. From theoretical arguments the author proceeds to
the analysis of selected poems, and concludes that symbolism of the Light and Sun
in this poetry is almost always associated with the spiritual and divine. Personal
experience is linked with the history and philosophy whereas the physical world is
connected with the spiritual world.5334
Skaza wolności, piętno autokreacji. Nieludzki ciężar samostwarzania się podmiotu w antropologii romantycznej
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Announcing the Winner of the 2018 Maimonides Best Published Original Research Prize
No full textI am pleased to announce that the winner of the 2018 Maimonides Best Published Original Research Prize is Dr. Louise Kezerle, the first author of the paper entitled, “A Population-based Study of Peripartum Cardiomyopathy in Southern Israel: Are Bedouin Women a New High-risk Group?“ with co-authors Iftach M. Sagy, Leah Shalev, Offer Erez, and Leonid Barski
Industrial heritage and post-industrial situation in the post-transformation era in Lower Silesia (Poland)
Get PDFThis descriptive paper outlines the post-industrial setting and industrial heritage in both a concrete case – south-western Poland – and some general respects, with the aim of contributing to the available knowledge about the contemporary post-industrial areas in Central Eastern Europe. To produce such an outline and to offer such a contribution, the paper offers an overview of the changes that happened in Poland since the transformation of 1989/90 with the special focus put on the industrial sector in the small- and medium-sized towns in the south-western border region of Poland. Moreover, the paper describes how the political and economic changes have impacted industry in Poland immediately after the transformation, as well as how the evolution of the political and economic situation has been shaping the industrial sector along the years until today. Further, to solidify the broad background of post-industrial regions, the paper touches upon topics that are more specific and interconnected: location of industry, employment rate changes, regional development policies, local development inequalities, and vocational schooling system. The most specific descriptions in the paper focus on the industrial heritage in the towns and cities in the region of Lower Silesia. Apart from reviewing the industrial history of Poland and of the selected western regions, this paper looks into the future by commenting on the transition between the so-called 2.0, 3.0, and 4.0 industry phases and discusses whether small- and medium-sized towns in the Polish border areas are able to become connected to the future industrial network
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