66 research outputs found
An explicit expression for velocity profile in presence of secondary current and sediment in an open channel turbulent flow
No full textThe present study revisits the determination of vertical distribution of streamwise velocity in an open channel turbulent flow considering the effect of secondary current in the presence of sediment together with a concentration dependent settling velocity and von Karman constant κs. The work mainly modifies a previous study that introduced a lot of assumptions to obtain an analytical solution of the velocity distribution. The present study overcomes those assumptions in the model and though not fully analytical, attempts to present a semi-analytical solution that is explicit and in the form of a convergent series. Homotopy analysis method is used for this purpose and it is validated with numerical solution as well as with available laboratory data from the literature. How the secondary current and concentration dependent κs influence the velocity profile, is also discussed.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Topology of Disordered Networks and their Applications
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Topology of Disordered Networks and their Applications
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Solution to One-Dimensional Diffusion Equation with Concentration-Dependent Mixing Length
No full textEvaluation of Berlin-Frankfurt-Munster (BFM)protocols in Acute Lymphoblastic Leukemia and the role of Flow Cytometry in Minimal Residual Disease Monitoring: A Single Tertiary Centre Analysis from India.
No full textINTRODUCTION :
Acute lymphoblastic leukemia (ALL) is a malignant disease of immature lymphoid cells
proliferating at an uncontrolled rate with a block in its early stage of differentiation.(1) It has
been reported as one of the most common malignancy of the childhood, accounting for almost
25% of all pediatric tumours and about 80% of pediatric leukemia.(1,2) Its incidence shows a
bimodal peak, with the initial and the highest peak seen between 2 to 5 years of age and then a
continues decline in the incidence with increasing age till the age of 50 years, following which it
again shows a second peak.
AIMS AND OBJECTIVES : (1) To study the clinical profile of children and
adults diagnosed with acute lymphoblastic leukemia in our institute and their treatment
outcome, when treated with different BFM protocols. (2) To evaluate the clinical outcome
in adolescent patients with acute lymphoblastic leukemia between 15 - 20 years of age,
by using pediatric treatment regimens instead of adult regimens as currently used. (3) To
assess the role of minimal residual disease status monitoring by flow cytometry at time of
documenting remission, post induction phase of chemotherapy.
METHODOLOGY : For retrospective analysis of adult patients, we included all newly
diagnosed patients with acute lymphoblastic leukemia from January 2004 to February
2014. For adolescent patients, we compared adolescents treated by adult regimens from
January 2004 to June 2012 with those adolescents treated with pediatric regimens from
July 2012 to February 2014. We also compared standard and intermediate risk pediatric
patients treated with the non BFM 95 regimens from January 2004 to those receiving
BFM 95 based regimens from 2008. Lastly, since July 2012 we prospectively analyzed
the role of flow cytometry in assessing the minimal residual status at the end of induction
chemotherapy and compared the outcomes of those who tested positive with those tested
negative.
RESULTS : Among 455 adults analyzed, there were 331(72.7 %) standard risk and 124
(27.2 %) high risk adults. Median follow up duration was 65 months. There were 132
(29 %) relapses and 179 (39.3 %) deaths. The 5 year EFS was 50.1 ± 2.9 % and the 5-
year OS was 51.6 ± 2.9 %.
Among children with standard risk ALL, with an actuarial median follow up period of
25(1.5 - 65) months and 17(1- 64) months for those treated with the BFM 95 protocol and
those with the Non MTx/Non RT based study protocol; the three year event free survival
was 95 ± 4.9 % and 86.5 ± 6.5 % respectively. (P value= 0.391). Among children with
intermediate risk ALL, with an actuarial median follow up period of 27 (1 - 47) months
and 18 (1-116) months for those treated with the BFM 95 protocol and those with the
radiation (RT) based protocol; the two year overall survival was 96.9 ± 3.1 % and 85.6 ±
2.4 % respectively. (P value = 0.103) With an actuarial median follow up period of 7.7
(1 - 19) months and 18(1-118) months those treated with intermediate risk pediatric
protocol and the modified adult GMALL protocol; the one year event free survival was
82.3 ± 7.3 % and 75.9 ± 3.6 % respectively.(P value = 0.752) Among patients tested for
the minimal residual disease, with an actuarial median follow up of 7.7 (1-19) months,
the 6 months and 1 year EFS in MRD (-) cohort (n = 53) is 97.4 ± 2.6 %. With an
actuarial median follow up of 7.7 (1-13) months, the 6 months and 1 year EFS in MRD
(+) cohort (n = 16) is 75 ± 21.7 %. With a median follow up of 6 months, the 6 months
OS in MRD strongly (+) cohort (n = 6) is 20 ± 17.9 %. (P = 0.000)
CONCLUSION: Using the current modified GMALL and BFM 95 regimens in adults (≥
15 years) and children (>1<15 years), treatment outcomes were comparable to those
reported in the international literature. There was no significant difference as yet in the
BFM 95 and the non BFM 95 regimens. Using pediatric regimens in adolescent age
group (≥15 ≤ 20 years) did not reveal any significant difference in overall outcome as
compared to adult regimens. Though the follow up is short, pediatric regimens are
feasible in adolescents with minimal toxicity and there appears to be a trend towards
improvement in their outcomes with pediatric regimens. Using flow cytometry in
detecting minimal residual disease can significantly identify high risk patients and
improve their outcome by timely intensification
Solar Sail Trajectory Design for a Martian Moon Sample-return Mission
No full textWith a dedicated mission to the Martian moons, Phobos and Deimos, set to launch soon, there is a growing interest in further exploring these moons using low-thrust propulsion. This paper investigates the trajectory design for a sample-return mission from Deimos using fuel-free solar sail propulsion technology, aiming to maximize operational time near Deimos within a minimum permissible total mission duration. Time-optimal transfers between Earth and Deimos are sought by formulating and solving an optimal control problem using a direct pseudospectral method. Initial guesses for the direct method are generated by considering a patched circular restricted three-body problem (CR3BP) approximation and by searching for heteroclinic-like connections between the Sun-Earth and Mars-Deimos systems using the differential evolution algorithm. The obtained solution, with a maximum mission duration set to eight years based on the insights from initial guess generation, results in an optimal duration of stay at Deimos of 329 days with a mission duration of 7.7 years. Although the patched CR3BP approximation demonstrated valid transfer solutions for this study, it is deemed computationally inefficient for future trajectory designs for similar mission concepts targeting either only Phobos or both moons at once. Nevertheless, the trajectories obtained back and forth from Deimos are sufficiently optimal for a preliminary mission concept and validate the feasibility of achieving such a mission employing a solar sail.Aerospace Engineerin
An mSMART-based 5-probe high-risk FISH panel should suffice for early risk stratification in newly diagnosed multiple myeloma in a resource-limited setup
No full textAn improved approach of CBIR using Color based HSV quantization and shape based edge detection algorithm
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