243 research outputs found
Fluoxetine as disease modifying treatment in multiple sclerosis : rationale, evaluation of the use of MRI to monitor treatment, and preliminary findings
No full textPatients with multiple sclerosis (MS) lack astrocytic β2-adrenergic receptors and this may contribute to the focal inflammatory demyelinating lesions and axonal degeneration that characterize this disease. We hypothesized that the antidepressant fluoxetine might be able to compensate for the loss of the β2-adrenergic receptors. In this thesis we evaluated the use of cerebral MRI scans to monitor disease activity and we performed several exploratory studies to evaluate effects of fluoxetine on patients with MS.
A convenient way to find out whether a drug is able to reduce disease activity in MS is by measuring the development of new focal lesions on serial MRI scans of the brain.
MS patients who received fluoxetine during 6 months had a trend towards the development of less new focal lesions compared to patients receiving placebo. To assess whether preventing new lesions formation reduces disability on the long term, we studied the relationship between the focal (T2) lesions and disease progression. The number of focal lesions predicted progression of disability and conversion to a progressive disease course in patients with relapsing remitting MS. However, once patients had entered the progressive phase, T2 lesions were no longer predictive for further progression of disability. In another study, we found that 2 weeks use of fluoxetine resulted in an increase in NAA/Cr (a marker of axonal function) in the white matter of MS patients.
These preliminary studies suggest that fluoxetine reduces new focal lesion formation and may improve axonal metabolism in MS patients.
Geological Survey of Queensland and University of Queensland, School of Earth Sciences Theses Geochemistry and Geochronology Databases.
No full textThese databases contain: 1. Records of all theses submitted by Earth Sciences students over the past 70 years. 2. The Access Geochronology and Geochemistry database contains thesis title, author, date submitted, supervisor, and area studied; Sample numbers, specimen localities (map coordinates), rock type, unit, description, depth (if from borehole data), precision of locality and thesis reference; geochemical data (elemental or oxide abundances) and analytical limits (precision and detection limits for analytical method used), as well as the instrumentation used for each analysis (XRF, ICP-OES, ICP-MS etc); isotope geochemistry (with analytical limits indicated); and geochronological results (age, methodology, with analytical limits indicated). 3.Two Excel databases are also provided which, together, provide all the information available in the Access database. 4.This website also contains, in separate folders, ArcGIS and MapInfo files containing tables and maps displaying the locations of the study sites and the localities of individual samples taken for each thesis. Each icon represents a sample locality. Information embedded within each locality icon includes the author, title of the thesis, date, and various analytical results. 5. Please note: Browser windows in the MapInfo and ArcGIS files fill empty cells with zeros. This may give rise to the erroneous impression that certain elements may be present at very low concentrations while in fact there have been no analyses for those elements at all. Users are advised to check null values in the databases. 6. Recently, a new (limited) database containing mineral chemistry, with accompanying digital maps have also been included, with a similar structure as the geochemistry and geochronology databases
Présentation
No full textMoeschler Jacques. Présentation. In: Langages, 27ᵉ année, n°112, 1993. Temps, référence et inférence, sous la direction de Jacques Moeschler. pp. 5-7
The Netherlands
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Water Resource
Improved heat tolerance in air drives the recurrent evolution of air-breathing
No full textThe transition to air-breathing by formerly aquatic species has occurred repeatedly and independently in fish, crabs and other animal phyla, but the proximate drivers of this key innovation remain a long-standing puzzle in evolutionary biology. Most studies attribute the onset of air-breathing to the repeated occurrence of aquatic hypoxia; however, this hypothesis leaves the current geographical distribution of the 300 genera of air-breathing crabs unexplained. Here, we show that their occurrence is mainly related to high environmental temperatures in the tropics. We also demonstrate in an amphibious crab that the reduced cost of oxygen supply in air extends aerobic performance to higher temperatures and thus widens the animal's thermal niche. These findings suggest that high water temperature as a driver consistently explains the numerous times air-breathing has evolved. The data also indicate a central role for oxygenand capacity-limited thermal tolerance not only in shaping sensitivity to current climate change but also in underpinning the climate-dependent evolution of animals, in this case the evolution of air-breathing. © 2014 The Author(s) Published by the Royal Society. All rights reserved.link_to_subscribed_fulltex
Technique for human-error-sequence identification and signification
No full textMechanical Maritime and Materials Engineerin
De speelruimte voor het waterschapsbestuur
No full textIn de voorgaande hoofdstukken stond de vraag centraal hoeveel invloed de ingezetenen van een waterschap hebben op de besluitvorming door het waterschapsbestuur. In dit hoofdstuk staat de vraag centraal welke speelruimte de waterschapsbesturen hebben. Kunnen zij een eigen beleid voeren of zijn zij met hand en en voeten gebonden aan wet- en regelgeving en aan nationaal en provinciaal beleid? Om deze vraag te kunnen beantwoorden, zal aandacht besteed worden aan de wettelijke taken en doelstellingen van de waterschappen en hun juridische bevoegdheden. Verder zullen hun financiele middelen en hun relatie met andere partijen aan bod komen. De conclusie van dit hoofdstuk is dat wat betreft de speelruimte van het waterschapsbestuur het glas voor driekwart vol is.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Water Resource
Recommendations and guidelines on sustainable river basin management
No full textThis report contains the outcomes of the workshop: the "Recommendations andGuidelines on Sustainable River Basin Management" and a short key message.These outcomes were formulated by the participants in parallel and plenarysessions, and adopted in the final session. The annexes of this report contain thelist of participants and the workshop programme. Proceedings including allkeynote papers and several other contributions will be published separately.Water Resource
Colligere et compilare, voces paginarum. Organiser la parole de Dieu et la critique historique de la répétition écrite. Recherches sur l’origine de la tradition antijuive en Occident (1000-1322)
No full textComposition du jury : Jean-Claude Schmitt, directeur de thèse, ÉHESS ;Nicole Bériou, Université Lyon 2 ;Jacques Berlioz, CNRS ;Marco Mostert, Université d’Utrecht ;Michele Ferrari, Université d’Erlangen. Thèse soutenue le 17 avril 2015, mention très honorable Résumé : La thèse porte sur un problème de la critique philologique et historique moins étudiée, c’est-à-dire celui de la répétition de textes sans variantes importantes, dont les leçons sont presque toujours retenues par les philologues..
Between arguments, interests and expertise: the institutional development of the Dutch water boards, 1953-present
No full textThe Dutch water boards perform essential tasks for the Netherlands and generally effectively, yet they have often been called old-fashioned, ineffective and expensive. This paper describes and analyses the discussions on the water boards since 1953 in order to increase insight in the factors that influence institutional change in water management. In this period the water boards have changed a lot: their number has been reduced from 2670 to 24, they got new tasks, and more groups are now represented and contribute financially. But they have also successfully resisted proposals to abolish them or cancel the reserved seats for specific groups. Change occurred when groups with a vested interest in the water boards, such as agriculture, saw the change as strengthening the boards, and when these groups were relatively weak and could be overruled. In other cases there was continuity. One of the factors influencing the strength of these groups was their influence on public discourse via, for instance, the many advisory bodies with water board experts on them.Water Resource
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