459 research outputs found
Repurposing FDA approved drugs against monkeypox virus DNA dependent RNA polymerase: virtual screening, normal mode analysis and molecular dynamics simulation studies
No full textZoonotic monkeypox disease, caused by the double-stranded DNA monkeypox virus, has become a global concern. Due to the absence of a specific small molecule drug for the disease, this report aims to identify potential inhibitor drugs for monkeypox. This study explores a drug repurposing strategy using virtual screening to evaluate 1615 FDA approved drugs against the monkeypox virus DNA dependent RNA polymerase subunit A6R. Normal mode analysis and molecular dynamics simulation assessed the flexibility and stability of the target protein in complex with the top screened drugs. The analysis identified Nilotinib (ZINC000006716957), Conivaptan (ZINC000012503187), and Ponatinib (ZINC000036701290) as the most potential RNA polymerase inhibitors with binding energies of - 7.5 kcal/mol. These drugs mainly established hydrogen bonds and hydrophobic interactions with the protein active sites, including LEU95, LEU90, PRO96, MET110, and VAL113, and residues nearby. Normal mode analysis and molecular dynamics simulation confirmed the stability of interactions between the top drugs and the protein. In conclusion, we have discovered promising drugs that can potentially control the monkeypox virus and should be further explored through experimental assays and clinical trials to assess their actual activity against the disease. The findings of this study could lay the foundation for screening repurposed compounds as possible antiviral treatments against various highly pathogenic viruses
p27Kip1 and Tumors: Characterization of CDKN1B Variants Identified in MEN4 and Breast Cancer
No full textp27Kip1 is a key cell cycle gatekeeper governing the timing of Cyclin-dependent kinase (CDK) activation/inactivation and, consequently, cell proliferation. Structurally, the protein is largely unfolded, a feature that strongly increases its plasticity and interactors and enhances the number of regulated cellular processes. p27Kip1, like other intrinsically unstructured proteins, is post-translationally modified on several residues. These modifications affect its cellular localization and address p27Kip1 for specific interactions/functions. Several germline or somatic CDKN1B (the p27Kip1 encoding gene) mutations have been demonstrated to be associated with multiple endocrine neoplasia type 4 (MEN4), hairy cell leukemia, small-intestine neuroendocrine tumors, and breast and prostate cancers. Here, we analyzed the effect of four CDKN1B missense and nonsense mutations found in patients affected by MEN4 or cancers, namely, c.349C>T, p.P117S; c.397C>A, p.P133T; c.487C>T, p.Q163*; and c.511G>T, p.E171*. By transfecting breast cancer cell lines, we observed increased growth and cell motility for all the investigated mutants compared to wild-type p27Kip1 transfected cells. Furthermore, we discovered that the mutant forms exhibited altered phosphorylation on key residues and different localization or degradation mechanisms in comparison to the wild-type protein and suggested a possible region as crucial for the lysosome-dependent degradation of the protein. Finally, the loss of p27Kip1 ability in blocking cell proliferation was in part explained through the different binding efficiency that mutant p27Kip1 forms exhibited with Cyclin/Cyclin-dependent Kinase complexes (or proteins involved indirectly in that binding) with respect to the WT
Millenaire de la Mosquee-Universite d’el Azhar
No full textpage, Plate 1: History of Cairo and al-Azhar - plans of al-Azhar and surrounding area in 1940 and the 1000 years previou
Millenaire de la Mosquee-Universite d’el Azhar
No full textpage, Plate XII: rendering of a night celebration at al-Azhar after proposed works are complete
Optimalisasi Kemampuan Membaca untuk Meningkatkan Kemahiran Menulis Dalam Bahasa Mandarin Mahasiswa Prodi Tiongkok Universitas Al Azhar Indonesia
No full textLearning writing skills in Mandarin is often something that is feared and less desirable because of the level of difficulty, because it requires a learning method that can overcome the obstacles faced by learners in this proficiency. This research seeks to provide an alternative method of learning to write by optimizing students' reading abilities. By using a qualitative approach, the author tries to optimize the reading of Chinese texts in learning activities to improve students' writing skills. From the results of this study, it is known that by providing more reading input, students also have more knowledge regarding the topic of writing and its development, better vocabulary mastery and understanding of good writing methods/methods so that it has a positive impact on the development and improvement of writing skills of students in MandarinKeywords – Mandarin, Writing Skills, Reading Abilities, Optimizing.
Implementasi Konsep Perbuatan Baik dan Buruk di MA Al Azhar Citangkolo
No full textFrom the discussion above, related to the analysis of the Application of Good and Bad Deeds in MA Al Azhar Citangkolo carried out by the school in learning activities. Where the application of ethics and morals in everyday life is embodied in a disciplined attitude that is applied jointly to students, teachers, and employees, as well as all school stakeholders at MA Al Azhar Citangkolo Banjar City. The strategy in implementing moral education in developing character education at MA Al Azhar Banjar City is carried out in class. Evaluation of the results and process of implementing moral education in the development of character education at MA Al Azhar Banjar City, that evaluation of the implementation of moral education at the end of the semester and also every day in students' daily lives. Qualitative research methods, with a descriptive analytical approach the author uses in this study
The Intellectual Representative of the School of objective Criticism: Azhar Ghouri: مکتبۂ معروضی نقد ونظر کا فکری نمایندہ: اظہر غوری
No full textObject oriented approach of criticism has its roots in post continental philosophies based on perdiction and vision. Azhar Ghouri has strong advocacy for universalization of values and global adaptation of critical thinking styles. He believes in sublimity of Art and architecture regardless of classic or modern as a label for critical analysis. He believes in exploration of ideas and vision with insight in any piece of literature beyond its mechanical structure. Colonialism, exploitation, industrialisation, hunger, fear, shelter, peace and justice are controversial in global village according to A. G which needed to be reflected in art and literature in modes of individual’s interest. Author of this artical has explored gross root level realities and fundamental beliefs of object oriented approach in literary works of A.G. The agitation through pen has always been an eye opener initiative to stimulate the reader same has been highlighted by the author in the artical.
Reference:
Azhar Ghori ,do tehzibo ki dohri maanwiyat kay hamil afsanay,mazmoon mashmoola,jahan e rang o boo,az nayar aqbal alwi,Lahore,multi media,affairs,2005,s 7.
Azhar Ghori,Nazriyati murassa kaar afsaana nigar,Sami Ajaow,gair muratba,19 July,2023
Azhar Ghori,Takhliqi shaoor ki Shairi,Ghair muratba,2002.
Azhar Ghori,Awam dushman nizam ko badalnay ka muharak,,nukta nazer ,mutbuaa ,haft rooza,siraat ,2009.
Azhar Ghori,ghair mutboowa mazmmon,2021.
Azhar Ghori ,Tareikhi shasoor ki hamil shairi,ghair mutbuaa,16 junauary,2023.
Azhar Ghori,Sufaid jhoot,Dr uzma aziz khan kay shahkaar afsanchay,Lahore ,multi media affairs,2023,s.107
TOLERANSI PERSPEKTIF HAMKA DALAM TAFSIR AL-AZHAR
No full textThe aim of this research is to explain tolerance from Hamka\u27s perspective which the author found in Tafsir Al-Azhar. This paper finds the principles of tolerance in Hamka\u27s Tafsir Al-Azhar. Tafsir Al-Azhar is a commentary on Hamka\u27s work which focuses more on the adâbi ijtimâ\u27i interpretation style. This can be seen in the explanation in Tafsir Al-Azhar regarding the principles of tolerance, such as: Compassion and good behavior between religious communities (Q.S. al-Fâtihah/1: 1), freedom of religion (Q.S. al-Baqarah/2: 256; al-Kahfi/18: 29), Enable tolerance amidst diversity, (Q.S. al-Hujurât/49: 13, Mutual respect between religious communities, (Q.S. al-Baqarah/2: 62). This research uses an approach literature (library research). The research method used in this scientific work is qualitative research methods. As for the review of the study of the interpretation of the al-Quran, this research is classified as a variety of thematic interpretations or maudhû\u27î. The conclusion in this research is that tolerance Hamka in Tafsir Al-Azhar promotes the paradigm of tolerance between religious communities, that in social life there are various kinds of differences such as ethnicity, race, language, culture, customs and also religion. In facing these differences, a person must have an attitude of tolerance so that social life remains united and not divided. With an attitude of tolerance, a person can invite peace towards other religions and give freedom to followers of certain religions in choosing a religion according to their respective beliefs without any coercio
KONSEPTUALISASI AJARAN TASAWUF BUYA HAMKA DALAM TAFSIR AL-AZHAR
No full textABSTRAK Buya Hamka is a preacher and mufassir who spreads his
message through teaching modern Sufism, where modern
Sufism is a new breakthrough among Sufism developed by
Sufis. Buya Hamka also has a phenomenal work, namely Tafsir
Al-Azhar, which also contains modern Sufism teachings in his
interpretation. This journal aims to find out Hamka's conceptual
interpretation which is in synergy with Sufistic da'wah in the
practical application of Islamic da'wah. The method used in this
research is qualitative-descriptive with a content analysis
approach, namely the author attempts to study and analyze
whether there is a connection between the Sufistic verses in Al
Azhar's interpretation and the Sufism verses that he quotes in
his lecture. The findings from this study are that in Al-Azhar
Buya Hamka's tafsir explains more the meaning of the isyarah, while Buya Hamka's oral tafsir in his lecture looks different,
this can be seen from the verses which summarize verbally in
Buya Hamka's Sufism lecture, he quoted a verse from the Koran
and explained the meaning of the verse in accordance with its
natural meaning, which shows that Buya Hamka's oral
interpretation in his lecture seemed to stand alone without being
based on it. Buya Hamka's written interpretation is Tafsir Al
Azhar.
Keywords: Preaching, Sufism, Buya Hamka, Tafsir Al-Azhar. Abstrak Buya Hamka merupakan salah satu pendakwah dan sekaligus
mufassir yang menyebarkan dakwahnya lewat pengajaran
tasawuf modern, yang mana tasawuf modern ini merupakan
terobosan baru di antara tasawuf yang dikembangkan para sufi.
Buya Hamka juga memiliki sebuah karya fenomenal yaitu tafsir
Al-Azhar, yang terdapat juga pengajaran tasawuf modern
didalam tafsirnya. Jurnal ini bertujuan untuk mengetahui
penafsiran Hamka secara konseptualisasi yang bersinergi
dengan dakwah sufistik dalam penerapan dakwah Islam praktis.
Metode yang dipakai dalam penelitian ini adalah kualitatif
deskriptif dengan pendekatan analisis konten, yaitu penulis
berupaya untuk mengkaji dan menganalisa apakah ada
keterkitan antara ayat-ayat sufistik didalam tafsir Al-Azhar dan
ayat-ayat tasawuf yang beliau kutip dalam ceramahnya. Adapun
hasil temuan dari kajian ini adalah, bahwa dalam tafsir Al
Azhar Buya Hamka lebih banyak menjelaskan makna
isyarahnya, sedangkan tafsir oral Buya Hamka dala,
ceramahnya terlihat berbeda, hal ini terlihat dari ayat-ayat yang
ditafsirkan secara oral didalam ceramah tasawuf Buya Hamka,
beliau mengutip ayat Al-Quran dan menjelaskan makna dari
ayat tersebut sesuai dengan makna lahiriyahnya, yang mana
terlihat bahwa tafsir oral Buya Hamka dalam ceramahnya
terkesan berdiri sendiri tanpa mendasari dengan tafsir tulis Buya
Hamka yaitu Tafsir Al-Azhar.
Kata kunci: Dakwah, Sufistik, Buya Hamka, Tafsir Al-Azhar
Tradition and Islamic Learning Singapore Students in the Al-Azhar University
No full textThe Al-Azhar University remains the top destination for Southeast Asian students pursuing an Islamic studies degree. The university, built in the last millennium, has been able to withstand competition from modern universities across the globe and continues to produce influential Islamic studies graduates. What are the motivations of students pursuing a degree at Al-Azhar? What are the challenges they face? Are they certain of their future and career opportunities upon their return to Singapore? This book combines both qualitative and quantitative analysis of former and current students at the Al-Azhar University. It not only hopes to develop more critical analysis of returning Al-Azhar graduates but also attempts to understand the deeper connections between Muslims in Southeast Asia, particularly Singapore, and the Middle East.Intro -- Table of Contents -- 1. INTRODUCTION: Islamic Education and Religious Authority -- 2. THE AL-AZHAR UNIVERSITY: A Historical Sketch -- 3. PROMINENT SOUTHEAST ASIAN AL-AZHAR GRADUATES -- 4. AL-AZHAR TODAY: The Experience of Singapore Students -- 5. CONCLUSION -- BIBLIOGRAPHY -- INDEX -- ABOUT THE AUTHOR -- PHOTO PLATESThe Al-Azhar University remains the top destination for Southeast Asian students pursuing an Islamic studies degree. The university, built in the last millennium, has been able to withstand competition from modern universities across the globe and continues to produce influential Islamic studies graduates. What are the motivations of students pursuing a degree at Al-Azhar? What are the challenges they face? Are they certain of their future and career opportunities upon their return to Singapore? This book combines both qualitative and quantitative analysis of former and current students at the Al-Azhar University. It not only hopes to develop more critical analysis of returning Al-Azhar graduates but also attempts to understand the deeper connections between Muslims in Southeast Asia, particularly Singapore, and the Middle East.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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