1,984 research outputs found
sj-docx-1-jad-10.1177_10870547231204010 – Supplemental material for Association of Time in Bed, Social Jetlag, and Sleep Disturbances With Cognitive Performance in Children With ADHD
No full textSupplemental material, sj-docx-1-jad-10.1177_10870547231204010 for Association of Time in Bed, Social Jetlag, and Sleep Disturbances With Cognitive Performance in Children With ADHD by Xueqi Qu, Luther G. Kalb, Calliope Holingue, Darlynn M. Rojo-Wissar, Alison E. Pritchard, Adam P. Spira, Heather E. Volk and Lisa A. Jacobson in Journal of Attention Disorders</p
Level of curation self-reported by 100 CoreTrustSeal certified repositories (2017-2019)
No full textThis dataset extracts and makes machine-actionable the responses to the "Level of curation performed" component of the CoreTrustSeal application v01 (2017-2019). The author reviewed 100 applications in pdf file format and compiled the responses into one spreadsheet for further analysis. Additionally, the CTS application instructions for v01 were parsed in order to analyze the completed applications and included here in a spreadsheet.Alfred P Sloan FoundationJohnston, Lisa R. (2021). Level of curation self-reported by 100 CoreTrustSeal certified repositories (2017-2019). Retrieved from the University Digital Conservancy, https://doi.org/10.13020/w0z3-z709
Interviews: Dr. Lisa Meloncon, RHM Editor, interviews Dr. Abby Dubisar and Sara Davis on their persuasion brief, “Communicating Elective Sterilization: A Feminist Perspective”
No full textDownload of the interview includes 1) transcript and 2) Appendices A, B, and C from Dr. Abby Dubisar and Sara DavisThis interview is published as Meloncon, Lisa; Trauth, Erin; and Molloy, Cathryn (2019) "RHM Author Interview: Dr. Lisa Meloncon, RHM Editor, interviews Dr. Abby Dubisar and Sara Davis on their persuasion brief, “Communicating Elective Sterilization: A Feminist Perspective”, Rhetoric of Health & Medicine: 2019, 2(1). Posted with permission. </p
Obtaining Thickness-Limited Electrospray Deposition for 3D coating
No full textThe electrospray process utilizes the balance of electrostatic forces and surface tension within a charged spray to produce charged microdroplets with a narrow dispersion in size. In electrospray deposition, each droplet carries a small quantity of suspended material to a target substrate. Past electrospray deposition results fall into two major categories: (1) continuous spray of films onto conducting substrates and (2) spray of isolated droplets onto insulating substrates. A cross-over regime, or a self-limited spray, has only been limitedly observed in the spray of insulating materials onto conductive substrates. In such sprays, a limiting thickness emerges where the accumulation of charge repels further spray. In this study, we examined the parametric spray of several glassy polymers to both categorize past electrospray deposition results and uncover the critical parameters for thickness-limited sprays. The key parameters for determining the limiting thickness were (1) field strength and (2) the spray temperature, related to (1) the necessary repulsive field and (2) the ability for the deposited materials to swell in the carrier solvent vapor and redistribute charge. These control mechanisms can be applied to the uniform or controllably varied microscale coating of complex 3D objects.Peer reviewe
Spacecraft and interplanetary contributions to the magnetic environment on-board LISA pathfinder
No full textThis is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review. The version of record Armano, Michele, et al. "Spacecraft and interplanetary contributions to the magnetic environment on-board LISA Pathfinder." Monthly Notices of the Royal Astronomical Society 494.2 (2020): 3014-3027. is available online at: https://academic.oup.com/mnras/article-abstract/494/2/3014/5822062?redirectedFrom=fulltextLISA Pathfinder (LPF) has been a space-based mission designed to test new technologies that will be required for a gravitational wave observatory in space. Magnetically driven forces play a key role in the instrument sensitivity in the low-frequency regime (mHz and below), the measurement band of interest for a space-based observatory. The magnetic field can couple to the magnetic susceptibility and remanent magnetic moment from the test masses and disturb them from their geodesic movement. LPF carried on-board a dedicated magnetic measurement subsystem with noise levels of 10 nT Hz-1/2 from 1 Hz down to 1 mHz. In this paper we report on the magnetic measurements throughout LPF operations. We characterize the magnetic environment within the spacecraft, study the time evolution of the magnetic field and its stability down to 20 µHz, where we measure values around 200 nT Hz-1/2¿, and identify two different frequency regimes, one related to the interplanetary magnetic field and the other to the magnetic field originating inside the spacecraft. Finally, we characterize the non-stationary component of the fluctuations of the magnetic field below the mHz and relate them to the dynamics of the solar wind.This work has been made possible by the LISA Pathfindermission, which is part of the space-science program ofthe European Space Agency. The French contribution hasbeen supported by CNES (Accord Specific de projet CNES1316634/CNRS 103747), the CNRS, the Observatoire deParis and the University Paris-Diderot. E. P. and H. I. wouldalso like to acknowledge the financial support of the Uni-vEarthS Labex program at Sorbonne Paris CiteÌ↪A (ANR-10-LABX-0023 and ANR-11- IDEX-0005-02). The Albert-Einstein-Institut acknowledges the support of the GermanSpace Agency, DLR. The work is supported by the Fed-eral Ministry for Economic Affairs and Energy based on aresolution of the German Bundestag (FKZ 50OQ0501 andFKZ 50OQ1601). The Italian contribution has been sup-ported by Agenzia Spaziale Italiana and Instituto Nazionaledi Fisica Nucleare. The Spanish contribution has been sup-ported by Contracts No. AYA2010-15709 (MICINN), No.ESP2013-47637-P, and No. ESP2015-67234-P (MINECO).M. N. acknowledges support from Fundación General CSIC(Programa ComFuturo). F. R. acknowledges support froma Formación de Personal Investigador (MINECO) contract.The Swiss contribution acknowledges the support of theSwiss Space Office (SSO) via the PRODEX Programme ofESA. L. F. acknowledges the support of the Swiss NationalScience Foundation. The UK groups wish to acknowledgesupport from the United Kingdom Space Agency (UKSA),the University of Glasgow, the University of Birmingham,Imperial College, and the Scottish Universities Physics Al-liance (SUPA). J.I.T. and J.S. acknowledge the support ofthe U.S. National Aeronautics and Space Administration(NASA).Peer ReviewedPostprint (author's final draft
Social networks: the future of marketing for small business
No full textPurpose – The authors review recent developments in online marketing strategy that demonstrate the growing power of online communities in building brand reputations and customer relationships. Design/methodologies/approach – This work draws upon the results of an ongoing research project that is investigating the use of new technologies by entrepreneurial growing businesses in the London area. A range of examples from our 30 case study businesses are drawn upon to illustrate some of the opportunities and threats associated with these new marketing priorities.<br/
TRENDS, PREDICTORS AND OUTCOMES ASSOCIATED WITH UNSTRUCTURED TREATMENT INTERRUPTIONS AMONG HIV-POSITIVE INDIVIDUALS ON ANTIRETROVIRAL THERAPY IN CANADA
No full textBackground
The expanded use of combination antiretroviral therapy (cART) has dramatically enhanced the quality of care and life expectancy of HIV-positive individuals. However, incomplete adherence and treatment interruptions (TIs) due to treatment fatigue, side effects and cART toxicities have emerged as major challenges to the full realization of the therapeutic promise of cART. Despite the relatively high frequency of TIs, their determinants and outcomes are still not well-characterized.
Methods
Trends, predictors and consequences of treatment interruption (TI) and resumption in two study populations were estimated. First, the Longitudinal Investigations into Supportive and Ancillary health services (LISA) is a cross-sectional study of hard-to-reach individuals on cART in British Columbia. Between 2007 and 2010, 1000 participants were interviewed about sociodemographic and clinical factors. Using pharmacy recording, TIs were defined as a patient-initiated interruption in treatment of at least 90 days during the 12 months preceding or following the study interview. Multivariable logistic regression was used to identify factors associated with treatment interruption. The second study, the Canadian Observational Cohort (CANOC) collaboration, is composed of treatment-naïve HIV-positive individuals who initiated cART between 2000-2011. TIs were defined as interruptions in cART for a period of at least 90 days. Cox proportional hazards regression was used to identify determinants and consequences of cART interruption and resumption.
Results
Of 768 participants included in the LISA study, 15% had a TI recorded during the study window. In multivariable analysis, TIs were significantly associated with current illicit drug use (adjusted odds ratio (aOR): 1.68, 95% confidence interval [CI]: 1.05-2.68); <95% adherence in the first year of treatment (aOR: 2.68, 95% CI: 1.67-4.12); living with more than one person (aOR: 1.95; 95% CI: 1.22-3.14) or on the street (aOR: 5.08, 95% CI: 1.72-14.99) compared to living alone; poor perception of overall health (aOR: 1.64 95% CI: 1.05-2.55); being unemployed (aOR: 2.22, 95% CI: 1.16-4.23); and younger age at interview (aOR: 0.57, 95% CI: 0.44-0.75, per 10 year increment).
A total of 7,633 CANOC participants initiating cART between 2000 and 2011, of whom 1,860 (24.5%) had at least one TI ≥90 days. The prevalence of TI in the first calendar year of cART decreased by half over the study period. Predictors of a first TI were female sex (adjusted hazard ratio (aHR): 1.59, 95% CI: 1.33-1.92), Aboriginal ancestry (aHR: 1.67, 1.27-2.20), a history of injecting drug use (aHR: 1.43, CI: 1.09-1.89), hepatitis C antibody seropositivity (aHR: 2.17, CI: 1.68-2.79), a baseline CD4 cell count above 350 cells/mm3 versus less than 200 cells/mm3 (aHR: 1.46, CI: 1.17-1.81) and use of zidovudine versus tenofovir in the initial cART regimen (aHR: 2.47, CI: 1.92-3.20). Factors protective against TI were older age (aHR: 0.79, CI: 0.73-0.87), higher HIV plasma viral load (log10) (aHR: 0.87, CI: 0.78-0.97) and residence in Ontario (aHR: 0.55, CI: 0.43-0.70) or Quebec (aHR: 0.42, CI: 0.31-0.57) versus British Columbia (BC). Factors predicting resumption of treatment after a first TI included male sex, residence in BC, older age, more recent cART initiation and a CD4 cell count <200 cells/mm3 at cART initiation (all p<0.05). TIs were associated with increased risk of mortality (aHR: 1.79, CI: (1.49-2.16)) after adjusting for socio-demographic and clinical factors.
Conclusions
Despite significant improvements in cART since its advent and the decreasing prevalence of TIs, gaps in treatment remain relatively common. As cART is propagated at increasing levels globally, and the impetus to provide treatment earlier in the course of HIV infection for individual and public health benefits gains momentum, ensuring continuity of treatment becomes even more vital. Strategies to support continuous HIV treatment are needed to maximize the benefits of cART
Examining Surgical Outcomes for Thoracic Cancers within a Clinical Setting: A Clinical Epidemiologic Perspective
No full textAbstract
Background: Lung and esophageal cancer rank among cancers associated with the highest mortality both in the United States and the World. Surgical intervention provides the best opportunity for cure for these cancers.
Objectives: The objective was to identify factors associated with outcomes in surgical patients with thoracic cancers within a single hospital setting. We sought to achieve this goal with three aims, 1) examine the association between adjuvant chemotherapy and mortality among esophageal adenocarcinoma patients who received combined neoadjuvant chemoradiation therapy followed by surgery, 2) investigate differences by race on recommendation for surgery and survival among early stage non-small cell lung cancer (NSCLC) patients, and 3) determine the effect of HIV infection on post-surgical outcomes among NSCLC patients.
Methods: Data from the Johns Hopkins Hospital Cancer Registry were used for the retrospective cohort study designs and analyses. The Kaplan-Meier method was used to illustrate time to postoperative events. To estimate associations with postoperative mortality we applied Cox proportional hazards regression models. Poisson regression with robust variance was used to estimate the prevalence ratio of surgical recommendation.
Results: Aim 1: There was a long-term survival benefit following surgery for patients who received adjuvant chemotherapy compared to no adjuvant chemotherapy (median survival in months: 37.9 vs. 24.7; p=0.057, respectively). Receipt of adjuvant chemotherapy was associated with a 25% decrease in the aHR for postoperative mortality compared to patients who did not receive adjuvant chemotherapy (0.75; 95% CI 0.55-1.01).
Aim 2: Black patients were 8% less likely to be recommended surgical resection as compared to white patients (crude RR=0.92, 95% CI 0.86-0.98), but this association became null after controlling for patient-, tumor-, and physician-related factors (aRR=0.99, 95% CI 0.93-1.05). There was no significant association between race and mortality (aHR=1.17, 95% CI 0.89-1.55).
Aim 3: The median survival time for HIV-infected cancer patients was significantly shorter than for HIV-unspecified patients (26 vs. 48 months; p=0.001). Mortality among HIV-infected patients was more than threefold that of HIV-unspecified patients (aHR=3.08; 95% CI 1.85-5.13). When additional surgical characteristics were modeled in a matched sub-cohort, the association remained statistically significant (aHR=2.31; 95% CI 1.11-4.81).
Conclusions: Adjuvant chemotherapy for patients with locally advanced esophageal adenocarcinoma was associated with reduced postoperative mortality compared to no adjuvant chemotherapy. Race was not independently associated with surgical recommendation or mortality for early stage NSCLC. After surgery, HIV-infected NSCLC patients have poorer survival than HIV-unspecified NSCLC patients.
Thesis Advisor:
Elizabeth A. Platz, ScD, MPH, Department of Epidemiology
Thesis Readers:
Norma Kanarek, PhD, MPH, Department of Environmental Health Sciences (chair)
Lisa P. Jacobson, ScD, MS, Department of Epidemiology
Malcolm V. Brock, MD, Departments of Surgery and Oncology
Elizabeth Sugar, PhD, Department of Biostatistics
Gregory D. Kirk, MD, PhD, MPH, Department of Epidemiolog
Lisa-S 2.8g autopilot for GPS-based flight of MAVs
No full textRecent advances in sensor miniaturization have enabled the development of a miniaturized fully functional autopilot. In this article, the open hardware and open software Paparazzi-UAV Lisa-S micro autopilot is presented, weighing only 2.8 grams and measuring 2 by 2 centimeters. It incorporates 2-way telemetry with a ground station, a Spektrum DMS2/DSMX remote control, an IMU (Inertial Measurement Unit), a Magnetometer, a GPS module and a 32-bit 72 MHz processor for stabilization and navigation. As an illustration, the Lisa-S has been mounted on various miniature multi-rotors. Mounting it on a Ladybird quadrotor leads to a 8.5 by 8.5 cm system weighing 27 grams (excluding battery). Flight results are shown of the Ladybird performing autonomous GPS-based navigation missions outdoors.Control & OperationsAerospace Engineerin
PENERAPAN KESELAMATAN DAN KESEHATAN KERJA (K3) PADA KITCHEN DEPARTMENT DI HOTEL LA LISA SURABAYA
No full textThe Final Project is being prepared with the goal of determining the
application of occupational safety and health in the kitchen department of Hotel
La Lisa Surabaya. The author observes the application of occupational safety and
health in the kitchen department of the La Lisa Hotel Surabaya. The kitchen
environment (kitchen environment) includes ventilation or fans, lighting or lights,
walls or walls, ceiling or air exhaust, doors and windows, drains (plumbing) and
drainage, and toilets. Then there's personal protective equipment (PPE), light fire
extinguishers (APAR), and evacuation routes. Based on the discussion that the
author has described, it can be concluded that the application of occupational
safety and health in the kitchen department at the La Lisa Hotel has been properly
implemented, including the use of Personal Protective Equipment by the kitchen
crew at the La Lisa Hotel, the presence of one fire extinguisher in the kitchen area,
and the existence of an evacuation route that allows all employees and hotel
guests to easily exit the building
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