1,721,095 research outputs found
3D Cell Printing of Implantable Vascularized Pancreatic Construct using iPSC-derived IPC for T1D
No full textIslet transplantation is a promising treatment of Type I diabetes (T1D), but it has several limitations. The viability and functionality of the transplanted islets are low because of the poor vascularity and hypoxic condition [1-2]. With the convergence of 3D bioprinting, bioink and human induced pluripotent stem cell (hiPSC), tissue engineering offers a promising alternative. In this study, we developed the 3D cell printed pancreatic construct for the alternative treatment of T1D.1
3D cell printing of implantable vascularized pancreatic construct using tissue-specific bioink and islet for T1D
No full textThe transplantation of pancreatic islets is promising treatment for patients of type 1 diabetes, suffering hypoglycaemia and secondary complications. The primary goal of this treatment is to supply sufficient amount of insulin in the bloodstream, however, several limitations still remain. In particular, 60% of the islet graft in the intrahepatic transplant site is difficult to survive due to low engraftment rate and hostile environment [1]. In case of subcutaneous transplantation, the viability and function of the implanted islet is diminished because of the low vascularity occurring hypoxic condition [2]. With the convergence of 3D bioprinting, bioink and stem cell biology approaches, tissue engineering offers a promising alternative. We developed the 3D cell printed pancreatic construct using pdECM and vascular cells that can provide beneficial microenvironmental cues. Thus, this construct can regulate blood glucose level in diabetic animal models and has shown a significant potential of the advanced islet delivery method for the treatment of type 1 diabetes.1
Development of implantable vascularized pancreatic construct by 3D cell printing technology
No full textThe transplantation of pancreatic islets is promising treatment for patients of type 1 diabetes, suffering hypoglycaemia and secondary complications. The primary goal of this treatment is to supply sufficient amount of insulin in the bloodstream, however, several limitations still remain. Large number of the islet graft in the intrahepatic transplant site is difficult to survive due to low engraftment rate and hostile environment. In case of subcutaneous transplantation, the viability and function of the implanted islet is diminished because of the low vascularity occurring hypoxic condition. With the convergence of 3D bioprinting, bioink and stem cell biology approaches, tissue engineering offers a promising alternative. Pancreatic islets were encapsulated in Pancreas tissue-derived extracellular matrix (pdECM) bioink in order to provide a physiologically relevant microenvironment, which could improve the viability and functionality of the cells. Also, insulin producing cells(IPCs) were differentiated from human pluripotent stem cells. Human umbilical vein endothelial cells (HUVECs) were co-cultured with the cells in the pancreatic construct in order to prevent hypoxia and provide a positive effect on the islets. We developed the 3D cell printed pancreatic construct using pdECM bioink, IPC and vascular cells that could potential be an advanced islet delivery method for the treatment of type 1 diabetes.2
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
3D Bioprinting of Macro Hepatic Tissue Module Using Light-Activated Liver Decellularized Extracellular Matrix-Based Bioink
No full text1
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Efficient Grid-based Electronic Structure Calculations
No full textDensity functional theory (DFT) is certainly the most popular method for electronic structure calculations, because it provides a cost-effective means of obtaining reliable results for various applications. Though DFT is formally exact, its numerical accuracy and efficiency is sensitive to the type of basis sets, since it determines the completeness of variational space and the numerical algorithm for solving Schrodinger equation, respectively. Recently, we developed a self-consistent field program based on DFT using Lagrange-sinc functions (LSFs) as a basis set. Though the Lagrange-sinc basis set is based numerical grids, it offers analytical evaluation for Laplacian and some local potential integrals, allowing for rapid and accurate calculations of Hartree terms and pseudopotential integrals. In addition, scalable-parallelization is possible up to thousands cores. Use of multi-grids effectively removes the so-called egg-box effect and greatly reduces computational costs thanks to large grid spacing. We have also extended our code to multiconfiguration methods with a reference configuration obtained from exact exchange Kohn-Sham orbitals, which allows more efficient calculations compared to standard post-Hartree-Fock approaches. In this talk, we present details of our method and numerical results for ground and excited state calculations.
[1] Sunghwan Choi, Kwangwoo Hong, Jaewook Kim, and Woo Youn Kim, Accuracy of Lagrange-sinc Functions as a Basis Set for Electronic Structure Calculations of Atoms and Molecules, J. Chem. Phys. 2015, 142, 094116.
[2] Jaewook Kim, Kwangwoo Hong, Sunghwan Choi, and Woo Youn Kim, Feature of Exact Exchange Kohn-Sham Orbitals with Krieger-Li-Iafrate Approximation, Bull. Korean Chem. Soc. 2015, 36, 998-1007.
[3] Jaewook Kim, Kwangwoo Hong, Sunghwan Choi, Sang-Yeon Hwang, and Woo Youn Kim, Configuration Interaction Singles based on Real-Space Numerical Grid Method: Kohn-Sham versus Hartree-Fock Orbitals, Phys. Chem. Chem. 2015, Phys. in revision
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