101,914 research outputs found
JACOBSON RADICAL ALGEBRAS WITH QUADRATIC GROWTH
No full textWe show that over every countable algebraically closed field K there exists a finitely generated K-algebra that is Jacobson radical, infinite-dimensional, generated by two elements, graded and has quadratic growth. We also propose a way of constructing examples of algebras with quadratic growth that satisfy special types of relations.</p
Jacobson, G A, 22102
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/394773Surname: JACOBSON. Given Name(s) or Initials: G A. Military Service Number or Last Known Location: 22102. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 53954.227900
Item: [2016.0049.27066] "Jacobson, G A, 22102
Proper Ferroelectricity in the Dion?Jacobson Material CsBi2Ti2NbO10: Experiment and Theory
Get PDFA diverse range of materials and properties are exhibited by layered perovskites. We report on the synthesis, characterization, and computational investigation of a new ferroelectric?CsBi2Ti2NbO10, an n = 3 member of the Dion?Jacobson (DJ) family. Structural studies using variable temperature neutron powder diffraction indicate that a combination of octahedral rotations and polar displacements result in the polar structure. Density functional theory calculations reveal that the wider perovskite blocks in CsBi2Ti2NbO0 stabilize proper ferroelectricity, in contrast to the hybrid-improper ferroelectricity reported for all other DJ phases. Our results raise the possibility of a new class of proper ferroelectric materials analogous to the well-known Aurivillius phases
Al Jacobson and Paul Johnson : the history of JSJ Corporation
No full textAl Jacobson and Paul Johnson trace the emergence of JSJ Corporation in Grand Haven. Paul, along with Al's father, was one of the founders of the company, which was organized in 1970. Paul and Al share stories about their childhood in Muskegon and Grand Haven. They give a detailed description of the Michigan Brass Company and Grand Haven Stamped Products and the formation of JSJ (Johnson, Sherwood, and Jacobson) Corporation. The two also share stories about boating on Spring Lake and the Spring Lake Yacht Club
Recent development on computer aided engineering of GPCR ligands: the human A3 adenosine receptors as an example.
No full textG-protein-coupled receptors (GPCRs) represent the largest known family of signal-transducing molecules, and convey signals for light and many extracellular regulatory molecules. GPCRs are dysfunctional or dysregulated in several human diseases and are estimated to be the targets of >40% of the drugs used in clinical medicine today. The crystal structure of rhodopsin provides the first information on the three-dimensional structure of GPCRs, which now supports homology modeling studies and structure-based drug-design approaches. In this article, we review recent work on adenosine receptors, a family of GPCRs, and, in particular, on adenosine A(3) receptor antagonists. We focus on an iterative, bi-directional approach in which models are used to generate hypotheses that are tested by experimentation; the experimental findings are, in turn, used to refine the model. The success of this approach is due to the synergistic interaction between theory and experimentation
Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding
No full textAdenosine is an endogenous modulator exerting its functions through the activation of four adenosine receptor (AR) subtypes, termed A1, A2A, A2B and A3, which belong to the G protein-coupled receptor (GPCR) superfamily. The human A3AR (hA3AR) subtype is implicated in several cytoprotective functions. Therefore, hA3AR modulators, and in particular agonists, are sought for their potential application as anti-inflammatory, anticancer, and cardioprotective agents. Structure-based molecular modeling techniques have been applied over the years to rationalize the structure–activity relationships (SARs) of newly emerged A3AR ligands, guide the subsequent lead optimization, and interpret site-directed mutagenesis (SDM) data from a molecular perspective. In this review, we showcase selected modeling-based and guided strategies that were applied to elucidate the binding of agonists to the A3AR and discuss the challenges associated with an accurate prediction of the receptor extracellular vestibule through homology modeling from the available X-ray templates
Progress in the pursuit of therapeutic adenosine receptor antagonists
Get PDFEver since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine receptors continue to represent promising drug targets. First, this is due to the fact that the receptors are expressed in a large variety of tissues. In particular, the actions of adenosine (or methylxanthine antagonists) in the central nervous system, in the circulation, on immune cells, and on other tissues can be beneficial in certain disorders. Second, there exists a large number of ligands, which have been generated by introducing several modifications in the structure of the lead compounds (adenosine and methylxanthine), some of them highly specific. Four adenosine receptor subtypes (A1, A2A, A2B, and A3) have been cloned and pharmacologically characterized, all of which are G protein-coupled receptors. Adenosine receptors can be distinguished according to their preferred mechanism of signal transduction: A1 and A3 receptors interact with pertussis toxin-sensitive G proteins of the Gi and Go family; the canonical signaling mechanism of the A2A and of the A2B receptors is stimulation of adenylyl cyclase via Gs proteins. In addition to the coupling to adenylyl cyclase, all four subtypes may positively couple to phospholipase C via different G protein subunits. The development of new ligands, in particular, potent and selective antagonists, for all subtypes of adenosine receptors has so far been directed by traditional medicinal chemistry. The availability of genetic information promises to facilitate understanding of the drug-receptor interaction leading to the rational design of a potentially therapeutically important class of drugs. Moreover, molecular modeling may further rationalize observed interactions between the receptors and their ligands. In this review, we will summarize the most relevant progress in developing new therapeutic adenosine receptor antagonists
On the Jacobson radical of strongly group graded rings
Get PDFsummary:For any non-torsion group with identity , we construct a strongly -graded ring such that the Jacobson radical is locally nilpotent, but is not locally nilpotent. This answers a question posed by Puczy{\l}owski
P2Y14 Receptor
No full textHistorical Background
Extracellular purine and pyrimidine nucleotides act as signaling molecules through the activation of P2X ion channels and P2Y G protein-coupled receptors (GPCRs) (Abbracchio et al. 2006). Among the eight members of the P2Y receptor family, four respond to extracellular uracil nucleotides: P2Y2, P2Y4, P2Y6, and P2Y14 receptors. None of the P2X ion channels are substantially activated by uracil nucleotides.
P2Y2, P2Y4, and P2Y6 receptors belong to the P2Y1-like subgroup of Gq-coupled receptors, and the P2Y14 receptor belongs to the P2Y12-like subgroup that couples to G protein αi to inhibit adenylyl cyclase. The P2Y14 receptor is distributed in various tissues, that is, placenta, adipose, stomach, intestine, spleen, thymus, lung, heart, mast cells, and discrete brain regions (Freeman et al. 2001; Harden et al. 2010). It is activated by uridine-5′-diphosphoglucose (UDPG, 1, Fig. 1), other endogenous UDP-sugars, and uridine-5′-diphosphate..
Transient evoked otoacoustic emission-basedscreening in typical nurseries: A response to Jacobson and Jacobson
No full textJacobson and Jacobson (Int. J. Pediatr. Otorhinolaryngol. 29 (1994) 235-248) recently questioned whether TEOAE-based newborn hearing screening similar to what was recommended by the National Institutes of Health could be implemented in a typical nursery setting. They concluded that, \u27the theoretical advantage of TEOAEs as a method for screening newborn babies at risk for hearing loss may not be realized in acute practice.\u27 This article presents data based on dozens of currently operational TEOAE-based newborn hearing screening programs which demonstrate that the concerns raised by Jacobson and Jacobson are not representative of what is being experienced by operational newborn hearing screening programs
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