1,720,972 research outputs found
Spinocerebellar Ataxia Type 35 Caused by a New TGM6 Variant: Video Documentation of a German Family
No full textThe effect of inadvertent systemic hypothermia after mechanical thrombectomy in patients with large-vessel occlusion stroke
Full text linkBackground and aimsPostinterventional hypothermia is a frequent complication in patients with large-vessel occlusion strokes (LVOS) after mechanical thrombectomy (MT). This inadvertent hypothermia might potentially have neuroprotective but also adverse effects on patients’ outcomes. The aim of the study was to determine the rate of hypothermia in patients with LVOS receiving MT and its influence on functional outcome.MethodsWe performed a monocentric, retrospective study using a prospectively derived databank, including all LVOS patients receiving MT between 2015 and 2021. Predictive values of postinterventional body temperature and body temperature categories (hyperthermia (≥38°C), normothermia (35°C–37.9°C), and hypothermia (<35°C)) on functional outcome were analyzed using multivariable Bayesian logistic regression models. Favorable outcome was defined as modified Rankin Scale (mRS) ≤3.ResultsOf the 480 included LVOS patients with MT (46.0% men; mean ± SD age 73 ± 12.9 years), 5 (1.0%) were hyperthermic, 382 (79.6%) normothermic, and 93 (19.4%) hypothermic. Postinterventional hypothermia was significantly associated with unfavorable functional outcome (mRS > 3) after 90 days (OR 2.06, 95% CI 1.01–4.18, p = 0.045). For short-term functional outcome, patients with hypothermia had a higher discharge NIHSS (OR 1.38, 95% CI 1.06 to 1.79, p = 0.015) and a higher change of NIHSS from admission to discharge (OR 1.35, 95% CI 1.03 to 1.76, p = 0.029).ConclusionApproximately a fifth of LVOS patients in this cohort were hypothermic after MT. Hypothermia was an independent predictor of unfavorable functional outcomes. Our findings warrant a prospective trial investigating active warming during MT
Flow diverter treatment of ruptured basilar artery perforator aneurysms: a multicenter experience
Full text linkPurpose Ruptured basilar artery perforator aneurysms (BAPAs) represent a very rare cause of subarachnoid hemorrhage and an under-reported subtype of cerebral aneurysm. There is no consensus for the optimal treatment strategy (conservative vs. surgical vs. various endovascular approaches). We aim to present a multicenter experience of BAPA treatment using flow-diverter (FD) stents. Methods At five tertiary neurovascular centers, all cases of ruptured BAPAs treated by FD were retrospectively collected. Baseline imaging and clinical characteristics, complications, as well as early and long-term angiographic and clinical outcome (mRS) were analyzed. Results Eighteen patients (mean age, 57 years; SD, +/- 10.7 years) with acute SAH related to a BAPA were treated using 18 FD stents. Aneurysms were detected on initial imaging study in 28%; delayed diagnosis was triggered by clinical deterioration due to rebleeding in 15%. No rebleeding after FD was seen, 28% developed FD-related ischemic complications. At long term (n = 16), overall mortality was 13% (2/16), and favorable outcome (mRS 0-2) was 81% (13/16). All BAPAs (n = 13) were completely occluded at long-term angiographic follow-up. Conclusion In our multicenter experience, FD treatment of ruptured BAPAs appears to have comparable safety and efficacy outcomes to FD treatment of other ruptured posterior circulation aneurysms as well as to the conservative management of BAPAs. This treatment strategy for a ruptured BAPA achieved a high rate of angiographic occlusion and favorable clinical outcome; however, as the conservative management also seems to offer similar clinical outcomes an individualized treatment decision is warranted. Future prospective studies comparing both approaches are required
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Spezifischer Einfluss multipotenter Stromazellen auf die Zytostatikasensitivität kolorektaler Karzinomzellen
Full text linkMultipotente Stromazellen (MSC) nehmen am Aufbau des Tumorstromas teil und gelten als therapieresistent. In der vorliegenden Arbeit wurde in vitro gezeigt, dass MSC eine spezifische Zytostatikaresistenz von kolorektalen Karzinomzellen (CRC) gegenüber 5-Fluorouracil (5-FU) vermitteln, im Vergleich zu weiteren Stromazellen. Dies erfolgt teils über lösliche Faktoren der Stromazellen und Suppression des 5-FU-bedingten Zellzyklusarrests für die CRC-Zelllinie HCT8. MSC fördern darüber hinaus das Wachstum von CRC-Zellen im 2D-Modell und 3D-Sphäroidmodell und vermitteln morphologische Veränderungen von CRC-Zellen, welche bei der epithelial-mesenchymalen Transition vorkommen. Die Identifikation der beteiligten Mechanismen und die therapeutische Inhibition dieser birgt daher die Möglichkeit Tumorzellen gegenüber Therapeutika zu sensitivieren und somit den Erfolg von Tumortherapien zu steigern.Multipotent stromal cells (MSC) participate in forming the tumor stroma and are regarded as therapy-resistant. In this present work it has been shown in vitro, that MSC promote specific drug resistance of colorectal carcinoma (CRC) cells against 5-fluorouracil (5-FU),compared to other stromal cells. This is partially due to soluble factors of the stromal cells and suppression of the 5-FU-induced cell cycle arrest of the CRC cell line HCT8. Furthermore MSC support the growth of CRCcells in the 2D model and 3D spheroid model, and mediate morphological changes of CRC cells that occur in the epithelial-mesenchymal transition. The identification of the involved mechanisms and their therapeutic inhibition therefore bears the potential to sensitize tumor cells to therapeutics and thus to increase the success of tumor therapies.vorgelegt von Ala Jamou
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The malignant stroke indicator is an early indicator of malignant ischemic stroke requiring decompressive hemicraniectomy
Full text linkDecompressive craniectomy (DHC) can prevent mortality in patients with malignant ischemic stroke. However, no clear criteria have been established to early identify patients, who will develop malignant stroke requiring DHC. In this retrospective observational study, a large patient cohort with ischemic stroke treated between 2010 and 2021, was analyzed. Clinical and radiological parameters were analyzed. Univariate and multivariate regression analyses were performed to identify the parameters to be included in the score. A cohort of 534 patients was included. A malignant stroke indicator (MSI) score was created including age < 70 years with 7 points, midline shift with up to 6 points, unsuccessful recanalization (TICI < 2b) with 6 points, basal cistern effacement with 4 points, and CBV ASPECTS < 6 with 3 points assigned. A MSI score with a cutoff value of 9 showed a high discrimination power concerning the need for DHC (AUC 0.90, p < 0.0001). Patients with MSI-score ≥ 9 had a 22-fold higher probability of needing DHC (odds ratio 22.90, p < 0.0001). The MSI score is a promising tool to predict the need for DHC in patients at risk for developing a malignant stroke and needs to be validated in external cohorts
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