393 research outputs found
In the Midst of Change, a Few Truths Remain—A Review of Trazenfeld and Jarvis’s Florida Legal Malpractice Law
Get PDFAbstract forthcoming
Negative Commentary—Negative Consequences: Legal Ethics, Social Media, and the Impact of Explosive Commentary
Get PDFConnecting and sharing on social media has opened communication channels and provided instantaneous information to billions of people worldwide. Commentary on current events, cases, and negative online reviews may be posted in an instant, often without pause or thought about the potential repercussions. This global phenomenon may not only provide news of the day updates, humor, and support for those in need but also is replete with ethical landmines for the unwary lawyer. Lawyers commenting on current events, their cases, or responding to a client’s negative online review, have suffered damage to their careers. In some instances, they have even faced disciplinary consequences for their online conduct. This Article not only recounts some of these unfortunate events but also attempts to provide insight into how both communication strategies and self-awareness techniques may be used to build a preventative toolbox for a lawyer’s social media engagement
Amino acid profiling from fingerprints, a novel methodology using UPLC-MS
No full textFingermark evidence is extensively used in criminal investigations. Hence, there have been many investigations into the chemical compounds present in fingerprint deposits. In this technical note we describe the analysis of non-derivatised amino acid profiles obtained from fingerprints. We used UPLC with an amide stationary phase and subsequent detection using a triple quadrupole MS/MS and TOF-MS detector. The linearity (R2) was satisfactory for both MS detectors (>0.98 for all amino acids in the case of the triple quadrupole MS/MS and >0.96 in the case of the TOF-MS). Although the triple quadrupole had a higher sensitivity for most amino acids, both mass spectrometers were able to retrieve the amino acid profiles of fingerprints from 19 donors. Between these profiles, only minor differences were observed between the separate analyses on the different mass analyzers, mainly in l-proline, l-lysine and l-phenylalanine abundances. Surprisingly, the mean RSD in amino acid profiles from duplicate fingerprints turned out to be lower for the TOF-MS (18.6% ± 6.6% vs. 13.2% ± 3.8%), as did the mean RSD of the intraday reproducibility (8.22% ± 1.94% vs. 9.54% ± 3.07%).OLD ChemE/Organic Materials and Interface
Gronow, Jan: transcript of an audio interview (23-Oct-2015)
Get PDFInterview with Professor Jan Gronow, conducted by Ms Lynda Finn, for the History of Modern Biomedicine Research Group, 23 October 2015, in Imperial College London. Transcribed by Mrs Debra Gee, and edited by Ms Emma M. Jones and Professor Tilli Tansey. The editorial assistance, the project management and the technical support were undertaken by Ms Fiona Plowman, Mr Adam Wilkinson and Mr Alan Yabsley, respectively. Professor Jan Gronow PhD BA FMinSoc MCIWEM (b. 1945) was Visiting Professor in Waste Policy at the Centre for Environmental Policy at Imperial College London from 2005. She is a geochemist and joined the Department of the Environment’s Waste Technical Division in 1988 and then joined the Environment Agency on its formation in 1996. She managed the Government’s waste research programme over a period of 17 years and provided technical advice on waste and resource management to policy colleagues in Defra and its predecessors and in the Environment Agency over that time. She was a member of the UK team that negotiated waste-related legislation in Europe for 15 years. She chaired the EU Technical Advisory Committee that developed the Landfill Directive waste acceptance criteria between 2001 and 2002. Jan has been an independent consultant since 2005. She was a strategic advisor to Defra’s Waste Evidence Team from 2006 to 2012. She was co-author of Defra’s Waste and Resources Evidence Strategy, 2007-2011, drafted to assist with the implementation of the Waste Strategy for England, 2007. She has been a Member of the Engineering and Physical Sciences Research Council (EPSRC) Peer Review College since 2006.The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity (no. 210183). The current interview has been funded by the Wellcome Trust Strategic Award entitled “Makers of modern biomedicine: testimonies and legacy” (2012-2017; awarded to Professor Tilli Tansey)
Efficacy of alemtuzumab over 6 years in relapsing–remitting multiple sclerosis patients who relapsed between courses 1 and 2: Post hoc analysis of the CARE-MS studies
No full textBackground:Alemtuzumab is administered as two annual courses for relapsing-remitting multiple sclerosis (MS). Patients may relapse before completing the two-course regimen. Objective: The objective was to evaluate 6-year outcomes in patients who relapsed between alemtuzumab Courses 1 and 2 (early relapsers). Methods:Post hoc analysis of patients from the Comparison of Alemtuzumab and Rebif (R) Efficacy in Multiple Sclerosis (CARE-MS) studies who enrolled in the extension. Results:Early relapsers (CARE-MS I: 15%; CARE-MS II: 24%) had more relapses in 1-2 years pre-alemtuzumab and higher mean baseline Expanded Disability Status Scale score than patients without relapse. Their annualized relapse rate declined from Year 1 (CARE-MS I: 1.3; CARE-MS II: 1.2) to Year 2 following Course 2 (0.3; 0.5) and remained low thereafter. Over 6 years, 60% remained free of 6-month confirmed disability worsening; 24% (CARE-MS I) and 34% (CARE-MS II) achieved 6-month confirmed disability improvement. During Year 6, 69% (CARE-MS I) and 68% (CARE-MS II) were free of magnetic resonance imaging (MRI) disease activity. Median percent yearly brain volume loss (Year 1: -0.67% (CARE-MS I); -0.47% (CARE-MS II)) declined after Course 2 (Year 6: -0.24%; -0.13%). Conclusion: Early relapsers' outcomes improved after completing the second alemtuzumab course. These findings support administering the approved two-course regimen to maximize clinical benefit. ClinicalTrials.gov registration numbers:CARE-MS I, II, extension: NCT00530348, NCT00548405, NCT00930553.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The CARE-MS I, CARE-MS II, and CAMMS03409 studies were funded by Sanofi and Bayer HealthCare Pharmaceuticals. Only Sanofi contributed to the conduct of the studies; collection, management, analysis, and interpretation of the data; review of the manuscript. Apart from the Sanofi employees listed as authors, the funders had no role in preparation, approval, and decision to submit the manuscript for publication.Van Wijmeersch, B (reprint author), Hasselt Univ, Fac Med & Life Sci, Campus Hasselt,Martelarenlaan 42, B-3500 Hasselt, Belgium.
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Fluoxetine as disease modifying treatment in multiple sclerosis : rationale, evaluation of the use of MRI to monitor treatment, and preliminary findings
Get PDFPatients with multiple sclerosis (MS) lack astrocytic β2-adrenergic receptors and this may contribute to the focal inflammatory demyelinating lesions and axonal degeneration that characterize this disease. We hypothesized that the antidepressant fluoxetine might be able to compensate for the loss of the β2-adrenergic receptors. In this thesis we evaluated the use of cerebral MRI scans to monitor disease activity and we performed several exploratory studies to evaluate effects of fluoxetine on patients with MS.
A convenient way to find out whether a drug is able to reduce disease activity in MS is by measuring the development of new focal lesions on serial MRI scans of the brain.
MS patients who received fluoxetine during 6 months had a trend towards the development of less new focal lesions compared to patients receiving placebo. To assess whether preventing new lesions formation reduces disability on the long term, we studied the relationship between the focal (T2) lesions and disease progression. The number of focal lesions predicted progression of disability and conversion to a progressive disease course in patients with relapsing remitting MS. However, once patients had entered the progressive phase, T2 lesions were no longer predictive for further progression of disability. In another study, we found that 2 weeks use of fluoxetine resulted in an increase in NAA/Cr (a marker of axonal function) in the white matter of MS patients.
These preliminary studies suggest that fluoxetine reduces new focal lesion formation and may improve axonal metabolism in MS patients.
Sewing the Body of Christ : Eucharist wafer souvenirs stitched into fifteenth-century manuscripts, primarily in the Netherlands
No full textBooks of hours in the fifteenth century occupied several social and devotional roles. People used them to store small objects, including metal badges. Although the cultural practice of sewing in badges was widespread in the late Middle Ages, nearly all of the badges were removed (by later collectors). This article examines the practice by considering needle holes and offsets in the soft parchment, which indicate the shape of the badges and where they were attached. Noting that vast majority of metal offsets in books of hours are round, the author posits that these were not impressed by pilgrims’ badges, as is often repeated in the scholarly literature, but rather by tokens that commemorate having taken the Eucharist. The round badges are the same size and shape and bear the same imagery as host wafers. Owners stitched such badges into their books’ margins at locations relevant to Eucharistic piety. When they were sewn into books, Eucharist badges reconfigured the book as a shrine that recorded a votary’s pursuit of Communion.Peer reviewe
Bernadine Dunfee
No full textBERNADINE L. DUNFEE
NBS: 1943-1976
Birth: May 13, 1914, Coal Grove, Ohio
Death: October 14, 2009
Education:
Wilmington College (Ohio), BS (education), 1939
George Washington University, MS (physics), 1955
Principal Field:
Voltage and Current Ratio Standards
Positions Held at NBS:
Project Leader, Electricity Division
Chief, Electrical Instruments Section, Electricity Division
NBS Museum Committee (w/ Francis Silsbee)
Honors:
U. S. Department of Commerce Silver Medal, 1969
NBS Nominee for Federal Women’s Award, 1968
Institute of Electrical and Electronics Engineers (IEEE): IEEE Prize Paper, 1960
Sigma Pi Sigma
Sigma Xi
Memberships:
Institute of Electrical and Electronics Engineers, Senior Member, Fellow
American National Standards Institute (ANSI)
Standards Alumni Association, Director, 1988-1994
Publications:
Numerous papers related to electrical standards and measurements, including:
Methods for Measuring the “Q” of Large Reactors (coauthor),Trans. AIEE Winter Meeting, (Jan-Feb 1956)
An A-C Kelvin Bridge for the Audio-Frequency Range, AIEE Trans., (May 1956)
A Standard Current Transformer and Comparison Method... , IRE Trans. Instr., (1960)
Method for Calibrating a Standard Volt Box, NBS J. Res. 67, (Jan-Mar 1963)
The Design and Performance of Multi-Range Current Transformer Standards for Audio Frequencies, IEEE Trans. IM-14, 4, (Dec. 1965)
An International Comparison of Current Ratios at Audio Frequencies (co-author), IEEE Trans. IM-14, 4, (Dec. 1965)
Electrical Standards and Measurements (co-author), ElectroTechnology, 79, (Jan. 1967)
Resistive Voltage Ratio Standard and Measuring Circuit (co-author), IEEE Trans. IM-19, (Nov. 1970
Redistribution of garbage codes to underlying causes of death: a systematic analysis on Italy and a comparison with most populous Western European countries based on the Global Burden of Disease Study 2019 (Jan, 10.1093/eurpub/ckab194, 2022)
No full textIn the originally published version of this manuscript, an author was erroneously omitted from the list of authors. The list should read:
“Lorenzo Monasta, Gianfranco Alicandro, Maja Pasovic, Matthew Cunningham, Benedetta Armocida, Christopher J L Murray, Luca
Ronfani, Mohsen Naghavi, GBD 2019 Italy Causes of Death Collaborators” instead of “Lorenzo Monasta, Gianfranco Alicandro, Maja
Pasovic, Matthew Cunningham, Benedetta Armocida, Luca Ronfani, Mohsen Naghavi, GBD 2019 Italy Causes of Death Collaborators”. This
error has been corrected online
Free Town Libraries, their Formation, Management, and History ; in Britain, France, Germany and America. ; Together with brief Notices of Book-collectors, and of the respective Places of Deposit of their surviving Collections
Get PDF« Document numérisé pour l\u27ENSSIB » - L\u27auteur de ce document, Edward Edwards, fut l\u27un des instigateurs et défenseurs des " Free Town Libraries " (bibliothèques municipales publiques) en Grande-Bretagne au milieu du XIXe siècle. Son ouvrage s\u27inscrit dans un contexte historique important pour le pays, faisant suite aux " Libraries Acts " de 1850, instaurant les bibliothèques publiques dans les villes anglaises. Edwards fut d\u27ailleurs le premier bibliothécaire de la bibliothèque publique de Manchester. L\u27objectif de son livre est de servir de manuel quant à l\u27organisation de ce type de bibliothèque et de promouvoir celui-ci plus largement. Dans un second temps, il vise à comparer les différents systèmes mis en place dans quelques pays étrangers, spécialement la France, l\u27Allemagne et les États-Unis. Composé de quatre livres, l\u27ouvrage offre une étude comparative des diverses expériences menées et s\u27appuie sur les textes législatifs, notamment en ce qui concerne la Grande-Bretagne. Cette oeuvre est fondamentale pour l\u27historien s\u27intéressant au développement des bibliothèques publiques au XIXe siècle. Elle est complétée par de précieuses notices sur les grands collectionneurs européens et américains (qui forment le quatrième livre)
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