7 research outputs found

    SITC/iSBTc cancer immunotherapy biomarkers resource document: online resources and useful tools - a compass in the land of biomarker discovery

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    Recent positive clinical results in cancer immunotherapy point to the potential of immune-based strategies to provide effective treatment of a variety of cancers. In some patients, the responses to cancer immunotherapy are durable, dramatically extending survival. Extensive research efforts are being made to identify and validate biomarkers that can help identify subsets of cancer patients that will benefit most from these novel immunotherapies. In addition to the clear advantage of such predictive biomarkers, immune biomarkers are playing an important role in the development, clinical evaluation and monitoring of cancer immunotherapies. This Cancer Immunotherapy Resource Document, prepared by the Society for Immunotherapy of Cancer (SITC, formerly the International Society for Biological Therapy of Cancer, iSBTc), provides key references and online resources relevant to the discovery, evaluation and clinical application of immune biomarkers. These key resources were identified by experts in the field who are actively pursuing research in biomarker identification and validation. This organized collection of the most useful references, online resources and tools serves as a compass to guide discovery of biomarkers essential to advancing novel cancer immunotherapies

    Pioneering the trail of cancer immunotherapy

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    Presence 2021

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    Mary Ann B. Miller Lois Roma-Deeley Marjorie Maddox Gregory Orfalea Jeannine M. Pitas Reginald Baylor Joseph A. Brown, S.J. Ashaq Hussain Parray Barbar Crooker Dante Di Stafano Linda Nemec Foster Mary Ladany Kelli Russell Agodon Sarah Allen Lisa Ampleman Matthew J. Andrews Devon Balwit Charles Baudelaire Lisa Breger Ronda Piszk Broatch Mary Buchinger Justin Carisio Katy Carl Sean M. Conrey Robert Cording Sarah Cortez Zach Czaia Cortney Davis John F. Deane CX Dillhunt Lynn Domina Christina Ellsberg CJ Giroux George Guida Maryanne Hannan Marc Harshman Matthew E. Henry Lou Ella Hickman, IWBS John Hodgen Juan Ramon JImenez Kirsten Kinnell Leonard Kress Kristina Kryukova Gerry LaFemina K. T. Landon Sheree La Puma Sue Fagalde Lick James Littwin V. P. Loggins Jimmy Long Dan MacIsaac Annita Costa Malufe John Martone Jane McCafferty Megan McDermott Julio Martinez Mesanza Gabriela Mistral Theresa Monteiro J. P. Murphy Ann Neelon Colin Pope Rainer Maria Rilke Susan McLean James Owens Lisa Toth Salinas Nicholas Samaras Julia Samorodova J. D. Schraffenberger Martha Silano Katherine Smith Maria Terrone David Thoreen Daniel Tobin Cindy Veach Shanna Powlus Wheeler James Matthew Wilson Jessica Schnepp Mary Szybist Madeleine Mysko Carol Park Ned Balbo Kevin Brown Jeannine M. Pitas Sheryl St. Germain Michael P. Murphy Marion Goldstein Robert Cording Donna Dzurilla William Coleman Janet McCann Isak Bond Ryan Wilson Maryann Corbett Jessica Hooton Wilson Wendy Galgan Mia Schilling Grogan Janna Schledorn Julie L. Moore Carole Stone Laura Hogan Alan Berecka Janine Molinaro Bayer Owen Lewishttps://griffinshare.fontbonne.edu/presence/1004/thumbnail.jp

    the International Society for Biological Therapy

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    Guiding cancer immunotherapy from bench to bedside Review of the 25th annual scientific meeting o

    The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program

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    Abstract The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy. The society and its educational programs have become premier destinations for interaction and innovation in the cancer biologics community. For over a decade, the society has offered the Primer on Tumor Immunology and Biological Therapy of Cancer™ in conjunction with its Annual Scientific Meeting. This report summarizes the 2010 Primer that took place October 1, 2010 in Washington, D.C. as part of the educational offerings associated with the society's 25th anniversary. The target audience was basic and clinical investigators from academia, industry and regulatory agencies, and included clinicians, post-doctoral fellows, students, and allied health professionals. Attendees were provided a review of basic immunology and educated on the current status and most recent advances in tumor immunology and clinical/translational caner immunology. Ten prominent investigators presented on the following topics: innate immunity and inflammation; an overview of adaptive immunity; dendritic cells; tumor microenvironment; regulatory immune cells; immune monitoring; cytokines in cancer immunotherapy; immune modulating antibodies; cancer vaccines; and adoptive T cell therapy. Presentation slides, a Primer webinar and additional program information are available online on the society's website.</p

    Immuno-Oncology biomarkers 2010 and beyond: Perspectives from the iSBTc/SITC biomarker task force

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    Abstract The International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) hosted a one-day symposium at the National Institutes of Health on September 30, 2010 to address development and application of biomarkers in cancer immunotherapy. The symposium, titled Immuno-Oncology Biomarkers 2010 and Beyond: Perspectives from the iSBTc/SITC Biomarker Task Force, gathered approximately 230 investigators equally from academia, industry and governmental/regulatory agencies from around the globe for panel discussions and presentations on the following topics: 1) immunologic monitoring: standardization and validation of assays; 2) correlation of immunity to biologic activity, clinical response and potency assays; 3) novel methodologies for assessing the immune landscape: clinical utility of novel technologies; and 4) recommendations on incorporation of biomarkers into the clinical arena. The presentations are summarized in this report; additional program information and slides are available online at the iSBTc/SITC website.</p

    Review of the 25<sup>th </sup>annual scientific meeting of the International Society for Biological Therapy of Cancer

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    Abstract Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a scientific platform for ~500 attendees to exchange cutting-edge information on basic, clinical, and translational research in cancer immunology and immunotherapy. The meeting included keynote addresses on checkpoint blockade in cancer therapy and recent advances in therapeutic vaccination against cancer induced by Human Papilloma Virus 16. Participants from 29 countries interacted through oral presentations, panel discussions, and posters on topics that included dendritic cells and cancer, targeted therapeutics and immunotherapy, innate/adaptive immune interplay in cancer, clinical trial endpoints, vaccine combinations, countering negative regulation, immune cell trafficking to tumor microenvironment, and adoptive T cell transfer. In addition to the 50 oral presentations and >180 posters on these topics, a new SITC/iSBTc initiative to create evidence-based Cancer Immunotherapy Guidelines was announced. The SITC/iSBTc Biomarkers Taskforce announced the release of recommendations on immunotherapy biomarkers and a highly successful symposium on Immuno-Oncology Biomarkers that took place on the campus of the National Institutes of Health (NIH) immediately prior to the Annual Meeting. At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network (CITN). In summary, the Annual Meeting gathered clinicians and scientists from academia, industry, and regulatory agencies from around the globe to interact and exchange important scientific advances related to tumor immunobiology and cancer immunotherapy.</p
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