21 research outputs found
Determinants of vaccine coverage and timeliness in a northern Pakistani village
No full textFunding: Funding was provided by the Pakistan US S&T Cooperative Agreement between the Pakistan Higher Education Commission (HEC) (No.4-421/PAK-US/HEC/2010/955, grant to the Karakoram International University) and US National Academies of Science (Grant Number PGA-P211012 from NAS to the Fogarty International Center). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are deeply indebted to the mothers and families who participated in these projects and the dedicated project staff. Study staff: Gulab Jan, Zohra Bano, Mobina Bano, Gul Nasreen, Mehtab Bano, Kaniz Fatima, Iqbal Bano, Dil Roz, Nazara, Ghazala, Nasima Begum, Alia Rani, Mehwish Hakeem, Rubina, Sameena, Zevar Jan, Sunaira, Resham Jan. FIC: Assis Jahan, Wasiat Shah. Karakoram International University: Khalil Ahmed, Arif Hussain, Mirza Jibran, Asif Hussain. Editorial assistance was kindly provided by Stacey Knobler, Jessica Seidman, Stephanie Richard and David Spiro. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the U.S. National Institutes of Health or Department of Health and Human Services.Peer reviewe
Isabelle Bell to Susan Niemcewicz, December 23, 1800
No full textIsabelle Bell wrote to Susan U. Niemcewicz in Elizabethtown, New Jersey. Bell expressed her disappointment in not receiving a line from Susan. She sent Bell Lucretia Rephans subscription epistle, but Susan refrained from writing a letter to her. Bell did not execute any of Susan’s commissions in New York because her time there was short. Miss Resham heard that Mr. B Livingston told his sister, Mrs. J. Livingston that he would offer Bell a salary to live in his house and take charge of his children’s education. Asked if Susan what she thought of her being an author and if Susan would subscribe to a small volume that may have the good fortune to rival the poems of the immortal Scarron.https://digitalcommons.kean.edu/lhc_1800s/1143/thumbnail.jp
Sensor development for a nano-satellite
No full textThis report presents the development of a magnetic sensor for use onboard a
nano-satellite; it would form one of the modules in the Altitude Determination
& Control System (ADCS). The magnetic sensor measures the intensity of
magnetic field for the purpose of providing magnetic heading. Through this
project, a prototype was assembled and tested on a breadboard level and
later, fabricated into a printed circuited board (PCB). The magnetic sensor
was developed to create a low cost standard for satellite construction. It is
based on Honeywell’s HMC1022, which uses the magnetoresistive
technology for magnetic field detection and chosen due to its small size, low
power and relatively low cost.
The development of the magnetic sensor will be described in stages and how
it functions, together with results obtained from the testing are thoroughly
explained. Two main analyses were carried out to illustrate the
characteristics of the prototype circuit with respect to the HMC1022
characteristics; the orthogonality test and the linearity test. In the
orthogonality test, the prototype output voltages are analyzed for a 90° phase
difference between the outputs of the HMC1022 sensors. In the linearity test,
the sensor sensitivity of the prototype was obtained by referencing the
prototype output voltage readings against HMR3000’s magnetic field
readings, over a range of ±1 gauss and with the results obtained; a heading
formulation was derived to calculate the magnetic heading from a voltage
reading.
In addition, this report also highlights the challenges and problems
encountered by the author in the course of the project and the steps taken to
overcome those issues.Bachelor of Engineerin
PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons
No full textSummaryThe fidelity of RNA splicing is maintained by a network of factors, but the molecular mechanisms that govern this process have yet to be fully elucidated. We previously found that TDP-43, an RNA-binding protein implicated in neurodegenerative disease, utilizes UG microsatellites to repress nonconserved cryptic exons and prevent their incorporation into mRNA. Here, we report that two well-characterized splicing factors, polypyrimidine tract-binding protein 1 (PTBP1) and polypyrimidine tract-binding protein 2 (PTBP2), are also nonconserved cryptic exon repressors. In contrast to TDP-43, PTBP1 and PTBP2 utilize CU microsatellites to repress both conserved tissue-specific exons and nonconserved cryptic exons. Analysis of these conserved splicing events suggests that PTBP1 and PTBP2 repression is titrated to generate the transcriptome diversity required for neuronal differentiation. We establish that PTBP1 and PTBP2 are members of a family of cryptic exon repressors
Transmission electron microscopy of Panc-1 cells treated with 67 μM/L gold nanoparticles
No full textPanel 1: 2 minutes of external radiofrequency (RF) field treatment. Note loss of nuclear stability and prominent vacuolization. Panel 2: No RF treatment. Nuclear integrity and normal appearing organelles.<p><b>Copyright information:</b></p><p>Taken from "Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells"</p><p>http://www.jnanobiotechnology.com/content/6/1/2</p><p>Journal of Nanobiotechnology 2008;6():2-2.</p><p>Published online 30 Jan 2008</p><p>PMCID:PMC2276230.</p><p></p
Thermographic results of heating of solutions of gold nanoparticles (GNPs) exposed to external radiofrequency (RF) fields at different RF generator power outputs
No full textPanel A: Graphic depiction of heating rate of deionized water with increasing concentrations of GNPs treated at 200 W of power. B. RF treatment at 400 W of power. C. RF treatment at 600 W of power. D. RF treatment at 800 W of power. Heating curves which conclude prior to 300 seconds are indicative of specimen boiling.<p><b>Copyright information:</b></p><p>Taken from "Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells"</p><p>http://www.jnanobiotechnology.com/content/6/1/2</p><p>Journal of Nanobiotechnology 2008;6():2-2.</p><p>Published online 30 Jan 2008</p><p>PMCID:PMC2276230.</p><p></p
Propidium Iodide-Fluorescent Activated Cell Sorting (PI-FACS) representative graphs
No full textEach sample from one minute radiofrequency (RF) treatment with and without gold nanoparticles (GNPs) at 67 μM/L. Panel A: Hep 3B human hepatocellular cancer cells control with DMEM; Panel B: Hep 3B GNPs; Panel C: Panc-1 human pancreatic cancer cells control with DMEM; Panel D: Panc-1 GNPs.<p><b>Copyright information:</b></p><p>Taken from "Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells"</p><p>http://www.jnanobiotechnology.com/content/6/1/2</p><p>Journal of Nanobiotechnology 2008;6():2-2.</p><p>Published online 30 Jan 2008</p><p>PMCID:PMC2276230.</p><p></p
U.S. cereal rye winter cover crop growth database
No full textPlease see publication for complete list of co-authors. This article was originally published in Scientific Data. The version of record is available at: https://doi.org/10.1038/s41597-024-02996-9. © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States. The dataset includes a total of 5,695 cereal rye biomass observations across 208 site-years between 2001–2022 and encompasses a wide range of agronomic, soils, and climate conditions. Cereal rye biomass values had a mean of 3,428 kg ha−1, a median of 2,458 kg ha−1, and a standard deviation of 3,163 kg ha−1. The data can be used for empirical analyses, to calibrate, validate, and evaluate process-based models, and to develop decision support tools for management and policy decisions.This study was made possible by funding from USDA Natural Resources Conservation Service Conservation Innovation Grants [award no. # NR21-13G022], USDA National Institute of Food and Agriculture, Agriculture and Food Research Initiative’s Sustainable Agricultural Systems Coordinated Agricultural Project [award no. 2019-68012-29818], USDA National Institute of Food and Agriculture, Hatch Project [award no. MD-ENST-22008], USDA National Institute of Food and Agriculture, Agriculture and Food Research Initiative’s Water Coordinated Agricultural Project [award no. 2018-68011-28372], USDA Area-Wide Pest Management [Project Number 8042-22000-16600D], Wisconsin Fertilizer Research Council project: 276-14, multiple state agricultural experiment stations, and the Hatch program of the National Institute of Food and Agriculture, US Department of Agriculture
Social Media Use and Wellbeing: A Systematic Review and Meta-Analysis
No full textBackground
Social media provides a digital platform for people to communicate with one another. When using social media, users frequently use web-based apps such as social networking sites. Each social networking site employs a distinct technology and offers a distinct subjective experience. Since the introduction of new technological means such as fast internet, app development, advanced artificial intelligence-based features, and digital gadgets, social media usage has reached an all-time high. In the recent two decades, there has been a surge in the use of social media platforms such as Facebook, WhatsApp, Twitter, and other comparable online platforms, for which different correlates have been discovered. Excessive, active or passive SMU has been related to boredom, social overload, fear of missing out, technostress, impulsivity in monitoring or answering to messages, social cohesion, and addiction, to mention a few.
It has been established that the use of social media in its many forms effects how people behave, feel, and think.
There is a growing interest in researching the impact and consequence of regular and problematic social media use on users' mental health. Furthermore, earlier research yielded inconsistent results, and no comprehensive meta-analysis of the relationship between social media use and wellbeing was conducted, taking into account different types of wellbeing and the entire population. Given the empirical data, study on how social media use affects wellbeing is critical for informing future policymakers, professionals, and public health attitudes.
As a result, the current study will conduct a systematic review and meta-analysis to investigate the relationship between social media consumption and wellbeing and its subtypes. The proposal adheres to all of the standards required to carry out the meta-analysis. PRISMA standards and the PICO framework are examples, as are crucial assessments such as the risk of bias assessment of each study to be included.
Objectives
To estimate the pooled correlation coefficient between social media use and subjective well-being, taking into account the source of heterogeneity.
To estimate the pooled correlation coefficient between social media use and psychological well-being, taking into consideration the causes of heterogeneity.
To study the effect of predictor variables such as age, gender distribution, or sample size on the relevant pooled correlation.
Search strategy: To discover relevant records, five electronic databases (PubMed, Scopus, ProQuest, Google Scholar, and Web of Science) will be employed. Along with the advanced search using Boolean operators, records will be vetted systematically using the PRISMA chart and framework. An Excel sheet will be used to extract and synthesize the data. When missing values are detected, the author is notified; if they do not answer, the value is imputed at the time of analysis.
All correlations and sample sizes would be translated into Fisher's z scores for meta-analysis using the correlation (r-method) meta-analysis.
This would be accomplished with the (meta, dmetar, metafor, and tydiverse) software packages in R-studio version 4.0.2. The overall forest plot, pooled estimated correlation effect size, confidence interval, prediction interval, heterogeneity measure, funnel plot, Egger's regression-based test (for publication bias), and meta-regression would be key statistics. In the discussion part, all of the results will be summarized in figures and tables, interpreted, and discussed.
The appendix or separate supplements file would contain the primary data file, risk of bias assessment, and any other relevant information (if any)
Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan : Evidence from two longitudinal cohort studies 15 years apart
No full textFunding Information: Study 1 was funded through the Applied Diarrheal Disease Research Program at Harvard Institute for International Development with a grant from USAID (Project 936–5952, Cooperative Agreement # DPE-5952-A-00-5073-00), and the Aga Khan Health Service, Northern Areas and Chitral, Pakistan. Study 2 was funded by the Pakistan US S&T Cooperative Agreement between the Pakistan Higher Education Commission (HEC) (No.4–421/PAK-US/HEC/2010/955, grant to the Karakoram International University) and US National Academies of Science (Grant Number PGA-P211012 from NAS to the Fogarty International Center). The funding bodies had no role in the design of the study, data collection, analysis, interpretation, or writing of the manuscript. Publisher Copyright: © 2020 The Author(s).Peer reviewe
