1,721,950 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Abstract 4718: Filamin A interacting protein 1-like is a marker of prognosis, progression and chemosensitivity in ovarian cancer
No full textAbstract
Purpose: The WNT/β-catenin pathway and the resulting epithelial-to-mesenchymal transition (EMT) play a key role in ovarian cancer progression and chemoresistance. Filamin A interacting protein 1-like (FILIP1L) enhances β-catenin degradation, thereby inhibiting canonical WNT signaling and EMT. FILIP1L is a tumor suppressor whose expression is down-regulated by promoter hyper-methylation in ovarian cancer. FILIP1L down-regulation is inversely correlated with the invasive potential of ovarian cancer cells. However, the clinical relevance of FILIP1L down-regulation in ovarian cancer progression has yet to be addressed.
Experimental design: To study the clinical implications of FILIP1L in regulating the WNT/β-catenin pathway and chemoresistance, the expression of FILIP1L, β-catenin, SNAIL and SLUG was analyzed by immunohistochemistry on tissue microarrays of 369 ovarian samples ranging from normal to metastatic. Their expression was evaluated with clinicopathological characteristics including FIGO stage and chemosensitivity, and correlated with overall and disease-free survival by Kaplan-Meier plots and Cox proportional hazards model.
Results: We demonstrated that FILIP1L expression decreased with tumor progression, resulting in a significant difference between primary and metastatic ovarian cancer samples. In contrast, levels of β-catenin and SLUG increased with tumor progression. Furthermore, tumors that were resistant to platinum/paclitaxel combination therapy showed a significant reduction in FILIP1L expression when compared to sensitive tumors, contrary to SLUG expression, which was significantly higher. The expression of FILIP1L was negatively correlated with the expression of β-catenin and SLUG, whereas β-catenin expression was positively correlated with SLUG expression, suggesting a link between FILIP1L and the WNT/β-catenin pathway in ovarian cancer. Moreover, patients with low FILIP1L expression showed a median overall survival and disease-free survival of 60 and 19 months, respectively, whereas patients with high FILIP1L expression had not yet reached median overall and disease-free survival at their 120 month follow-up. Notably, low FILIP1L expression was independent negative prognostic factor with respect to overall and disease-free survival.
Conclusions: Our study provides the first clinical relevance of FILIP1L in human cancer, and suggests that FILIP1L may be a novel biomarker for good prognosis and lower probability of recurrence in ovarian cancer patients.
Citation Format: Mijung Kwon, Jae-Hoon Kim, Chel Hun Choi, Joon-Yong Chung, Stephen Hewitt, Steven Libutti. Filamin A interacting protein 1-like is a marker of prognosis, progression and chemosensitivity in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4718. doi:10.1158/1538-7445.AM2017-4718</jats:p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
치과용 지르코니아 세라믹에 대한 접착
Full text link학위논문 (박사)-- 서울대학교 대학원 : 치의과학과, 2014. 8. 조병훈.Introduction
The first purpose of this study was to determine the bond strength of resin cement to zirconia ceramic after different surface treatments by means of three shear bond strength (SBS) test methods and to compare the sensitivity and the reliability of the SBS test methods. The second purpose was to evaluate the performance of the new universal adhesives (Single Bond Universal, 3M ESPE and All-Bond Universal, Bisco Inc.) as a surface treatment agent for zirconia with a test method established through the foregoing experiment.
Materials and methods
In Experiment I, polished zirconia ceramic (Cercon® base, DeguDent) slabs were randomly divided into four surface treatment groups: no treatment (C), airborne-particle abrasion (A), treatment with a conventional phosphate monomer-containing primer (Alloy Primer, Kuraray Co.) (P), and treatment with Alloy Primer after airborne-particle abrasion (AP). Bond strengths of resin cement to the zirconia specimens of each surface treatment group were determined by three SBS test methods: Method 1, the conventional SBS test with direct filling of the mold (Ø 4 mm x 3 mm) with resin cementMethod 2, the conventional SBS test with cementation of prefabricated composite cylinders (Ø 4 mm x 3 mm) using resin cementMethod 3, the microshear bond strength (μSBS) test with cementation of prefabricated composite cylinders (Ø 0.8 mm x 1 mm) using resin cement. The bond strength data were statistically analyzed using two-way analysis of variance (ANOVA) with factors of SBS test method and surface treatment. One-way ANOVA followed by Dunnett T3 test was performed to compare bond strengths. The coefficient of variation (CV) and the Weibull parameters were used to compare the consistency and reliability of the three test methods. In Experiment II, the performance of universal adhesives containing phosphate monomer as a surface treatment agent for zirconia was evaluated with a test method established through Experiment I and compared to that of Alloy Primer. A conventional single-bottle adhesive (Single Bond 2, 3M ESPE) was used as a negative control. Bond strengths were obtained after 24 h of water storage and after 10,000 thermocycles between 5°C and 55°C with a 25 s dwell time. The bond strength data were statistically analyzed using one-way ANOVA followed by Tukeys HSD test.
Results
Both SBS test method and surface treatment significantly influenced the SBS values (p < 0.05). The AP group showed the highest bond strength regardless of the test methods. Only Method 3 (μSBS test) revealed a significant difference between the P group and the A group, such that, as the SBS values increased, the CV decreased and the Weibull parameters increased. Method 3 was the most discriminative test method, producing consistent and reliable results. Method 3 was thus used to evaluate the effects of the universal adhesives on the bond strength of resin cement to zirconia. Single Bond Universal showed the highest initial bond strength (37.7 ± 5.1 MPa), followed by All-Bond Universal (31.3 ± 5.6 MPa), Alloy Primer (26.9 ± 5.1 MPa), and Single Bond 2 (8.5 ± 4.6 MPa). Artificial aging significantly reduced the bond strengths of all the test groups (p < 0.05). However, the bond strengths of Single Bond Universal (20.7 ± 6.4 MPa) and All-Bond Universal (26.9 ± 6.9 MPa) remained significantly higher than that of Alloy Primer (10.7 ± 4.2 MPa) after thermocycling (p < 0.05).
Conclusions
The μSBS test was more discriminative in differentiating the effects of surface treatments than the conventional SBS tests. The combination of airborne-particle abrasion and a primer containing phosphate monomer was the most effective in improving the bond strength of resin cement to zirconia. The universal adhesives significantly improved the bond strength and its durability of resin cement to zirconia when compared to Alloy Primer.Abstract
Introduction
Experiment I: Comparison of shear test methods to zirconia
Materials and methods
Results
Experiment II: Shear bond strength of multi-purpose, universal adhesives to zirconia
Materials and methods
Results
Discussion
Conclusions
References
Tables and Figures
국문초록Docto
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